Search Results - "Laranjeira, A B A"

DNA damage, demethylation and anticancer activity of DNA methyltransferase (DNMT) inhibitors by Laranjeira, Angelo B. A., Hollingshead, Melinda G., Nguyen, Dat, Kinders, Robert J., Doroshow, James H., Yang, Sherry X.

“…Role of DNA damage and demethylation on anticancer activity of DNA methyltransferase inhibitors (DNMTi) remains undefined. We report the effects of DNMT1 gene…”
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IL-7 Contributes to the Progression of Human T-cell Acute Lymphoblastic Leukemias by SILVA, Ana, LARANJEIRA, Angelo B. A, MARTINS, Leila R, CARDOSO, Bruno A, DEMENGEOT, Jocelyne, ANDRES YUNES, J, SEDDON, Benedict, BARATA, Joao T

“…The importance of microenvironmental factors for driving progression in leukemia has been debated. Previous evidence has pointed to interleukin-7 (IL-7), a…”
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Upregulation of TET2 and Resistance to DNA Methyltransferase (DNMT) Inhibitors in DNMT1 -Deleted Cancer Cells by Laranjeira, Angelo B A, Nguyen, Dat, Pelosof, Lorraine C, Doroshow, James H, Yang, Sherry X

“…Ten-eleven-translocation (TET) 2 is a member of the TET family of proteins (TET1-3). gene deletion confers resistance to DNA methyltransferase (DNMT)…”
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IGFBP7 participates in the reciprocal interaction between acute lymphoblastic leukemia and BM stromal cells and in leukemia resistance to asparaginase by Laranjeira, A B A, de Vasconcellos, J F, Sodek, L, Spago, M C, Fornazim, M C, Tone, L G, Brandalise, S R, Nowill, A E, Yunes, J A

“…The interaction of acute lymphoblastic leukemia (ALL) blasts with bone marrow (BM) stromal cells (BMSCs) has a positive impact on ALL resistance to…”
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Chimerism interpretation with a highly sensitive quantitative PCR method: 6 months median latency before chimerism drop below 0.1 by Vicente, D C, Laranjeira, A B A, Miranda, E C M, Yunes, J A, de Souza, C A

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TAL1 SCL is downregulated upon histone deacetylase inhibition in T-cell acute lymphoblastic leukemia cells by Cardoso, B A, de Almeida, S F, Laranjeira, A B A, Carmo-Fonseca, M, Yunes, J A, Coffer, P J, Barata, J T

“…The transcription factor T-cell acute lymphocytic leukemia (TAL)-1 is a major T-cell oncogene associated with poor prognosis in T-cell acute lymphoblastic…”
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Simultaneous detection of lysine metabolites by a single LC–MS/MS method: monitoring lysine degradation in mouse plasma by Pena, Izabella A., Marques, Lygia A., Laranjeira, Angelo B. A., Yunes, José A., Eberlin, Marcos N., Arruda, Paulo

“…Detection and quantification of lysine degradation metabolites in plasma is necessary for the diagnosis and follow-up of diseases such as pyridoxine-dependent…”
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Low-dose methotrexate in sickle-cell disease: a pilot study with rationale borrowed from rheumatoid arthritis by Brandalise, Silvia R, Assis, Rosemary, Laranjeira, Angelo B A, Yunes, José Andrés, de Campos-Lima, Pedro O

“…Inflammation is a major feature of sickle cell disease (SCD). Low-dose methotrexate (MTX) has long been used in chronic inflammatory diseases. This pilot study…”
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In vivo ablation of NF-κB cascade effectors alleviates disease burden in myeloproliferative neoplasms by Laranjeira, Angelo B. A., Kong, Tim, Snyder, Steven C., Fulbright, Mary C., Fisher, Daniel A. C., Starczynowski, Daniel T., Oh, Stephen T.

“…•Abrogation of RelA, Myd88, and IRAK4 consistently suppressed disease hallmarks of leukocytosis, splenomegaly, and bone marrow dysfunction.•IRAK4 inhibitor…”
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Comprehensive profiling of clinical JAK inhibitors in myeloproliferative neoplasms by Kong, Tim, Yu, LaYow, Laranjeira, Angelo B. A., Fisher, Daniel A. C., He, Fan, Cox, Maggie J., Oh, Stephen T.

“…Small molecule inhibitors targeting JAK2 provide symptomatic benefits for myeloproliferative neoplasm (MPN) patients and are among first‐line therapeutic…”
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Complementary and countervailing actions of Jak2 and Ikk2 in hematopoiesis in mice by Fisher, Daniel A.C., Laranjeira, Angelo B.A., Kong, Tim, Snyder, Steven C., Shim, Kevin, Fulbright, Mary C., Oh, Stephen T.

