Search Results - "Lapato, Dana M."
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Understanding the genetics of peripartum depression: Research challenges, strategies, and opportunities
Published in Frontiers in genetics (17-11-2022)“…Peripartum depression (PD) is a common mood disorder associated with negative outcomes for mother and child. PD is an understudied disorder in psychiatric…”
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Neuron enriched extracellular vesicles’ MicroRNA expression profiles as a marker of early life alcohol consumption
Published in Translational psychiatry (04-04-2024)“…Alcohol consumption may impact and shape brain development through perturbed biological pathways and impaired molecular functions. We investigated the…”
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Maternal biological age assessed in early pregnancy is associated with gestational age at birth
Published in Scientific reports (29-07-2021)“…Maternal age is an established predictor of preterm birth independent of other recognized risk factors. The use of chronological age makes the assumption that…”
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An epigenome-wide association study of early-onset major depression in monozygotic twins
Published in Translational psychiatry (25-08-2020)“…Major depression (MD) is a debilitating mental health condition with peak prevalence occurring early in life. Genome-wide examination of DNA methylation (DNAm)…”
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Replicated umbilical cord blood DNA methylation loci associated with gestational age at birth
Published in Epigenetics (01-11-2020)“…DNA methylation is highly sensitive to in utero perturbations and has an established role in both embryonic development and regulation of gene expression. The…”
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DNA Methylation Research in Autologous Hematopoietic Stem Cell Transplant Population
Published in Biological research for nursing (01-04-2023)“…Despite increased sophistication in DNA methylation (DNAm) measurement and methods, conducting studies in specific populations such as the hematopoietic stem…”
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Heritability, stability, and prevalence of tonic and phasic irritability as indicators of disruptive mood dysregulation disorder
Published in Journal of child psychology and psychiatry (01-09-2019)“…Background Little is known about genetic and environmental influences on the components of disruptive mood dysregulation disorder (DMDD), tonic irritability…”
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Genetic and Environmental Variation in Continuous Phenotypes in the ABCD Study
Published in Behavior genetics (01-02-2023)“…Twin studies yield valuable insights into the sources of variation, covariation and causation in human traits. The ABCD Study® (abcdstudy.org) was designed to…”
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Immune cell markers associated with early life major depressive episodes
Published in Journal of mood and anxiety disorders (01-06-2024)“…Emerging evidence indicates an association between altered immune system functioning, inflammatory response activation, and major depression (MD). This study…”
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Study protocol for the Mindful Moms Study: A randomized controlled trial evaluating a mindful movement intervention for marginalized pregnant people experiencing depression
Published in Contemporary clinical trials (01-09-2023)“…More than 1 in 5 pregnant people in the United States experience depressive symptoms. Although treatments exist, many people remain under- or un-treated due to…”
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A Primer on DNA Methylation and Its Potential to Impact Maternal Depression Risk and Assessment During Pregnancy and the Postpartum
Published in The Journal of perinatal & neonatal nursing (01-01-2021)“…Depression onset during and after pregnancy is prevalent and associated with significant implications for maternal, child, and family health. Although…”
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DNA methylation associated with postpartum depressive symptoms overlaps findings from a genome-wide association meta-analysis of depression
Published in Clinical epigenetics (28-11-2019)“…Perinatal depressive symptoms have been linked to adverse maternal and infant health outcomes. The etiology associated with perinatal depressive…”
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Prospective longitudinal study of the pregnancy DNA methylome: the US Pregnancy, Race, Environment, Genes (PREG) study
Published in BMJ open (01-05-2018)“…PurposeThe goal of the Pregnancy, Race, Environment, Genes study was to understand how social and environmental determinants of health (SEDH),…”
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Genome-wide analysis of hepatic DNA methylation reveals impact of epigenetic aging on xenobiotic metabolism and transport genes in an aged mouse model
Published in GeroScience (01-04-2024)“…Hepatic xenobiotic metabolism and transport decline with age, while intact xenobiotic metabolism is associated with longevity. However, few studies have…”
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Catalyzing communities of research rigour champions
Published in Brain communications (2024)“…The biomedical sciences must maintain and enhance a research culture that prioritizes rigour and transparency. The US National Institute of Neurological…”
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