MERAV: a tool for comparing gene expression across human tissues and cell types

The oncogenic transformation of normal cells into malignant, rapidly proliferating cells requires major alterations in cell physiology. For example, the transformed cells remodel their metabolic processes to supply the additional demand for cellular building blocks. We have recently demonstrated ess...

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Bibliographic Details
Published in:	Nucleic acids research Vol. 44; no. D1; pp. D560 - D566
Main Authors:	Shaul, Yoav D, Yuan, Bingbing, Thiru, Prathapan, Nutter-Upham, Andy, McCallum, Scott, Lanzkron, Carolyn, Bell, George W, Sabatini, David M
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 04-01-2016
Subjects:	Cell Line Cell Line, Tumor Database Issue Databases, Genetic Gene Expression Profiling - standards Humans Internet Metabolic Networks and Pathways - genetics Neoplasms - genetics Neoplasms - metabolism Oligonucleotide Array Sequence Analysis - standards Software
Online Access:	Get full text
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Summary:	The oncogenic transformation of normal cells into malignant, rapidly proliferating cells requires major alterations in cell physiology. For example, the transformed cells remodel their metabolic processes to supply the additional demand for cellular building blocks. We have recently demonstrated essential metabolic processes in tumor progression through the development of a methodological analysis of gene expression. Here, we present the Metabolic gEne RApid Visualizer (MERAV, http://merav.wi.mit.edu), a web-based tool that can query a database comprising ∼4300 microarrays, representing human gene expression in normal tissues, cancer cell lines and primary tumors. MERAV has been designed as a powerful tool for whole genome analysis which offers multiple advantages: one can search many genes in parallel; compare gene expression among different tissue types as well as between normal and cancer cells; download raw data; and generate heatmaps; and finally, use its internal statistical tool. Most importantly, MERAV has been designed as a unique tool for analyzing metabolic processes as it includes matrixes specifically focused on metabolic genes and is linked to the Kyoto Encyclopedia of Genes and Genomes pathway search.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0305-1048 1362-4962
DOI:	10.1093/nar/gkv1337