Search Results - "Lapierre, Louis R."

Autophagy and Lipid Metabolism Coordinately Modulate Life Span in Germline-less C. elegans by Lapierre, Louis R., Gelino, Sara, Meléndez, Alicia, Hansen, Malene

“…The cellular recycling process of autophagy is emerging as a key player in several longevity pathways in Caenorhabditis elegans. Here, we identify a role for…”
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Transcriptional and epigenetic regulation of autophagy in aging by Lapierre, Louis R, Kumsta, Caroline, Sandri, Marco, Ballabio, Andrea, Hansen, Malene

“…Macroautophagy is a major intracellular degradation process recognized as playing a central role in cell survival and longevity. This multistep process is…”
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Selective Autophagy Receptor p62/SQSTM1, a Pivotal Player in Stress and Aging by Kumar, Anita V, Mills, Joslyn, Lapierre, Louis R

“…Efficient proteostasis is crucial for somatic maintenance, and its decline during aging leads to cellular dysfunction and disease. Selective autophagy is a…”
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Emerging topics in C. elegans aging research: Transcriptional regulation, stress response and epigenetics by Denzel, Martin S., Lapierre, Louis R., Mack, Hildegard I.D.

“…•Multiple transcription factors can modulate transcriptional signatures that improves somatic maintenance and longevity.•Neuroendocrine signals, reactive…”
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Visible light reduces C. elegans longevity by De Magalhaes Filho, C. Daniel, Henriquez, Brian, Seah, Nicole E., Evans, Ronald M., Lapierre, Louis R., Dillin, Andrew

“…The transparent nematode Caenorhabditis elegans can sense UV and blue-violet light to alter behavior. Because high-dose UV and blue-violet light are not a…”
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A pan-tissue DNA-methylation epigenetic clock based on deep learning by de Lima Camillo, Lucas Paulo, Lapierre, Louis R., Singh, Ritambhara

“…Several age predictors based on DNA methylation, dubbed epigenetic clocks, have been created in recent years, with the vast majority based on regularized…”
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Nuclear Export Inhibition Enhances HLH-30/TFEB Activity, Autophagy, and Lifespan by Silvestrini, Melissa J., Johnson, Joseph R., Kumar, Anita V., Thakurta, Tara G., Blais, Karine, Neill, Zachary A., Marion, Sarah W., St. Amand, Victoria, Reenan, Robert A., Lapierre, Louis R.

“…Transcriptional modulation of the process of autophagy involves the transcription factor HLH-30/TFEB. In order to systematically determine the regulatory…”
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Autophagy links lipid metabolism to longevity in C. elegans by Lapierre, Louis R., Meléndez, Alicia, Hansen, Malene

“…The cellular recycling process of autophagy is emerging as a central player in many of the conserved longevity pathways in C. elegans, but the underlying…”
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Reduced ech-6 expression attenuates fat-induced lifespan shortening in C. elegans by Liu, Yasmine J., Gao, Arwen W., Smith, Reuben L., Janssens, Georges E., Panneman, Daan M., Jongejan, Aldo, van Weeghel, Michel, Vaz, Frédéric M., Silvestrini, Melissa J., Lapierre, Louis R., MacInnes, Alyson W., Houtkooper, Riekelt H.

“…Deregulated energy homeostasis represents a hallmark of aging and results from complex gene-by-environment interactions. Here, we discovered that reducing the…”
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The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans by Lapierre, Louis R., De Magalhaes Filho, C. Daniel, McQuary, Philip R., Chu, Chu-Chiao, Visvikis, Orane, Chang, Jessica T., Gelino, Sara, Ong, Binnan, Davis, Andrew E., Irazoqui, Javier E., Dillin, Andrew, Hansen, Malene

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Autophagy in aging and longevity by Wong, Shi Q., Kumar, Anita V., Mills, Joslyn, Lapierre, Louis R.

