Search Results - "Lapidus, Rena G."

Enhancing the Cytotoxic Effects of PARP Inhibitors with DNA Demethylating Agents – A Potential Therapy for Cancer by Muvarak, Nidal E., Chowdhury, Khadiza, Xia, Limin, Robert, Carine, Choi, Eun Yong, Cai, Yi, Bellani, Marina, Zou, Ying, Singh, Zeba N., Duong, Vu H., Rutherford, Tyler, Nagaria, Pratik, Bentzen, Søren M., Seidman, Michael M., Baer, Maria R., Lapidus, Rena G., Baylin, Stephen B., Rassool, Feyruz V.

“…Poly (ADP-ribose) polymerase inhibitors (PARPis) are clinically effective predominantly for BRCA-mutant tumors. We introduce a mechanism-based strategy to…”
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Gamma Delta T Cell Therapy for Cancer: It Is Good to be Local by Pauza, C David, Liou, Mei-Ling, Lahusen, Tyler, Xiao, Lingzhi, Lapidus, Rena G, Cairo, Cristiana, Li, Haishan

“…Human gamma delta T cells have extraordinary properties including the capacity for tumor cell killing. The major gamma delta T cell subset in human beings is…”
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Analysis of the Mechanisms of Action of Naphthoquinone-Based Anti-Acute Myeloid Leukemia Chemotherapeutics by Lee, Michelle H, Lapidus, Rena G, Ferraris, Dana, Emadi, Ashkan

“…Acute myeloid leukemia (AML) is a neoplastic disorder resulting from clonal proliferation of poorly differentiated immature myeloid cells. Distinct genetic and…”
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Extracellular vesicle PD-L1 dynamics predict durable response to immune-checkpoint inhibitors and survival in patients with non-small cell lung cancer by de Miguel-Perez, Diego, Russo, Alessandro, Arrieta, Oscar, Ak, Murat, Barron, Feliciano, Gunasekaran, Muthukumar, Mamindla, Priyadarshini, Lara-Mejia, Luis, Peterson, Christine B, Er, Mehmet E, Peddagangireddy, Vishal, Buemi, Francesco, Cooper, Brandon, Manca, Paolo, Lapidus, Rena G, Hsia, Ru-Ching, Cardona, Andres F, Naing, Aung, Kaushal, Sunjay, Hirsch, Fred R, Mack, Philip C, Serrano, Maria Jose, Adamo, Vincenzo, Colen, Rivka R, Rolfo, Christian

“…Immune-checkpoint inhibitors (ICIs) changed the therapeutic landscape of patients with lung cancer. However, only a subset of them derived clinical benefit and…”
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Regulation of cisplatin-resistant head and neck squamous cell carcinoma by the SRC/ETS-1 signaling pathway by Yang, Zejia, Liao, Jipei, Carter-Cooper, Brandon A, Lapidus, Rena G, Cullen, Kevin J, Dan, Hancai

“…We investigated the role of the ETS-1 transcription factor in Head and Neck Squamous Cell Carcinoma (HNSCC) in multiple cisplatin-resistant HNSCC cell lines…”
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Dual targeting of glutamine and serine metabolism in acute myeloid leukemia by Hameed, Kanwal M, Bollino, Dominique R, Shetty, Amol C, Carter-Cooper, Brandon, Lapidus, Rena G, Emadi, Ashkan

“…Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy characterized by disrupted blood cell production and function. Recent investigations…”
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SIRT3, a metabolic target linked to ataxia-telangiectasia mutated (ATM) gene deficiency in diffuse large B-cell lymphoma by Bhalla, Kavita, Jaber, Sausan, Reagan, Kayla, Hamburg, Arielle, Underwood, Karen F., Jhajharia, Aditya, Singh, Maninder, Bhandary, Binny, Bhat, Shambhu, Nanaji, Nahid M., Hisa, Ruching, McCracken, Carrie, Creasy, Heather Huot, Lapidus, Rena G., Kingsbury, Tami, Mayer, Dirk, Polster, Brian, Gartenhaus, Ronald B.

“…Inactivation of Ataxia-telangiectasia mutated (ATM) gene results in an increased risk to develop cancer. We show that ATM deficiency in diffuse large B-cell…”
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Erwinia asparaginase (crisantaspase) increases plasma levels of serine and glycine by Bollino, Dominique, Claiborne, J Preston, Hameed, Kanwal, Ma, Xinrong, Tighe, Kayla M, Carter-Cooper, Brandon, Lapidus, Rena G, Strovel, Erin T, Emadi, Ashkan

“…The impact of asparaginases on plasma asparagine and glutamine is well established. However, the effect of asparaginases, particularly those derived from (also…”
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Clinical and laboratory studies of the novel cyclin-dependent kinase inhibitor dinaciclib (SCH 727965) in acute leukemias by Gojo, Ivana, Sadowska, Mariola, Walker, Alison, Feldman, Eric J., Iyer, Swaminathan Padmanabhan, Baer, Maria R., Sausville, Edward A., Lapidus, Rena G., Zhang, Da, Zhu, Yali, Jou, Ying-Ming, Poon, Jennifer, Small, Karen, Bannerji, Rajat

“…Purpose Dinaciclib inhibits cyclin-dependent kinases 1, 2, 5, and 9 with a better therapeutic index than flavopiridol in preclinical studies. This study…”
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Comparison of Neuropathy-Inducing Effects of Eribulin Mesylate, Paclitaxel, and Ixabepilone in Mice by WOZNIAK, Krystyna M, NOMOTO, Kenichi, SLUSHER, Barbara S, LAPIDUS, Rena G, YING WU, CAROZZI, Valentina, CAVALETTI, Guido, HAYAKAWA, Kazuhiro, HOSOKAWA, Satoru, TOWLE, Murray J, LITTLEFIELD, Bruce A

