Search Results - "Lao, Julie"

Functionally selective signaling and broad metabolic benefits by novel insulin receptor partial agonists by Wu, Margaret, Carballo-Jane, Ester, Zhou, Haihong, Zafian, Peter, Dai, Ge, Liu, Mindy, Lao, Julie, Kelly, Terri, Shao, Dan, Gorski, Judith, Pissarnitski, Dmitri, Kekec, Ahmet, Chen, Ying, Previs, Stephen F., Scapin, Giovanna, Gomez-Llorente, Yacob, Hollingsworth, Scott A., Yan, Lin, Feng, Danqing, Huo, Pei, Walford, Geoffrey, Erion, Mark D., Kelley, David E., Lin, Songnian, Mu, James

“…Insulin analogs have been developed to treat diabetes with focus primarily on improving the time action profile without affecting ligand-receptor interaction…”
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A New Strategy to Reduce Influenza Escape: Detecting Therapeutic Targets Constituted of Invariance Groups by Lao, Julie, Vanet, Anne

“…The pathogenicity of the different flu species is a real public health problem worldwide. To combat this scourge, we established a method to detect drug…”
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Author Correction: Functionally selective signaling and broad metabolic benefits by novel insulin receptor partial agonists by Wu, Margaret, Carballo-Jane, Ester, Zhou, Haihong, Zafian, Peter, Dai, Ge, Liu, Mindy, Lao, Julie, Kelly, Terri, Shao, Dan, Gorski, Judith, Pissarnitski, Dmitri, Kekec, Ahmet, Chen, Ying, Previs, Stephen F., Scapin, Giovanna, Gomez-Llorente, Yacob, Hollingsworth, Scott A., Yan, Lin, Feng, Danqing, Huo, Pei, Walford, Geoffrey, Erion, Mark D., Kelley, David E., Lin, Songnian, Mu, James

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FirmiData: a set of 40 genomes of Firmicutes with a curated annotation of ICEs and IMEs by Guédon, Gérard, Lao, Julie, Payot, Sophie, Lacroix, Thomas, Chiapello, Hélène, Leblond-Bourget, Nathalie

“…'Integrative and Conjugative Elements' (ICEs) and 'Integrative and Mobilizable Elements' (IMEs) are two classes of mobile genetic elements that are complex to…”
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Prevalence and mobility of integrative and conjugative elements within a Streptomyces natural population by Choufa, Caroline, Tidjani, Abdoul-Razak, Gauthier, Anthony, Harb, Manar, Lao, Julie, Leblond-Bourget, Nathalie, Vos, Michiel, Leblond, Pierre, Bontemps, Cyril

“…Horizontal Gene Transfer (HGT) is a powerful force generating genomic diversity in bacterial populations. HGT in Streptomyces is in large part driven by…”
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Glucagon like receptor 1/ glucagon dual agonist acutely enhanced hepatic lipid clearance and suppressed de novo lipogenesis in mice by More, Vijay R, Lao, Julie, McLaren, David G, Cumiskey, Anne-Marie, Murphy, Beth Ann, Chen, Ying, Previs, Stephen, Stout, Steven, Patel, Rajesh, Satapati, Santhosh, Li, Wenyu, Kowalik, Edward, Szeto, Daphne, Nawrocki, Andrea, Pocai, Alessandro, Wang, Liangsu, Carrington, Paul

“…Lipid lowering properties of glucagon have been reported. Blocking glucagon signaling leads to rise in plasma LDL levels. Here, we demonstrate the lipid…”
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Comparative Genome Analysis of Enterococcus cecorum Reveals Intercontinental Spread of a Lineage of Clinical Poultry Isolates by Laurentie, Jeanne, Loux, Valentin, Hennequet-Antier, Christelle, Chambellon, Emilie, Deschamps, Julien, Trotereau, Angélina, Furlan, Sylviane, Darrigo, Claire, Kempf, Florent, Lao, Julie, Milhes, Marine, Roques, Céline, Quinquis, Benoit, Vandecasteele, Céline, Boyer, Roxane, Bouchez, Olivier, Repoila, Francis, Le Guennec, Jean, Chiapello, Hélène, Briandet, Romain, Helloin, Emmanuelle, Schouler, Catherine, Kempf, Isabelle, Serror, Pascale

