Search Results - "Lappalainen, Anu"

Canine chondrodysplasia caused by a truncating mutation in collagen-binding integrin alpha subunit 10 by Kyöstilä, Kaisa, Lappalainen, Anu K, Lohi, Hannes

“…The skeletal dysplasias are disorders of the bone and cartilage tissues. Similarly to humans, several dog breeds have been reported to suffer from different…”
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Molecular Characterization of Three Canine Models of Human Rare Bone Diseases: Caffey, van den Ende-Gupta, and Raine Syndromes by Hytönen, Marjo K, Arumilli, Meharji, Lappalainen, Anu K, Owczarek-Lipska, Marta, Jagannathan, Vidhya, Hundi, Sruthi, Salmela, Elina, Venta, Patrick, Sarkiala, Eva, Jokinen, Tarja, Gorgas, Daniela, Kere, Juha, Nieminen, Pekka, Drögemüller, Cord, Lohi, Hannes

“…One to two percent of all children are born with a developmental disorder requiring pediatric hospital admissions. For many such syndromes, the molecular…”
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Polycythemia in dogs with chronic hypoxic pulmonary disease by Holopainen, Saila, Laurila, Henna P., Lappalainen, Anu K., Rajamäki, Minna M., Viitanen, Sanna J.

“…Background Prolonged tissue hypoxia caused by chronic pulmonary disease is commonly regarded as an important mechanism in the development of secondary…”
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Novel protective and risk loci in hip dysplasia in German Shepherds by Mikkola, Lea I, Holopainen, Saila, Lappalainen, Anu K, Pessa-Morikawa, Tiina, Augustine, Thomas J P, Arumilli, Meharji, Hytönen, Marjo K, Hakosalo, Osmo, Lohi, Hannes, Iivanainen, Antti

“…Canine hip dysplasia is a common, non-congenital, complex and hereditary disorder. It can inflict severe pain via secondary osteoarthritis and lead to…”
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Genetic dissection of canine hip dysplasia phenotypes and osteoarthritis reveals three novel loci by Mikkola, Lea, Holopainen, Saila, Pessa-Morikawa, Tiina, Lappalainen, Anu K, Hytönen, Marjo K, Lohi, Hannes, Iivanainen, Antti

“…Hip dysplasia and osteoarthritis continue to be prevalent problems in veterinary and human medicine. Canine hip dysplasia is particularly problematic as it…”
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Canine DVL2 variant contributes to brachycephalic phenotype and caudal vertebral anomalies by Niskanen, Julia E., Reunanen, Vilma, Salonen, Milla, Bannasch, Danika, Lappalainen, Anu K., Lohi, Hannes, Hytönen, Marjo K.

“…A frameshift deletion variant in the Wnt pathway gene dishevelled 2 ( DVL2 ) is associated with a truncated, kinked tail (“screw tail”) in English Bulldogs,…”
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A missense change in the ATG4D gene links aberrant autophagy to a neurodegenerative vacuolar storage disease by Kyöstilä, Kaisa, Syrjä, Pernilla, Jagannathan, Vidhya, Chandrasekar, Gayathri, Jokinen, Tarja S, Seppälä, Eija H, Becker, Doreen, Drögemüller, Michaela, Dietschi, Elisabeth, Drögemüller, Cord, Lang, Johann, Steffen, Frank, Rohdin, Cecilia, Jäderlund, Karin H, Lappalainen, Anu K, Hahn, Kerstin, Wohlsein, Peter, Baumgärtner, Wolfgang, Henke, Diana, Oevermann, Anna, Kere, Juha, Lohi, Hannes, Leeb, Tosso

“…Inherited neurodegenerative disorders are debilitating diseases that occur across different species. We have performed clinical, pathological and genetic…”
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An across-breed validation study of 46 genetic markers in canine hip dysplasia by Mikkola, Lea, Kyöstilä, Kaisa, Donner, Jonas, Lappalainen, Anu K, Hytönen, Marjo K, Lohi, Hannes, Iivanainen, Antti

“…Canine hip dysplasia (CHD) is a common disease, with a complex genetic background. Dogs with severe CHD sometimes also suffer from osteoarthritis (OA), an…”
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Polycythemia is uncommon in dogs with chronic hypoxic pulmonary disease by Holopainen, Saila, Laurila, Henna P, Lappalainen, Anu K, Rajamäki, Minna M, Viitanen, Sanna J

“…Prolonged tissue hypoxia caused by chronic pulmonary disease is commonly regarded as an important mechanism in the development of secondary polycythemia, but…”
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Comparison of submaximal exercise test results and severity of brachycephalic obstructive airway syndrome in English bulldogs by Lilja-Maula, Liisa, Lappalainen, Anu K., Hyytiäinen, Heli K., Kuusela, Erja, Kaimio, Mirja, Schildt, Kirsti, Mölsä, Sari, Morelius, Mikael, Rajamäki, Minna M.