“…Chemotherapy-induced neurotoxicity is a significant problem associated with successful treatment of many cancers. Tubulin is a well-established target of…”
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Long-acting Erwinia chrysanthemi, Pegcrisantaspase, induces alternate amino acid biosynthetic pathways in a preclinical model of pancreatic ductal adenocarcinoma by Bollino, Dominique, Hameed, Kanwal, Bhat, Anusha, Zarrabi, Arveen, Casildo, Andrea, Ma, Xinrong, Tighe, Kayla M, Carter-Cooper, Brandon, Strovel, Erin T, Lapidus, Rena G, Emadi, Ashkan

“…Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease without meaningful therapeutic options beyond the first salvage therapy. Targeting PDAC…”
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Head and neck cancer radiosensitization by the novel poly(ADP-ribose) polymerase inhibitor GPI-15427 by Khan, Khurram, Araki, Koji, Wang, Daiyou, Li, Guayan, Li, Xin, Zhang, Jie, Xu, Weizheng, Hoover, Randall K., Lauter, Susan, O'Malley Jr, Bert, Lapidus, Rena G., Li, Daqing

“…Background In this study, we tested the ability of a novel poly(adenosine diphosphate ribose) polymerase (PARP) inhibitor,…”
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In vivo screening of S100B inhibitors for melanoma therapy by Zimmer, Danna B, Lapidus, Rena G, Weber, David J

“…S100 proteins are markers for numerous cancers, and in many cases high S100 protein levels are a prognostic indicator for poor survival. One such case is…”
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Novel, Broad Spectrum Anticancer Agents Containing the Tricyclic 5:7:5-Fused Diimidazodiazepine Ring System by Kondaskar, Atul, Kondaskar, Shilpi, Kumar, Raj, Fishbein, James C, Muvarak, Nidal, Lapidus, Rena G, Sadowska, Mariola, Edelman, Martin J, Bol, Guus M, Vesuna, Farhad, Raman, Venu, Hosmane, Ramachandra S

“…Synthesis of a series of novel, broad spectrum anticancer agents containing the tricyclic 5:7:5-fused diimidazo[4,5-d:4′,5′-f][1,3]diazepine ring system is…”
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A novel XBP1 variant is highly enriched in cancer tissues and is specifically required for cancer cell survival by Zhong, Yongwang, Yan, Wenjing, Ruan, Jingjing, Fang, Mike, Lapidus, Rena G., Du, Shaojun, Fang, Shengyun

“…XBP1 is a basic leucine zipper (bZIP) transcription factor and a key mediator of the endoplasmic reticulum (ER) stress-activated unfolded protein response…”
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Hydroxylated Dimeric Naphthoquinones Increase the Generation of Reactive Oxygen Species, Induce Apoptosis of Acute Myeloid Leukemia Cells and Are Not Substrates of the Multidrug Resistance Proteins ABCB1 and ABCG2 by Lapidus, Rena G, Carter-Cooper, Brandon A, Sadowska, Mariola, Choi, Eun Yong, Wonodi, Omasiri, Muvarak, Nidal, Natarajan, Karthika, Pidugu, Lakshmi S, Jaiswal, Anil, Toth, Eric A, Rassool, Feyruz V, Etemadi, Arash, Sausville, Edward A, Baer, Maria R, Emadi, Ashkan

“…Selective targeting of the oxidative state, which is a tightly balanced fundamental cellular property, is an attractive strategy for developing novel…”
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Breaking Mitochondrial Fasting for Cancer Treatment: Old Wine in New Bottles by Emadi, Ashkan, Lapidus, Rena G

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Phase I Clinical Trial of DNA Methyltransferase Inhibitor Decitabine and PARP Inhibitor Talazoparib Combination Therapy in Relapsed/Refractory Acute Myeloid Leukemia by Baer, Maria R, Kogan, Aksinija A, Bentzen, Søren M, Mi, Tian, Lapidus, Rena G, Duong, Vu H, Emadi, Ashkan, Niyongere, Sandrine, O'Connell, Casey L, Youngblood, Benjamin A, Baylin, Stephen B, Rassool, Feyruz V

“…Patients with acute myeloid leukemia (AML) unfit for, or resistant to, intensive chemotherapy are often treated with DNA methyltransferase inhibitors (DNMTi)…”
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Pharmacologic induction of innate immune signaling directly drives homologous recombination deficiency by McLaughlin, Lena J., Stojanovic, Lora, Kogan, Aksinija A., Rutherford, Julia L., Choi, Eun Yong, Yen, Ray-Whay Chiu, Xia, Limin, Zou, Ying, Lapidus, Rena G., Baylin, Stephen B., Topper, Michael J., Rassool, Feyruz V.

“…Poly(ADP ribose) polymerase inhibitors (PARPi) have efficacy in triple negative breast (TNBC) and ovarian cancers (OCs) harboring BRCA mutations, generating…”
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PP2A-activating Drugs Enhance FLT3 Inhibitor Efficacy through AKT Inhibition-Dependent GSK-3β-Mediated c-Myc and Pim-1 Proteasomal Degradation by Scarpa, Mario, Singh, Prerna, Bailey, Christopher M, Lee, Jonelle K, Kapoor, Shivani, Lapidus, Rena G, Niyongere, Sandrine, Sangodkar, Jaya, Wang, Yin, Perrotti, Danilo, Narla, Goutham, Baer, Maria R

“…-like tyrosine-like kinase 3 internal tandem duplication (FLT3-ITD) is present in acute myeloid leukemia (AML) in 30% of patients and is associated with short…”
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