“…Enterococcus cecorum is an emerging pathogen responsible for osteomyelitis, spondylitis, and femoral head necrosis causing animal suffering and mortality and…”
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A New Integrative and Mobilizable Element Is a Major Contributor to Tetracycline Resistance in Streptococcus dysgalactiae subsp. equisimilis by López de Egea, Guillem, González-Díaz, Aida, Guédon, Gérard, Lao, Julie, Berbel, Dàmaris, Casabella, Antonio, Marimón, José María, Cercenado, Emilia, Fernández-Delgado, Lucía, Chiapello, Hélène, Lacroix, Thomas, Domínguez, María Ángeles, Leblond-Bourget, Nathalie, Ardanuy, Carmen

“…Tetracycline resistance in streptococci is mainly due to ribosomal protection mediated by the (M) gene that is usually located in the integrative and…”
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Reduced sensitivity to diet-induced obesity in mice carrying a mutant 5-HT6 receptor by Frassetto, Andrea, Zhang, Jiaping, Lao, Julie Z, White, Amanda, Metzger, Joseph M, Fong, Tung M, Chen, Richard Z

“…Abstract We investigated the feeding behavior of mice carrying a non-functional 5-hydroxytryptamine-6 receptor (5-HT6 ). Homozygous mutant mice on C57BL/6…”
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Acute hemodynamic and renal effects of glucagon-like peptide 1 analog and dipeptidyl peptidase-4 inhibitor in rats by Zhou, Xiaoyan, Huang, Chin-hu, Lao, Julie, Pocai, Alessandro, Forrest, Gail, Price, Olga, Roy, Sophie, Kelley, David E, Sullivan, Kathleen A, Forrest, Michael J

“…Glucagon-like peptide 1 (GLP-1) analogs and dipeptidyl peptidase-4 (DPP4) inhibitors are a newer class of antidiabetics named as incretin-based therapy. In…”
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Pharmacological evaluation of LH-21, a newly discovered molecule that binds to cannabinoid CB1 receptor by Chen, Richard Z., Frassetto, Andrea, Lao, Julie Z., Huang, Ruey-Ruey C., Xiao, Jing C., Clements, Matthew J., Walsh, Thomas F., Hale, Jeffrey J., Wang, Junying, Tong, Xinchun, Fong, Tung M.

“…LH-21 (5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole) was previously reported as a neutral antagonist at the cannabinoid CB1 receptor…”
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Furo[2,3- b]pyridine-based cannabinoid-1 receptor inverse agonists: Synthesis and biological evaluation. Part 1 by Debenham, John S., Madsen-Duggan, Christina B., Toupence, Richard B., Walsh, Thomas F., Wang, Junying, Tong, Xinchun, Kumar, Sanjeev, Lao, Julie, Fong, Tung M., Xiao, Jing Chen, Huang, Cathy R.-R.C., Shen, Chun-Pyn, Feng, Yue, Marsh, Donald J., Stribling, D. Sloan, Shearman, Lauren P., Strack, Alison M., Goulet, Mark T.

“…The synthesis, SAR and binding affinities of cannabinoid-1 receptor (CB1R) inverse agonists based on furo[2,3- b]pyridine scaffolds are described. Food intake,…”
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Discovery of N-[(1S,2S)-3-(4-Chlorophenyl)-2- (3-cyanophenyl)-1-methylpropyl]-2-methyl-2- {[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), a Novel, Acyclic Cannabinoid-1 Receptor Inverse Agonist for the Treatment of Obesity by Lin, Linus S, Lanza, Thomas J, Jewell, James P, Liu, Ping, Shah, Shrenik K, Qi, Hongbo, Tong, Xinchun, Wang, Junying, Xu, Suoyu S, Fong, Tung M, Shen, Chun-Pyn, Lao, Julie, Xiao, Jing Chen, Shearman, Lauren P, Stribling, D. Sloan, Rosko, Kimberly, Strack, Alison, Marsh, Donald J, Feng, Yue, Kumar, Sanjeev, Samuel, Koppara, Yin, Wenji, Van der Ploeg, Lex H. T, Goulet, Mark T, Hagmann, William K

“…The discovery of novel acyclic amide cannabinoid-1 receptor inverse agonists is described. They are potent, selective, orally bioavailable, and active in…”
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Pyridopyrimidine based cannabinoid-1 receptor inverse agonists: Synthesis and biological evaluation by Debenham, John S., Madsen-Duggan, Christina B., Wang, Junying, Tong, Xinchun, Lao, Julie, Fong, Tung M., Schaeffer, Marie-Therese, Xiao, Jing Chen, Huang, Cathy C.R.-R., Shen, Chun-Pyn, Sloan Stribling, D., Shearman, Lauren P., Strack, Alison M., Euan MacIntyre, D., Hale, Jeffrey J., Walsh, Thomas F.

