Search Results - "Lanza, Diane L."

Transient receptor potential vanilloid 1 agonists cause endoplasmic reticulum stress and cell death in human lung cells by Thomas, Karen C, Sabnis, Ashwini S, Johansen, Mark E, Lanza, Diane L, Moos, Philip J, Yost, Garold S, Reilly, Christopher A

“…Transient receptor potential vanilloid 1 (TRPV1) is a calcium-selective ion channel expressed in human lung cells. We show that activation of the intracellular…”
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Selective Dehydrogenation/Oxygenation of 3-Methylindole by Cytochrome P450 Enzymes by LANZA, Diane L, YOST, Garold S

“…3-Methylindole (3 MI) is a selective pulmonary toxicant, and cytochrome P450 (P450) bioactivation of 3 MI, through hydroxylation, epoxidation, or…”
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Calcium-dependent and independent mechanisms of capsaicin receptor (TRPV1)-mediated cytokine production and cell death in human bronchial epithelial cells by Reilly, Christopher A., Johansen, Mark E., Lanza, Diane L., Lee, Jeewoo, Lim, Ju-Ok, Yost, Garold S.

“…Activation of the capsaicin receptor (VR1 or TRPV1) in bronchial epithelial cells by capsaicinoids and other vanilloids promotes pro‐inflammatory cytokine…”
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BIOACTIVATION OF 1,1-DICHLOROETHYLENE TO ITS EPOXIDE BY CYP2E1 AND CYP2F ENZYMES by SIMMONDS, Andrea C, REILLY, Christopher A, BALDWIN, R. Michael, GHANAYEM, Burhan I, LANZA, Diane L, YOST, Garold S, COLLINS, Kathy S, FORKERT, Poh-Gek

“…1,1-Dichloroethylene (DCE) exposure to mice elicits lung toxicity that selectively targets bronchiolar Clara cells. The toxicity is mediated by DCE metabolites…”
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SP1 AND SP3 REGULATE BASAL TRANSCRIPTION OF THE HUMAN CYP2F1 GENE by JIE WAN, CARR, Brian A, CUTLER, N. Shane, LANZA, Diane L, HINES, Ronald N, YOST, Garold S

“…Selective transcription of the human CYP2F1 gene in lung tissues may control the susceptibilities of this organ to diverse pneumotoxicants and lung…”
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Dehydrogenation of indoline by cytochrome P450 enzymes: a novel "aromatase" process by Sun, Hao, Ehlhardt, William J, Kulanthaivel, Palaniappan, Lanza, Diane L, Reilly, Christopher A, Yost, Garold S

“…Indoline derivatives possess therapeutic potential within a variety of drug candidates. In this study, we found that indoline is aromatized by cytochrome P450…”
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Capsaicinoids Cause Inflammation and Epithelial Cell Death through Activation of Vanilloid Receptors by Reilly, Christopher A., Taylor, Jack L., Lanza, Diane L., Carr, Brian A., Crouch, Dennis J., Yost, Garold S.

“…Capsaicinoids, found in less-than-lethal self-defense weapons, have been associated with respiratory failure and death in exposed animals and people. The…”
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Effects of the differentiated keratinocyte phenotype on expression levels of CYP1–4 family genes in human skin cells by Du, Liping, Neis, Mark M., Ladd, Patricia A., Lanza, Diane L., Yost, Garold S., Keeney, Diane S.

“…Epoxyeicosatrienoic acids produced by mouse CYP2B19 have been implicated in mechanisms regulating epidermal cornification (Ladd, P.A., Du, L., Capdevila, J.H.,…”
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Inflammatory Cytokines and Cell Death in BEAS-2B Lung Cells Treated with Soil Dust, Lipopolysaccharide, and Surface-Modified Particles by Veranth, John M., Reilly, Christopher A., Veranth, Martha M., Moss, Tyler A., Langelier, Charles R., Lanza, Diane L., Yost, Garold S.

“…Cultured human lung epithelial cells (BEAS-2B) were treated in vitro with PM2.5-enriched particles of soil-derived mineral dust from nine sites in the western…”
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Specific Dehydrogenation of 3-Methylindole and Epoxidation of Naphthalene by Recombinant Human CYP2F1 Expressed in Lymphoblastoid Cells by LANZA, D. L, CODE, E, CRESPI, C. L, GONZALEZ, F. J, YOST, G. S

“…3-Methylindole (3MI) is a naturally occurring pulmonary toxin that requires metabolic activation. Previous studies have shown that 3MI-induced pneumotoxicity…”
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Evidence Supporting the Formation of 2,3-Epoxy-3-methylindoline:  A Reactive Intermediate of the Pneumotoxin 3-Methylindole by Skordos, Konstantine W, Skiles, Gary L, Laycock, John D, Lanza, Diane L, Yost, Garold S

“…The existence of a cytochrome P450-dependent 2,3-epoxide of the potent pneumotoxin 3-methylindole was indirectly confirmed using stable isotope techniques and…”
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Cloning and Expression of CYP2F3,a Cytochrome P450 That Bioactivates the Selective Pneumotoxins 3-Methylindole and Naphthalene by Wang, Huifen, Lanza, Diane L., Yost, Garold S.

“…Members of the CYP2F gene subfamily are selectively expressed in lung tissues and have been implicated as important catalysts in the formation of reactive…”
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Association of 3-methyleneindolenine, a toxic metabolite of 3-methylindole, with acute interstitial pneumonia in feedlot cattle by Loneragan, G H, Gould, D H, Mason, G L, Garry, F B, Yost, G S, Lanza, D L, Miles, D G, Hoffman, B W, Mills, L J

“…To compare concentrations of 3-methyleneindolenine (3MEIN) in lung tissues obtained from feedlot cattle that died as a result of acute interstitial pneumonia…”
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