Search Results - "Lappin, Sarah C."

Characterization of SB-705498, a potent and selective vanilloid receptor-1 (VR1/TRPV1) antagonist that inhibits the capsaicin-, acid-, and heat-mediated activation of the receptor by Gunthorpe, Martin J, Hannan, Sara Luis, Smart, Darren, Jerman, Jeffrey C, Arpino, Sandra, Smith, Graham D, Brough, Stephen, Wright, Jim, Egerton, Julie, Lappin, Sarah C, Holland, Vicky A, Winborn, Kim, Thompson, Mervyn, Rami, Harshad K, Randall, Andrew, Davis, John B

“…Vanilloid receptor-1 (TRPV1) is a nonselective cation channel, predominantly expressed by sensory neurons, which plays a key role in the detection of noxious…”
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TRPV1 antagonist, SB-366791, inhibits glutamatergic synaptic transmission in rat spinal dorsal horn following peripheral inflammation by Lappin, Sarah C., Randall, Andrew D., Gunthorpe, Martin J., Morisset, Valerie

“…The anti-hyperalgesic effects of TRPV1 receptor antagonists are well documented in animal models of pain, however, the precise site of their action is not…”
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Inhibition of Ih reduces epileptiform activity in rodent hippocampal slices by Gill, Catherine H., Brown, Jon T., Shivji, Nadia, Lappin, Sarah C., Farmer, Clare, Randall, Andrew, McNaughton, Nicolle C.L., Cobb, Stuart R., Davies, Ceri H.

“…Hyperpolarization‐activated cyclic nucleotide gated (HCN) ion channels regulate membrane potential, neurotransmitter release, and patterning of synchronized…”
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Design and synthesis of 6-phenylnicotinamide derivatives as antagonists of TRPV1 by Westaway, Susan M., Thompson, Mervyn, Rami, Harshad K., Stemp, Geoffrey, Trouw, Leontine S., Mitchell, Darren J., Seal, Jon T., Medhurst, Stephen J., Lappin, Sarah C., Biggs, James, Wright, James, Arpino, Sandra, Jerman, Jeffrey C., Cryan, Jennifer E., Holland, Vicky, Winborn, Kim Y., Coleman, Tanya, Stevens, Alexander J., Davis, John B., Gunthorpe, Martin J.

“…N-Quinolin-7-yl-6-phenylnicotinamide ( 2) was previously identified as a potent TRPV1 antagonist with activity in an in vivo model of inflammatory pain…”
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Activation of SK channels inhibits epileptiform bursting in hippocampal CA3 neurons by Lappin, Sarah C., Dale, Tim J., Brown, Jon T., Trezise, Derek J., Davies, Ceri H.

“…The role of calcium-activated potassium channels in the regulation of neuronal hyperexcitability, as in epilepsy, is unclear. To examine this issue, we have…”
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