“…The synthesis, SAR and binding affinities are described for cannabinoid-1 receptor (CB1R) specific inverse agonists based on pyridopyrimidine and…”
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Synthesis and activity of 4,5-diarylimidazoles as human CB1 receptor inverse agonists by Plummer, Christopher W., Finke, Paul E., Mills, Sander G., Wang, Junying, Tong, Xinchun, Doss, George A., Fong, Tung M., Lao, Julie Z., Schaeffer, Marie-Therese, Chen, Jing, Shen, Chun-Pyn, Stribling, D. Sloan, Shearman, Lauren P., Strack, Alison M., Van der Ploeg, Lex H.T.

“…The synthesis and structure–activity relationships for a series of substituted 4,5-diphenylimidazole-2-carboxamide derivatives 2b as selective, orally active…”
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1-Sulfonyl-4-acylpiperazines as Selective Cannabinoid-1 Receptor (CB1R) Inverse Agonists for the Treatment of Obesity by Vachal, Petr, Fletcher, Joan M, Fong, Tung M, Huang, Cathy C. R.-R, Lao, Julie, Xiao, Jing C, Shen, Chun-Pyn, Strack, Alison M, Shearman, Lauren, Stribling, Sloan, Chen, Richard Z, Frassetto, Andrea, Tong, Xinchun, Wang, Junying, Ball, Richard G, Tsou, Nancy N, Hickey, Gerard J, Thompson, Donald F, Faidley, Terry D, Nicolich, Susan, Achanfuo-Yeboah, Joana, Hora, Donald F, Hale, Jeffrey J, Hagmann, William K

“…A novel series of 1-sulfonyl-4-acylpiperazines as selective cannabinoid-1 receptor (CB1R) inverse agonists was discovered through high throughput screening…”
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MK-7128, a novel CB1 receptor inverse agonist, improves scopolamine-induced learning and memory deficits in mice by Dillon, Gregory M, Lubbers, Laura S, Ferguson, Mitchell T, Lao, Julie Z, Huang, Ruey-Ruey C, Xiao, Jing C, Fong, Tung M, Hale, Jeffrey J, Rupprecht, Kathleen, Miao, Shouwu, Rowe, Blake A, Kornecook, Thomas J, Dodart, Jean-Cosme

“…Cannabinoid receptors (CBRs) play an important role in a variety of physiological functions and have been considered drug targets for obesity and psychiatric…”
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The μ-opioid receptor subtype is required for the anorectic effect of an opioid receptor antagonist by Zhang, Jiaping, Frassetto, Andrea, Huang, Ruey-Ruey C., Lao, Julie Z., Pasternak, Alexander, Wang, Sheng-ping, Metzger, Joseph M., Strack, Alison M., Fong, Tung M., Chen, Richard Z.

“…A diaryl ether derivative, (6-(4-{[(3-methylbutyl)amino]methyl}phenoxy)nicotinamide, was prepared and investigated for its biochemical properties at cloned…”
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Synthesis and evaluation of N-[(1 S,2 S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-aminopropanamide as human cannabinoid-1 receptor (CB1R) inverse agonists by Du, Wu, Jewell, James P., Lin, Linus S., Colandrea, Vincent J., Xiao, Jing C., Lao, Julie, Shen, Chun-Pyn, Bateman, Thomas J., Reddy, Vijay B.G., Ha, Sookhee N., Shah, Shrenik K., Fong, Tung M., Hale, Jeffrey J., Hagmann, William K.

“…A series of N-[(1 S,2 S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-aminopropanamides were prepared by a divergent synthesis. Their…”
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Substituted acyclic sulfonamides as human cannabinoid-1 receptor inverse agonists by Armstrong, Helen E., Galka, Amy, Lin, Linus S., Lanza, Thomas J., Jewell, James P., Shah, Shrenik K., Guthikonda, Ravi, Truong, Quang, Chang, Linda L., Quaker, Grace, Colandrea, Vincent J., Tong, Xinchun, Wang, Junying, Xu, Sherry, Fong, Tung M., Shen, Chun-Pyn, Lao, Julie, Chen, Jing, Shearman, Lauren P., Stribling, D. Sloan, Rosko, Kimberly, Strack, Alison, Ha, Sookhee, der Ploeg, Lex Van, Goulet, Mark T., Hagmann, William K.

“…Sulfonamide analogues of the potent CB1R inverse agonist 2 (Taranabant) were optimized for CB1R activity. Sulfonamide analogues of the potent CB1R inverse…”
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