Search Results - "Laprairie, Robert"

Crystal Structure of the Human Cannabinoid Receptor CB1 by Hua, Tian, Vemuri, Kiran, Pu, Mengchen, Qu, Lu, Han, Gye Won, Wu, Yiran, Zhao, Suwen, Shui, Wenqing, Li, Shanshan, Korde, Anisha, Laprairie, Robert B., Stahl, Edward L., Ho, Jo-Hao, Zvonok, Nikolai, Zhou, Han, Kufareva, Irina, Wu, Beili, Zhao, Qiang, Hanson, Michael A., Bohn, Laura M., Makriyannis, Alexandros, Stevens, Raymond C., Liu, Zhi-Jie

“…Cannabinoid receptor 1 (CB1) is the principal target of Δ9-tetrahydrocannabinol (THC), a psychoactive chemical from Cannabis sativa with a wide range of…”
Get full text

In vitro and in vivo pharmacological activity of minor cannabinoids isolated from Cannabis sativa by Zagzoog, Ayat, Mohamed, Kawthar A., Kim, Hye Ji J., Kim, Eunhyun D., Frank, Connor S., Black, Tallan, Jadhav, Pramodkumar D., Holbrook, Larry A., Laprairie, Robert B.

“…The Cannabis sativa plant contains more than 120 cannabinoids. With the exceptions of ∆ 9 -tetrahydrocannabinol (∆ 9 -THC) and cannabidiol (CBD), comparatively…”
Get full text

Allosteric and orthosteric pharmacology of cannabidiol and cannabidiol‐dimethylheptyl at the type 1 and type 2 cannabinoid receptors by Tham, Mylyne, Yilmaz, Orhan, Alaverdashvili, Mariam, Kelly, Melanie E M, Denovan‐Wright, Eileen M, Laprairie, Robert B

“…Background and Purpose We sought to understand why (−)‐cannabidiol (CBD) and (−)‐cannabidiol‐dimethylheptyl (CBD‐DMH) exhibit distinct pharmacology, despite…”
Get full text

Crystal structures of agonist-bound human cannabinoid receptor CB1 by Hua, Tian, Vemuri, Kiran, Nikas, Spyros P., Laprairie, Robert B., Wu, Yiran, Qu, Lu, Pu, Mengchen, Korde, Anisha, Jiang, Shan, Ho, Jo-Hao, Han, Gye Won, Ding, Kang, Li, Xuanxuan, Liu, Haiguang, Hanson, Michael A., Zhao, Suwen, Bohn, Laura M., Makriyannis, Alexandros, Stevens, Raymond C., Liu, Zhi-Jie

“…Crystal structures of the human cannabinoid receptor 1 (CB 1 ) bound to the agonists AM11542 and AM841 reveal notable structural rearrangements upon receptor…”
Get full text

Crystal structures of agonist-bound human cannabinoid receptor CB 1 by Hua, Tian, Vemuri, Kiran, Nikas, Spyros P, Laprairie, Robert B, Wu, Yiran, Qu, Lu, Pu, Mengchen, Korde, Anisha, Jiang, Shan, Ho, Jo-Hao, Han, Gye Won, Ding, Kang, Li, Xuanxuan, Liu, Haiguang, Hanson, Michael A, Zhao, Suwen, Bohn, Laura M, Makriyannis, Alexandros, Stevens, Raymond C, Liu, Zhi-Jie

“…The cannabinoid receptor 1 (CB ) is the principal target of the psychoactive constituent of marijuana, the partial agonist Δ -tetrahydrocannabinol (Δ -THC)…”
Get full text

Cannabinoids as an Emerging Therapy for Posttraumatic Stress Disorder and Substance Use Disorders by Cohen, Jacob, Wei, Zelan, Phang, Jonathan, Laprairie, Robert B., Zhang, Yanbo

“…Posttraumatic Stress Disorder (PTSD) is a leading psychiatric disorder that mainly affects military and veteran populations but can occur in anyone affected by…”
Get full text

The future of type 1 cannabinoid receptor allosteric ligands by Alaverdashvili, Mariam, Laprairie, Robert B.

“…Allosteric modulation of the type 1 cannabinoid receptor (CB1R) holds great therapeutic potential. This is because allosteric modulators do not possess…”
Get full text

Assessment of select synthetic cannabinoid receptor agonist bias and selectivity between the type 1 and type 2 cannabinoid receptor by Zagzoog, Ayat, Brandt, Asher L., Black, Tallan, Kim, Eunhyun D., Burkart, Riley, Patel, Mikin, Jin, Zhiyun, Nikolaeva, Maria, Laprairie, Robert B.

“…The first synthetic cannabinoid receptor agonists (SCRAs) were designed as tool compounds to study the endocannabinoid system’s two predominant cannabinoid…”
Get full text

Therapeutic potential of gamma entrainment using sensory stimulation for cognitive symptoms associated with schizophrenia by Black, Tallan, Jenkins, Bryan W., Laprairie, Robert B., Howland, John G.

“…Schizophrenia is a complex neuropsychiatric disorder with significant morbidity. Treatment options that address the spectrum of symptoms are limited,…”
Get full text

Estradiol-dependent hypocretinergic/orexinergic behaviors throughout the estrous cycle by Kim, Hye Ji J., Dickie, Samuel A., Laprairie, Robert B.