“…•Jak2 V617F and Ikk2-CA showed distinct and partly opposed effects on hematopoiesis.•Jak2 V617F and Ikk2-CA both antagonized frequency of transplantable…”
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Multiomic profiling reveals metabolic alterations mediating aberrant platelet activity and inflammation in myeloproliferative neoplasms by He, Fan, Laranjeira, Angelo Ba, Kong, Tim, Lin, Shuyang, Ashworth, Katrina J, Liu, Alice, Lasky, Nina M, Fisher, Daniel Ac, Cox, Maggie J, Fulbright, Mary C, Antunes-Heck, Lilian, Yu, LaYow, Brakhane, Molly, Gao, Bei, Sykes, Stephen M, D'Alessandro, Angelo, Di Paola, Jorge, Oh, Stephen T

“…Platelets from patients with myeloproliferative neoplasms (MPNs) exhibit a hyperreactive phenotype. Here, we found elevated P-selectin exposure and…”
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Mouse lysine catabolism to aminoadipate occurs primarily through the saccharopine pathway; implications for pyridoxine dependent epilepsy (PDE) by Pena, Izabella Agostinho, Marques, Lygia Azevedo, Laranjeira, Ângelo B.A., Yunes, José A., Eberlin, Marcos N., MacKenzie, Alex, Arruda, Paulo

“…Lysine is catabolized in mammals through the saccharopine and pipecolate pathways — the former is mainly hepatic and renal, and the latter is believed to play…”
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DUSP6 mediates resistance to JAK2 inhibition and drives leukemic progression by Kong, Tim, Laranjeira, Angelo B A, Yang, Kangning, Fisher, Daniel A C, Yu, LaYow, Poittevin De La Frégonnière, Laure, Wang, Anthony Z, Ruzinova, Marianna B, Fowles, Jared S, Fulbright, Mary C, Cox, Maggie J, Celik, Hamza, Challen, Grant A, Huang, Sidong, Oh, Stephen T

“…Myeloproliferative neoplasms (MPNs) exhibit a propensity for transformation to secondary acute myeloid leukemia (sAML), for which the underlying mechanisms…”
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Therapeutic target discovery and drug development in cancer stem cells for leukemia and lymphoma: from bench to the clinic by Laranjeira, Angelo B A, Yang, Sherry X

“…Cancer stem cells (CSCs), also known as tumor initialing cells, have self-renewal capacity and are believed to play an important role in residual disease or…”
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N-(1′-naphthyl)-3,4,5-trimethoxybenzohydrazide as microtubule destabilizer: Synthesis, cytotoxicity, inhibition of cell migration and in vivo activity against acute lymphoblastic leukemia by Salum, Lívia B., Mascarello, Alessandra, Canevarolo, Rafael R., Altei, Wanessa F., Laranjeira, Angelo B.A., Neuenfeldt, Patrícia D., Stumpf, Taisa R., Chiaradia-Delatorre, Louise D., Vollmer, Laura L., Daghestani, Hikmat N., de Souza Melo, Carolina P., Silveira, André B., Leal, Paulo C., Frederico, Marisa J.S., do Nascimento, Leandro F., Santos, Adair R.S., Andricopulo, Adriano D., Day, Billy W., Yunes, Rosendo A., Vogt, Andreas, Yunes, José A., Nunes, Ricardo J.

“…Tubulin-interacting agents, like vinca alkaloid and taxanes, play a fundamental role in cancer chemotherapy, making cellular microtubules (MT), one of the few…”
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Assessment of BCL2/J(H) translocation in healthy individuals exposed to low-level radiation of 137CsCl in Goiânia, Goiás, Brazil by Nunes, H F, Laranjeira, A B A, Yunes, J A, Costa, E O A, de A Melo, C O, de M e Silva, D, da Cruz, A D

“…Healthy radio-exposed individuals who received low levels of Cesium-137 radiation during the accident that occurred in Goiânia in 1987, their families and…”
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In Vivo Ablation of NFκB Cascade Effectors Alleviates Disease Burden in Myeloproliferative Neoplasms by Laranjeira, Angelo B. A., Kong, Tim, Snyder, Steven Craig, Fulbright, Mary C., Fisher, Daniel A.C., Starczynowski, Daniel T., Oh, Stephen T.

“…ABAL and TK equal contributors Multilevel regulation of NFκB activation exists in response to microenvironmental cues. Aberrant hyperactivation of the NFκB…”
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Galectin-1 Fuels Monocyte-Driven Hyperinflammation and Represents a Novel Therapeutic Target in Myeloproliferative Neoplasms by He, Fan, Kong, Tim, Lin, Shuyang, Fulbright, Mary C., Laranjeira, Angelo B. A., Fisher, Daniel A.C., Cox, Maggie J, Ashworth, Katrina, Di Paola, Jorge, Oh, Stephen T.

“…JDP and STO co-corresponding authors Previous studies by our group and others have demonstrated that monocytes play a key role in driving hyperinflammation in…”
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Aberrant Activity of the Calcium Sensor STIM1 Underlies Congenital Platelet Disorders and Myeloproliferative Neoplasms by Brakhane, Molly, Abbonante, Vittorio, Laranjeira, Angelo B. A., Di Buduo, Christian, Sadler, Brooke, Ashworth, Katrina, Kong, Tim, He, Fan, Fulbright, Mary C., Chen, Dong, Clemens, Regina, Pegoraro, Elena, Lambert, Michele P., Gollomp, Kandace, Di Paola, Jorge, Balduini, Alessandra, Oh, Stephen T.

“…MB and VA equal contributors AB and STO co-corresponding authors This study was initiated following evaluation of a 32 year-old woman who presented with a…”
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