Anti-inflammatory and hemostatic effects of Linaria reflexa Desf

Anti-inflammatory and hemostatic effects of Linaria reflexa Desf

The work presented here was aimed to investigate the in vivo anti-inflammatory and in vitro hemostatic activities of Linaria reflexa extract and to establish the relationship between its bioactivity and chemical composition. Twenty-three secondary metabolites were identified, most of them are good a...

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Bibliographic Details
Published in:Natural product research Vol. 35; no. 16; pp. 2778 - 2783
Main Authors: Cheriet, Thamere, Hanfer, Mourad, Mancini, Ines, Benelhadj, Samiha, Laouas, Nour Essabah, Ameddah, Souad, Menad, Ahmed, Seghiri, Ramdane
Format: Journal Article
Language:English
Published: England Taylor & Francis 12-08-2021
Taylor & Francis Ltd
Subjects:
acids
anti-inflammatory
Anti-inflammatory agents
Biological activity
Butanol
Chemical composition
Coagulation
Edema
Flavone glycosides
flavones
Flavonoids
Free radicals
Glycosides
hemostatic
In vivo methods and tests
Inflammation
Inflammatory response
Injury prevention
Linaria
Linaria reflexa
Lipid peroxidation
Lipids
Malondialdehyde
Metabolites
Peroxidase
Peroxidation
Secondary metabolites
anti-inflammatory
flavones
hemostatic
acids
Linaria reflexa
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Summary:The work presented here was aimed to investigate the in vivo anti-inflammatory and in vitro hemostatic activities of Linaria reflexa extract and to establish the relationship between its bioactivity and chemical composition. Twenty-three secondary metabolites were identified, most of them are good anti-inflammatory agents, in line with data by carrageenin-induced rat paw edema assays of the n-butanol extract showing high anti-inflammatory inhibition (63.90%) of edema swelling in the rat paw at the dose 200 mg/kg after 4 h. Furthermore, both extent of inflammatory response and tissue injury were prevented keeping the levels of rate myeloperoxidase (60.16%) and of malondialdehyde, which is the final product of lipid peroxidation generated by free radicals (58.58%). The same extract showed also a remarkable hemostatic effect established by measuring the coagulation time of decalcified plasma (45 s), related to its flavonoid glycosides content.
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ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2019.1663516