“…Rationale The female menstrual or estrous cycle and its associated fluctuations in circulating estradiol (E2), progesterone, and other gonadal hormones alter…”
Get full text

Cannabinoid receptor ligand bias: implications in the central nervous system by Laprairie, Robert B, Bagher, Amina M, Denovan-Wright, Eileen M

“…Highlights • Cannabinoid receptors are pleiotropically-coupled GPCRs. • Few studies quantify cannabinoid bias using Black and Leff's operational model. •…”
Get full text

Biased Type 1 Cannabinoid Receptor Signaling Influences Neuronal Viability in a Cell Culture Model of Huntington Disease by Laprairie, Robert B, Bagher, Amina M, Kelly, Melanie E M, Denovan-Wright, Eileen M

“…Huntington disease (HD) is an inherited, autosomal dominant, neurodegenerative disorder with limited treatment options. Prior to motor symptom onset or…”
Get more information

Addressing a major interference in the quantification of psilocin in mouse plasma: Development of a validated liquid chromatography tandem mass spectrometry method by Khajavinia, Amir, Michel, Deborah, Ezeaka, Udoka C., Purves, Randy W., Laprairie, Robert B., El-Aneed, Anas

“…•New LC-MS/MS validated quantification method of psilocin in plasma is developed.•Tryptophan interference prevented the use of reversed phase…”
Get full text

New Insights into Bitopic Orthosteric/Allosteric Ligands of Cannabinoid Receptor Type 2 by Ferrisi, Rebecca, Polini, Beatrice, Ricardi, Caterina, Gado, Francesca, Mohamed, Kawthar A, Baron, Giovanna, Faiella, Salvatore, Poli, Giulio, Rapposelli, Simona, Saccomanni, Giuseppe, Aldini, Giancarlo, Chiellini, Grazia, Laprairie, Robert B, Manera, Clementina, Ortore, Gabriella

“…Very recently, we have developed a new generation of ligands targeting the cannabinoid receptor type 2 (CB2R), namely compounds, which combine the…”
Get full text

Type 1 Cannabinoid Receptor Ligands Display Functional Selectivity in a Cell Culture Model of Striatal Medium Spiny Projection Neurons by Laprairie, Robert B., Bagher, Amina M., Kelly, Melanie E.M., Dupré, Denis J., Denovan-Wright, Eileen M.

“…Modulation of type 1 cannabinoid receptor (CB1) activity has been touted as a potential means of treating addiction, anxiety, depression, and…”
Get full text

Modulation of type 1 cannabinoid receptor activity by cannabinoid by-products from Cannabis sativa and non-cannabis phytomolecules by Zagzoog, Ayat, Cabecinha, Ashley, Abramovici, Hanan, Laprairie, Robert B.

“…Cannabis sativa contains more than 120 cannabinoids and 400 terpene compounds (i.e., phytomolecules) present in varying amounts. Cannabis is increasingly…”
Get full text

Comparing CB1 receptor GIRK channel responses to receptor internalization using a kinetic imaging assay by Andersen, Haley K., Vardakas, Duncan G., Lamothe, Julie A., Perault, Tannis E. A., Walsh, Kenneth B., Laprairie, Robert B.

“…The type 1 cannabinoid receptor (CB1R) mediates neurotransmitter release and synaptic plasticity in the central nervous system. Endogenous, plant-derived,…”
Get full text

Antipsychotic potential of the type 1 cannabinoid receptor positive allosteric modulator GAT211: preclinical in vitro and in vivo studies by McElroy, Dan L., Roebuck, Andrew J., Scott, Gavin A., Greba, Quentin, Garai, Sumanta, Denovan-Wright, Eileen M., Thakur, Ganesh A., Laprairie, Robert B., Howland, John G.

“…Rationale Antipsychotics help alleviate the positive symptoms associated with schizophrenia; however, their debilitating side effects have spurred the search…”
Get full text

Dissociable changes in spike and wave discharges following exposure to injected cannabinoids and smoked cannabis in Genetic Absence Epilepsy Rats from Strasbourg by Roebuck, Andrew J., Greba, Quentin, Onofrychuk, Timothy J., McElroy, Dan L., Sandini, Thaísa M., Zagzoog, Ayat, Simone, Jonathan, Cain, Stuart M., Snutch, Terrance P., Laprairie, Robert B., Howland, John G.

“…There is significant interest in the use of cannabinoids for the treatment of many epilepsies including absence epilepsy (AE). Genetic Absence Epilepsy Rats…”
Get full text

Positive allosteric modulation of type 1 cannabinoid receptors reduces spike-and-wave discharges in Genetic Absence Epilepsy Rats from Strasbourg by Roebuck, Andrew J., Greba, Quentin, Smolyakova, Anna-Maria, Alaverdashvili, Mariam, Marks, Wendie N., Garai, Sumanta, Baglot, Samantha L., Petrie, Gavin, Cain, Stuart M., Snutch, Terrance P., Thakur, Ganesh A., Hill, Matthew N., Howland, John G., Laprairie, Robert B.

“…Childhood Absence Epilepsy (CAE) accounts for approximately 10% of all pediatric epilepsies. Current treatments for CAE are ineffective in approximately 1/3 of…”
Get full text