Search Results - "Lanyon, Lorraine"

Acoustic Ejection Mass Spectrometry for High-Throughput Analysis by Zhang, Hui, Liu, Chang, Hua, Wenyi, Ghislain, Lucien P, Liu, Jianhua, Aschenbrenner, Lisa, Noell, Stephen, Dirico, Kenneth J, Lanyon, Lorraine F, Steppan, Claire M, West, Mike, Arnold, Don W, Covey, Thomas R, Datwani, Sammy S, Troutman, Matthew D

“…We describe a mass spectrometry (MS) analytical platform resulting from the novel integration of acoustic droplet ejection (ADE) technology, an open-port…”
Get full text

Class I HDAC inhibition is a novel pathway for regulating astrocytic apoE secretion by Dresselhaus, Erica, Duerr, James M, Vincent, Fabien, Sylvain, Emily K, Beyna, Mercedes, Lanyon, Lorraine F, LaChapelle, Erik, Pettersson, Martin, Bales, Kelly R, Ramaswamy, Gayathri

“…Despite the important role of apolipoprotein E (apoE) secretion from astrocytes in brain lipid metabolism and the strong association of apoE4, one of the human…”
Get full text

Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging by Liang, Steven H., Chen, Jinshan Michael, Normandin, Marc D., Chang, Jeanne S., Chang, George C., Taylor, Christine K., Trapa, Patrick, Plummer, Mark S., Para, Kimberly S., Conn, Edward L., Lopresti-Morrow, Lori, Lanyon, Lorraine F., Cook, James M., Richter, Karl E. G., Nolan, Charlie E., Schachter, Joel B., Janat, Fouad, Che, Ye, Shanmugasundaram, Veerabahu, Lefker, Bruce A., Enerson, Bradley E., Livni, Elijahu, Wang, Lu, Guehl, Nicolas J., Patnaik, Debasis, Wagner, Florence F., Perlis, Roy, Holson, Edward B., Haggarty, Stephen J., El Fakhri, Georges, Kurumbail, Ravi G., Vasdev, Neil

“…Glycogen synthase kinase‐3 (GSK‐3) regulates multiple cellular processes in diabetes, oncology, and neurology…”
Get full text

Identification of a Novel Positron Emission Tomography (PET) Ligand for Imaging β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE-1) in Brain by Zhang, Lei, Chen, Laigao, Dutra, Jason K, Beck, Elizabeth M, Nag, Sangram, Takano, Akihiro, Amini, Nahid, Arakawa, Ryosuke, Brodney, Michael A, Buzon, Leanne M, Doran, Shawn D, Lanyon, Lorraine F, McCarthy, Timothy J, Bales, Kelly R, Nolan, Charles E, O’Neill, Brian T, Schildknegt, Klaas, Halldin, Christer, Villalobos, Anabella

“…Alzheimer’s disease (AD) is characterized by accumulation of β-amyloid (Aβ) plaques and neurofibrillary tau tangles in the brain. β-Site amyloid precursor…”
Get full text

INHIBITION OF BACE2 AFFECTS MELANOSOME ULTRASTRUCTURE AND CAUSES OF HYPOPIGMENTATION by Nolan, Charles E, Karanian, David, Chang, Cheng, Lanyon, Lorraine F, Houle, Christopher, Pandher, Karamjeet, Boucher, Germaine, Hales, Katherine, Gonzales, Cathleen, Ambroise, Claude, Doran, Shawn, Bales, Kelly R, Brodney, Michael

Get full text

Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging by Liang, Steven H., Chen, Jinshan Michael, Normandin, Marc D., Chang, Jeanne S., Chang, George C., Taylor, Christine K., Trapa, Patrick, Plummer, Mark S., Para, Kimberly S., Conn, Edward L., Lopresti-Morrow, Lori, Lanyon, Lorraine F., Cook, James M., Richter, Karl E. G., Nolan, Charlie E., Schachter, Joel B., Janat, Fouad, Che, Ye, Shanmugasundaram, Veerabahu, Lefker, Bruce A., Enerson, Bradley E., Livni, Elijahu, Wang, Lu, Guehl, Nicolas J., Patnaik, Debasis, Wagner, Florence F., Perlis, Roy, Holson, Edward B., Haggarty, Stephen J., El Fakhri, Georges, Kurumbail, Ravi G., Vasdev, Neil

“…Glycogen synthase kinase‐3 (GSK‐3) regulates multiple cellular processes in diabetes, oncology, and neurology…”
Get full text