“…Our understanding of the process of autophagy and its role in health and diseases has grown remarkably in the last two decades. Early work established…”
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Neuronal HLH-30/TFEB modulates thermoresistance and longevity in C. elegans by Lapierre, Louis R.

“…The conserved autophagy transcription factor HLH-30/TFEB is a well-established modulator of lifespan in several mechanistically-distinct longevity paradigms in…”
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Lipid droplets modulate proteostasis, SQST-1/SQSTM1 dynamics, and lifespan in C. elegans by Kumar, Anita V., Mills, Joslyn, Parker, Wesley M., Leitão, Joshua A., Rodriguez, Diego I., Daigle, Sandrine E., Ng, Celeste, Patel, Rishi, Aguilera, Joseph L., Johnson, Joseph R., Wong, Shi Quan, Lapierre, Louis R.

“…In several long-lived Caenorhabditis elegans strains, such as insulin/IGF-1 receptor daf-2 mutants, enhanced proteostatic mechanisms are accompanied by…”
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The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans by Lapierre, Louis R., De Magalhaes Filho, C. Daniel, McQuary, Philip R., Chu, Chu-Chiao, Visvikis, Orane, Chang, Jessica T., Gelino, Sara, Ong, Binnan, Davis, Andrew E., Irazoqui, Javier E., Dillin, Andrew, Hansen, Malene

“…Autophagy is a cellular recycling process that has an important anti-aging role, but the underlying molecular mechanism is not well understood. The mammalian…”
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Lessons from C. elegans : signaling pathways for longevity by Lapierre, Louis R, Hansen, Malene

“…Recent research using model organisms such as the nematode Caenorhabditis elegans has highlighted a crucial role for several conserved signaling pathways in…”
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Neuronal HLH‐30/TFEB modulates peripheral mitochondrial fragmentation to improve thermoresistance in Caenorhabditis elegans by Wong, Shi Quan, Ryan, Catherine J., Bonal, Dennis M., Mills, Joslyn, Lapierre, Louis R.

“…Transcription factor EB (TFEB) is a conserved master transcriptional activator of autophagy and lysosomal genes that modulates organismal lifespan regulation…”
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Guidelines for monitoring autophagy in Caenorhabditis elegans by Zhang, Hong, Chang, Jessica T, Guo, Bin, Hansen, Malene, Jia, Kailiang, Kovács, Attila L, Kumsta, Caroline, Lapierre, Louis R, Legouis, Renaud, Lin, Long, Lu, Qun, Meléndez, Alicia, O'Rourke, Eyleen J, Sato, Ken, Sato, Miyuki, Wang, Xiaochen, Wu, Fan

“…The cellular recycling process of autophagy has been extensively characterized with standard assays in yeast and mammalian cell lines. In multicellular…”
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Autophagy-mediated longevity is modulated by lipoprotein biogenesis by Seah, Nicole E, de Magalhaes Filho, C Daniel, Petrashen, Anna P, Henderson, Hope R, Laguer, Jade, Gonzalez, Julissa, Dillin, Andrew, Hansen, Malene, Lapierre, Louis R

“…Autophagy-dependent longevity models in C. elegans display altered lipid storage profiles, but the contribution of lipid distribution to life-span extension is…”
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Location, location, location: subcellular protein partitioning in proteostasis and aging by Kumar, Anita V., Lapierre, Louis R.

“…Somatic maintenance and cell survival rely on proper protein homeostasis to ensure reliable functions across the cell and to prevent proteome collapse…”
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Autophagy genes are required for normal lipid levels in C. elegans by Lapierre, Louis R, Silvestrini, Melissa J, Nuñez, Lizbeth, Ames, Kristina, Wong, Sara, Le, Thuc T, Hansen, Malene, Meléndez, Alicia

“…Autophagy is a cellular catabolic process in which various cytosolic components are degraded. For example, autophagy can mediate lipolysis of neutral lipid…”
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