“…•Exercise tests were used to assess brachycephalic obstructive airway syndrome (BOAS) in English bulldogs (EBs).•EBs with mild BOAS performed better in…”
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Persistent fontanelles in Chihuahuas. Part II: Association with craniocervical junction abnormalities, syringomyelia, and ventricular volume by Kiviranta, Anna‐Mariam, Rusbridge, Clare, Lappalainen, Anu K., Junnila, Jouni J. T., Jokinen, Tarja S.

“…Background Persistent fontanelles (PFs) are, in Chihuahuas, almost ubiquitous. Furthermore, Chihuahuas are predisposed to other craniomorphological…”
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Persistent fontanelles in Chihuahuas. Part I. Distribution and clinical relevance by Kiviranta, Anna‐Mariam, Rusbridge, Clare, Lappalainen, Anu K., Junnila, Jouni J. T., Jokinen, Tarja S.

“…Background The Chihuahua dog breed is known for frequent occurrence of a bregmatic fontanelle on the dorsal skull. A common conception is that this skull…”
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Intervertebral disc disease in Dachshunds radiographically screened for intervertebral disc calcifications by Lappalainen, Anu K, Vaittinen, Elina, Junnila, Jouni, Laitinen-Vapaavuori, Outi

“…BACKGROUND: Intervertebral disc disease (IDD) is a very common neurological disease, Dachshunds being the breed most often affected. In this breed, IDD has a…”
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Thoracic high resolution CT using the modified VetMousetrap™ device is a feasible method for diagnosing canine idiopathic pulmonary fibrosis in awake West Highland White Terriers by Holopainen, Saila, Rautala, Elina, Lilja‐Maula, Liisa, Lohi, Hannes, Rajamäki, Minna M., Lappalainen, Anu K.

“…Canine idiopathic pulmonary fibrosis is a chronic, progressive interstitial lung disease particularly prevalent in West Highland White Terriers. In the present…”
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Reliability of a New Bite Force Measure and Biomechanics of Modified Long Attack in Police Dogs by Hyytiäinen, Heli K, Blomvall, Laura, Hautala, Mikko, Lappalainen, Anu K

“…Information on the biomechanics of police dogs' tasks is important in understanding their work-related injuries and dysfunctions. This study aimed to develop…”
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A novel GUSB mutation in Brazilian terriers with severe skeletal abnormalities defines the disease as mucopolysaccharidosis VII by Hytönen, Marjo K, Arumilli, Meharji, Lappalainen, Anu K, Kallio, Heli, Snellman, Marjatta, Sainio, Kirsi, Lohi, Hannes

“…Hundreds of different human skeletal disorders have been characterized at molecular level and a growing number of resembling dysplasias with orthologous…”
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The Finnish Canine Stifle Index: responsiveness to change and intertester reliability by Hyytiäinen, Heli K, Morelius, Mikael, Lappalainen, Anu K, Bostrom, Anna F, Lind, Kirsti A, Junnila, Jouni J T, Hielm-Björkman, Anna, Laitinen-Vapaavuori, Outi

“…BackgroundThe responsiveness and the intertester reliability of the Finnish Canine Stifle Index (FCSI) were tested, and a cut-off between compromised and…”
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A homozygous missense variant in the alkaline phosphatase gene ALPL is associated with a severe form of canine hypophosphatasia by Kyöstilä, Kaisa, Syrjä, Pernilla, Lappalainen, Anu K., Arumilli, Meharji, Hundi, Sruthi, Karkamo, Veera, Viitmaa, Ranno, Hytönen, Marjo K., Lohi, Hannes

“…Inherited skeletal disorders affect both humans and animals. In the current study, we have performed series of clinical, pathological and genetic examinations…”
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Breed-typical front limb angular deformity is associated with clinical findings in three chondrodysplastic dog breeds by Lappalainen, Anu K, Pulkkinen, Hanna S M, Mölsä, Sari, Junnila, Jouni, Hyytiäinen, Heli K, Laitinen-Vapaavuori, Outi

“…Angular front limb deformity (ALD) refers to an excessively curved limb conformation, which is seen in some chondrodysplastic dog breeds. Common…”
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Aural CT characteristics of American Cocker Spaniels have features of both mesaticephalic and brachycephalic breeds by Kaimio, Mirja L. M., Lappalainen, Anu K., Rahmani, Vahideh, Männikkö, Sofia, Laitinen‐Vapaavuori, Outi M.

“…Otitis externa and otitis media are common in American Cocker Spaniels, however breed‐specific aural CT descriptions are currently lacking. This prospective…”
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