Using single-point pharmacokinetic/pharmacodynamic (PK/PD) analyses to support early discovery of inhibitors of β-site APP cleaving enzyme 1 (BACE1) by Lu, Yasong, Liu, Jianhua, Nelson, Frederick, Ambroise, Claude, Fisher, Katherine, Hajos-Korcsok, Eva, Noell, Stephen, Nolan, Charles E, Oborski, Christine E, Lanyon, Lorraine F, Christoffersen, Curt, Hannah, Divine, Efremov, Ivan, Helal, Chris, Brodney, Michael A, O'Neill, Brian T

Get full text

Substituted 6-phenyl-pyridin-2-ylamines: selective and potent inhibitors of neuronal nitric oxide synthase by Nason, Deane M, Heck, Steven D, Bodenstein, Mathew S, Lowe, John A, Nelson, Robert B, Liston, Dane R, Nolan, Charles E, Lanyon, Lorraine F, Ward, Karen M, Volkmann, Robert A

“…The synthesis and nNOS/eNOS activity of 6-(4-(dimethylaminoalkyl)/-(4-(dimethylaminoalkoxy)-5-ethyl-2-methoxyphenyl)-pyridin-2-ylamines and…”
Get full text

Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality by Butler, Christopher R, Ogilvie, Kevin, Martinez-Alsina, Luis, Barreiro, Gabriela, Beck, Elizabeth M, Nolan, Charles E, Atchison, Kevin, Benvenuti, Eric, Buzon, Leanne, Doran, Shawn, Gonzales, Cathleen, Helal, Christopher J, Hou, Xinjun, Hsu, Mei-Hui, Johnson, Eric F, Lapham, Kimberly, Lanyon, Lorraine, Parris, Kevin, O’Neill, Brian T, Riddell, David, Robshaw, Ashley, Vajdos, Felix, Brodney, Michael A

“…A growing subset of β-secretase (BACE1) inhibitors for the treatment of Alzheimer’s disease (AD) utilizes an anilide chemotype that engages a key residue…”
Get full text

Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation by O’Neill, Brian T, Beck, Elizabeth M, Butler, Christopher R, Nolan, Charles E, Gonzales, Cathleen, Zhang, Lei, Doran, Shawn D, Lapham, Kimberly, Buzon, Leanne M, Dutra, Jason K, Barreiro, Gabriela, Hou, Xinjun, Martinez-Alsina, Luis A, Rogers, Bruce N, Villalobos, Anabella, Murray, John C, Ogilvie, Kevin, LaChapelle, Erik A, Chang, Cheng, Lanyon, Lorraine F, Steppan, Claire M, Robshaw, Ashley, Hales, Katherine, Boucher, Germaine G, Pandher, Karamjeet, Houle, Christopher, Ambroise, Claude W, Karanian, David, Riddell, David, Bales, Kelly R, Brodney, Michael A

“…A major challenge in the development of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors for the treatment of Alzheimer’s disease is the…”
Get full text

Spirocyclic Sulfamides as β‑Secretase 1 (BACE-1) Inhibitors for the Treatment of Alzheimer’s Disease: Utilization of Structure Based Drug Design, WaterMap, and CNS Penetration Studies To Identify Centrally Efficacious Inhibitors by Brodney, Michael A, Barreiro, Gabriela, Ogilvie, Kevin, Hajos-Korcsok, Eva, Murray, John, Vajdos, Felix, Ambroise, Claude, Christoffersen, Curt, Fisher, Katherine, Lanyon, Lorraine, Liu, JianHua, Nolan, Charles E, Withka, Jane M, Borzilleri, Kris A, Efremov, Ivan, Oborski, Christine E, Varghese, Alison, O’Neill, Brian T

“…β-Secretase 1 (BACE-1) is an attractive therapeutic target for the treatment and prevention of Alzheimer’s disease (AD). Herein, we describe the discovery of a…”
Get full text

6-Amino-4-(pyrimidin-4-yl)pyridones: Novel glycogen synthase kinase-3β inhibitors by Coffman, Karen, Brodney, Michael, Cook, James, Lanyon, Lorraine, Pandit, Jayvardhan, Sakya, Subas, Schachter, Joel, Tseng-Lovering, Elaine, Wessel, Matthew

“…The synthesis and structure–activity relationships for a novel series of 6-amino-4-(pyrimidin-4-yl)pyridones derived from a high throughput screening hit are…”
Get full text

