Search Results - "Lapish, Christopher C"

Distinct cortico-striatal compartments drive competition between adaptive and automatized behavior by Barnett, William H, Kuznetsov, Alexey, Lapish, Christopher C

“…Cortical and basal ganglia circuits play a crucial role in the formation of goal-directed and habitual behaviors. In this study, we investigate the…”
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Compulsive alcohol drinking in rodents is associated with altered representations of behavioral control and seeking in dorsal medial prefrontal cortex by Timme, Nicholas M., Ma, Baofeng, Linsenbardt, David, Cornwell, Ethan, Galbari, Taylor, Lapish, Christopher C.

“…A key feature of compulsive alcohol drinking is continuing to drink despite negative consequences. To examine the changes in neural activity that underlie this…”
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Rich-Club Organization in Effective Connectivity among Cortical Neurons by Nigam, Sunny, Shimono, Masanori, Ito, Shinya, Yeh, Fang-Chin, Timme, Nicholas, Myroshnychenko, Maxym, Lapish, Christopher C, Tosi, Zachary, Hottowy, Pawel, Smith, Wesley C, Masmanidis, Sotiris C, Litke, Alan M, Sporns, Olaf, Beggs, John M

“…The performance of complex networks, like the brain, depends on how effectively their elements communicate. Despite the importance of communication, it is…”
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Attracting dynamics of frontal cortex ensembles during memory-guided decision-making by Balaguer-Ballester, Emili, Lapish, Christopher C, Seamans, Jeremy K, Durstewitz, Daniel

“…A common theoretical view is that attractor-like properties of neuronal dynamics underlie cognitive processing. However, although often proposed theoretically,…”
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Comparing the prefrontal cortex of rats and primates: Insights from electrophysiology by Seamans, Jeremy K, Lapish, Christopher C., Durstewitz, Daniel

“…There is a long-standing debate about whether rats have what could be considered a prefrontal cortex (PFC) and, if they do, what its primate homologue is…”
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Dopamine Neurons Change the Type of Excitability in Response to Stimuli by Morozova, Ekaterina O, Zakharov, Denis, Gutkin, Boris S, Lapish, Christopher C, Kuznetsov, Alexey

“…The dynamics of neuronal excitability determine the neuron's response to stimuli, its synchronization and resonance properties and, ultimately, the…”
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Limbic and Motor Circuitry Underlying Footshock-Induced Reinstatement of Cocaine-Seeking Behavior by McFarland, Krista, Davidge, Susan B, Lapish, Christopher C, Kalivas, Peter W

“…The role of limbic, cortical, and striatal circuitry in a footshock reinstatement model of relapse to cocaine seeking was evaluated. Transient inhibition of…”
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Successful choice behavior is associated with distinct and coherent network states in anterior cingulate cortex by Lapish, Christopher C, Durstewitz, Daniel, Chandler, L. Judson, Seamans, Jeremy K

“…Successful decision making requires an ability to monitor contexts, actions, and outcomes. The anterior cingulate cortex (ACC) is thought to be critical for…”
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The ability of the mesocortical dopamine system to operate in distinct temporal modes by Lapish, Christopher C, Kroener, Sven, Durstewitz, Daniel, Lavin, Antonieta, Seamans, Jeremy K

“…This review discusses evidence that cells in the mesocortical dopamine (DA) system influence information processing in target areas across three distinct…”
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A Method to Present and Analyze Ensembles of Information Sources by Timme, Nicholas M., Linsenbardt, David, Lapish, Christopher C.

“…Information theory is a powerful tool for analyzing complex systems. In many areas of neuroscience, it is now possible to gather data from large ensembles of…”
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Mesocortical Dopamine Neurons Operate in Distinct Temporal Domains Using Multimodal Signaling by Lavin, Antonieta, Nogueira, Lourdes, Lapish, Christopher C, Wightman, R. Mark, Phillips, Paul E. M, Seamans, Jeremy K

“…In vivo extracellular recording studies have traditionally shown that dopamine (DA) transiently inhibits prefrontal cortex (PFC) neurons, yet recent…”
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Habitual Behavior Is Mediated by a Shift in Response-Outcome Encoding by Infralimbic Cortex by Barker, Jacqueline M, Glen, W Bailey, Linsenbardt, David N, Lapish, Christopher C, Chandler, L Judson

“…The ability to flexibly switch between goal-directed actions and habits is critical for adaptive behavior. The infralimbic prefrontal cortex (IfL-C) has been…”
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The rodent medial prefrontal cortex and associated circuits in orchestrating adaptive behavior under variable demands by Howland, John G., Ito, Rutsuko, Lapish, Christopher C., Villaruel, Franz R.

“…Emerging evidence implicates rodent medial prefrontal cortex (mPFC) in tasks requiring adaptation of behavior to changing information from external and…”
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A critical review of front‐loading: A maladaptive drinking pattern driven by alcohol's rewarding effects by Ardinger, Cherish E., Lapish, Christopher C., Czachowski, Cristine L., Grahame, Nicholas J.

“…Front‐loading is a drinking pattern in which alcohol intake is skewed toward the onset of reward access. This phenomenon has been reported across several…”
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Temporal Dynamics of Hippocampal and Medial Prefrontal Cortex Interactions During the Delay Period of a Working Memory-Guided Foraging Task by Myroshnychenko, Maxym, Seamans, Jeremy K, Phillips, Anthony G, Lapish, Christopher C

“…Connections between the hippocampus (HC) and medial prefrontal cortex (mPFC) are critical for working memory; however, the precise contribution of this pathway…”
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Ethanol Alters Variability, But Not Rate, of Firing in Medial Prefrontal Cortex Neurons of Awake‐Behaving Rats by Morningstar, Mitchell D., Linsenbardt, David N., Lapish, Christopher C.

“…Background The medial prefrontal cortex (mPFC) is a brain region involved in the evaluation and selection of motivationally relevant outcomes. Neural activity…”
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Effect of ketamine on binge drinking patterns in crossed high alcohol-preferring (cHAP) mice by Ardinger, Cherish E., Winkler, Garrett, Lapish, Christopher C., Grahame, Nicholas J.

“…Previous research has demonstrated the utility of subanesthetic doses of ketamine in decreasing binge (Drinking-in-the-Dark, or DID) 20% alcohol intake in…”
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Sex differences in neural networks recruited by frontloaded binge alcohol drinking by Ardinger, Cherish E., Chen, Yueyi, Kimbrough, Adam, Grahame, Nicholas J., Lapish, Christopher C.

“…Frontloading is an alcohol drinking pattern where intake is skewed towards the onset of access. This study aimed to identify brain regions involved in…”
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Non-consummatory behavior signals predict aversion-resistant alcohol drinking in head-fixed mice by Timme, Nicholas M, Ardinger, Cherish E, Weir, Seth D C, Zelaya-Escobar, Rachel, Kruger, Rachel, Lapish, Christopher C

“…A key facet of alcohol use disorder is continuing to drink alcohol despite negative consequences (so called "aversion-resistant drinking"). In this study, we…”
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Male and female impairments in odor span are observed in a rat model of PTSD by McGonigle, Colleen E, Lapish, Christopher C, Logrip, Marian L

“…Posttraumatic stress disorder (PTSD) is associated with neural and behavioral alterations in response to trauma exposure, including working memory impairments…”
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