Search Results - "Lapa, Rui"

Toxicity assessment of ionic liquids with Vibrio fischeri: An alternative fully automated methodology by Costa, Susana P.F., Pinto, Paula C.A.G., Lapa, Rui A.S., Saraiva, M. Lúcia M.F.S.

“…[Display omitted] •A fully automated Vibrio fischeri methodology was developed.•The automated methodology was applied to the evaluation of the toxicity of…”
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PARAFAC under non-negativity constraint is adapted to recover the underlying Beer-Lambert law of the excitation-emission fluorescence matrix measurements acquired from analyte-triggered semiconductor QDs photoluminescence modulation. When and why? by Mazivila, Sarmento J., Soares, Jose X., Lapa, Rui A.S., Saraiva, M. Lúcia M.F.S., Fernandes, Jose O., Cunha, Sara C., Santos, Joao L.M.

“…Analyte-triggered semiconductor quantum dots (QDs) modulation in the presence of non-consistently responsive fluorescent species represents a challenging…”
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Added value of ionic liquids in a biocatalytic process: An automatic approach by Prots, Svitlana, Passos, Marieta L.C., Lapa, Rui A.S., Saraiva, M. Lúcia M.F.S.

“…[Display omitted] •New analytical tool for the automation of enzymatic assays in ILs medium.•Structures of the ionic liquids and their effect on the…”
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New In Vitro-In Silico Approach for the Prediction of In Vivo Performance of Drug Combinations by Correia, Cristiana, Ferreira, Abigail, Santos, Joana, Lapa, Rui, Yliperttula, Marjo, Urtti, Arto, Vale, Nuno

“…Pharmacokinetic (PK) studies improve the design of dosing regimens in preclinical and clinical settings. In complex diseases like cancer, single-agent…”
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Permeability of Gemcitabine and PBPK Modeling to Assess Oral Administration by Ferreira, Abigail, Lapa, Rui, Vale, Nuno

“…Gemcitabine is a nucleoside analog effective against several solid tumors. Standard treatment consists of an intravenous infusion over 30 min. This is an…”
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In Silico Pharmacokinetic Study of Vancomycin Using PBPK Modeling and Therapeutic Drug Monitoring by Ferreira, Abigail, Martins, Helena, Oliveira, José C, Lapa, Rui, Vale, Nuno

“…Vancomycin has been in clinical use for nearly 50 years and remains the first-line treatment option for Gram-positive infections, including…”
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A retrospective study comparing creatinine clearance estimation using different equations on a population-based cohort by Ferreira, Abigail, Lapa, Rui, Vale, Nuno

“…Renal elimination is an important part of drugs' excretion. At the same time, renal function can be impaired as a side effect of medication, particularly…”
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Combination of Gemcitabine with Cell-Penetrating Peptides: A Pharmacokinetic Approach Using In Silico Tools by Ferreira, Abigail, Lapa, Rui, Vale, Nuno

“…Gemcitabine is an anticancer drug used to treat a wide range of solid tumors and is a first line treatment for pancreatic cancer. Our group has previously…”
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Fluorometric kinetic determination of aflatoxin B1 by combining Cd-free ternary quantum dots induced photocatalysis and chemometrics by Castro, Rafael C., Páscoa, Ricardo N.M.J., Saraiva, M. Lúcia M.F.S., Lapa, Rui A.S., Fernandes, José O., Cunha, Sara C., Santos, João L.M., Ribeiro, David S.M.

“…[Display omitted] •AIS QDs ability to produce ROS was explored for AFB1 determination.•AFB1 degradation products were more fluorescent than the mycotoxin…”
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PBPK Modeling and Simulation of Antibiotics Amikacin, Gentamicin, Tobramycin, and Vancomycin Used in Hospital Practice by Ferreira, Abigail, Martins, Helena, Oliveira, José Carlos, Lapa, Rui, Vale, Nuno

“…The importance of closely observing patients receiving antibiotic therapy, performing therapeutic drug monitoring (TDM), and regularly adjusting dosing…”
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CMOS arrays as chemiluminescence detectors on microfluidic devices by Rodrigues, Eunice R. G. O, Lapa, Rui A. S

“…A simple, low-cost process to integrate complementary metal oxide semiconductor array detectors (CMOSAD) for chemiluminescence is presented, evaluated, and…”
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Multicommutation in flow analysis: concepts, applications and trends by Rocha, Fábio R.P, Reis, Boaventura F, Zagatto, Elias A.G, Lima, José L.F.C, Lapa, Rui A.S, Santos, João L.M

“…Multicommutation refers to flow systems designed with discrete computer-controlled commutators resulting in flow networks in which all the steps involved in…”
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Multi-pumping in flow analysis: concepts, instrumentation, potentialities by Lapa, Rui A.S, Lima, José L.F.C, Reis, Boaventura F, Santos, João L.M, Zagatto, Elias A.G

“…A novel strategy for the implementation of flow-based analytical procedures using several micropumps is proposed. The pumps are switched individually or in…”
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Development of Flow Systems by Direct-milling on Poly(methyl methacrylate) Substrates Using UV-Photopolymerization as Sealing Process by Eunice R. G. O. RODRIGUES, LAPA, Rui A. S.

“…An alternative process for the design and construction of fluidic devices is presented. Several sealing processes were studied, as well as the hydrodynamic…”
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Development of micro-flow devices by direct-milling on poly(methyl methacrylate) substrates with integrated optical detection by Rodrigues, Eunice R. G. O, Lapa, Rui A. S

“…The development of micro-flow devices by direct-milling on poly(methyl methacrylate) (PMMA) substrates and incorporating the optic detector into the same…”
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Fluorimetric determination of isoniazid by oxidation with cerium(IV) in a multicommutated flow system by Lapa, Rui A.S, Lima, José L.F.C, Santos, João L.M

“…A multicommutated flow system for the indirect fluorimetric determination of isoniazid was proposed. The analytical procedure was based on the oxidation of…”
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Development of a sequential injection analysis system for the simultaneous biosensing of glucose and ethanol in bioreactor fermentation by Lapa, Rui A.S, Lima, José L.F.C, Pinto, Ivone V.O.S

“…An on-line sequential injection analysis system using amperometric detection for the simultaneous monitoring of glucose and ethanol in fermentations media is…”
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Chemiluminometric determination of carvedilol in a multi-pumping flow system by Pires, Cherrine K., Marques, Karine L., Santos, João L.M., Lapa, Rui A.S., Lima, José L.F.C., Zagatto, Elias A.G.

“…In this work a simple, fast, sensitive and selective flow-based procedure for the chemiluminometric determination of carvedilol, a recent non-cardioselective…”
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Permeability evaluation of gemcitabine-CPP6 conjugates in Caco-2 cells by Ferreira, Abigail, Moreira, Sara, Lapa, Rui, Vale, Nuno

“…Cancer is one of the most alarming diseases due to its high mortality and still increasing incidence rate. Currently available treatments for this condition…”
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Automatic Flow System with Voltammetric Detection for Diacetyl Monitoring during Brewing Process by Rodrigues, Pedro G, Rodrigues, José A, Barros, Aquiles A, Lapa, Rui A. S, Lima, José L. F. C, Machado Cruz, J. M, Ferreira, A. A

“…Diacetyl can be determined by adsorptive stripping voltammetry after derivatization with o-phenylenediamine. The method may be applicable to the determination…”
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