P1‐106: Inhibition of Bace2 Affects Melanosome Ultrastructure and Causes of Hypopigmentation by Nolan, Charles E., Karanian, David, Chang, Cheng, Lanyon, Lorraine F., Houle, Christopher, Pandher, Karamjeet, Boucher, Germaine, Hales, Katherine, Gonzales, Cathleen, Ambroise, Claude, Doran, Shawn, Bales, Kelly R., Brodney, Michael

Get full text

A novel LXRα- or RX-independent mechanism for increasing brain APOE levels by Sylvain, Emily, Ramaswamy, Gayathri, Beyna, Mercedes, Duerr, James, Lanyon, Lorraine, LaChapelle, Erik, Pettersson, Martin, Steppan, Claire, Bales, Kelly

Get full text

P4–335: A novel LXRα‐ or RX‐independent mechanism for increasing brain APOE levels by Sylvain, Emily, Ramaswamy, Gayathri, Beyna, Mercedes, Duerr, James, Lanyon, Lorraine, LaChapelle, Erik, Pettersson, Martin, Steppan, Claire, Bales, Kelly

Get full text

P3‐313: Using single‐point pharmacokinetic/pharmacodynamic (PK/PD) analyses to support early discovery of inhibitors of β‐site APP cleaving enzyme 1 (BACE1) by Lu, Yasong, Liu, Jianhua, Nelson, Frederick, Ambroise, Claude, Fisher, Katherine, Hajos-Korcsok, Eva, Noell, Stephen, Nolan, Charles E., Oborski, Christine E., Lanyon, Lorraine F., Christoffersen, Curt, Hannah, Divine, Efremov, Ivan, Helal, Chris, Brodney, Michael A., O'Neill, Brian T.

Get full text

Significant reduction of brain and CSF amyloid-β in mice following acute administration of a brain-penetrant BACE1 inhibitor by Hajos-Korcsok, Eva, Nolan, Charles, Oborski, Christine, Lanyon, Lorraine, Liston, Dane, Ambroise, Claude, Fisher, Katherine, Noell, Stephen, Christoffersen, Curt, Grimwood, Sarah, Hannah, Divine, Bian, Feng, Liu, Jianhua, Nelson, Frederick, Lu, Yasong, Coffey, Heather, Ogilvie, Kevin, Coffman, Karen, Efremov, Ivan, Helal, Christopher, Brodney, Michael, O'Neill, Brian

Get full text

β-secretase inhibitors for treatment of Alzheimer's disease by O'Neill, Brian T, Brodney, Michael A, Ambroise, Claude, Borzilleri, Kris, Coffman, Karen, Efremov, Ivan, Hajos-Korcsok, Eva, Helal, Christopher, Kauffman, Gregory, Lanyon, Lorraine, Liston, Dane, JianHua Liu, Lu, Yasong, Martinez-Alsina, Luis, Murray, John, Nelson, Frederick R, Noell, Stephen, Nolan, Charles, Oborski, Christine, Ogilvie, Kevin, Tuttle, Jamison, Vajdos, Felix, Withka, Jane

Get full text

P3‐282: β‐secretase inhibitors for treatment of Alzheimer's disease by O'Neill, Brian T., Brodney, Michael A., Ambroise, Claude, Borzilleri, Kris, Coffman, Karen, Efremov, Ivan, Hajos-Korcsok, Eva, Helal, Christopher, Kauffman, Gregory, Lanyon, Lorraine, Liston, Dane, JianHua Liu, Lu, Yasong, Martinez-Alsina, Luis, Murray, John, Nelson, Frederick R., Noell, Stephen, Nolan, Charles, Oborski, Christine, Ogilvie, Kevin, Tuttle, Jamison, Vajdos, Felix, Withka, Jane

Get full text

P3‐315: Significant reduction of brain and CSF amyloid‐β in mice following acute administration of a brain‐penetrant BACE1 inhibitor by Hajos-Korcsok, Eva, Nolan, Charles, Oborski, Christine, Lanyon, Lorraine, Liston, Dane, Ambroise, Claude, Fisher, Katherine, Noell, Stephen, Christoffersen, Curt, Grimwood, Sarah, Hannah, Divine, Bian, Feng, Liu, Jianhua, Nelson, Frederick, Lu, Yasong, Coffey, Heather, Ogilvie, Kevin, Coffman, Karen, Efremov, Ivan, Helal, Christopher, Brodney, Michael, O'Neill, Brian

Get full text