Search Results - "Lantz, Melissa K"

Pilot Plant Preparation of an αvβ3 Integrin Antagonist. Part 1. Process Research and Development of a (S)-β-Amino Acid Ester Intermediate:  Synthesis via a Scalable, Diastereoselective Imino-Reformatsky Reaction by Clark, Jerry D, Weisenburger, Gerald A, Anderson, D. Keith, Colson, Pierre-Jean, Edney, Albert D, Gallagher, Donald J, Kleine, H. Peter, Knable, Carl M, Lantz, Melissa K, Moore, Christine M. V, Murphy, James B, Rogers, Thomas E, Ruminski, Peter G, Shah, Ajit S, Storer, Neil, Wise, Bruce E

“…Described are four process research investigations directed toward discerning a scalable, enantioselective method for preparing (S)-β-amino acid ester 3, a key…”
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R-isomers of Arg-Gly-Asp (RGD) mimics as potent αvβ3 inhibitors by NAGARAJAN, Srinivasan R, DEVADAS, Balekudru, LANTZ, Melissa K, JUN ZHU, GREEN, Nawasa F, RUSSELL, Mark A, LANDIS, Bryan H, MILLER, Lawrence M, MEYER, Debra M, DUFFIN, Tiffany D, ENGLEMAN, V. Wayne, FINN, Mary B, MALECHA, James W, FREEMAN, Sandra K, GRIGGS, David W, WILLIAMS, Melanie L, NICKOLS, Maureen A, PEGG, Jodi A, SHANNON, Kristen E, STEININGER, Christina, WESTLIN, Marisa M, NICKOLS, G. Alan, KEENE, Jeffery L, LU, Hwang-Fun, RUMINSKI, Peter G, RICO, Joseph G, ROGERS, Thomas E, MARRUFO, Laura D, COLLINS, Joe T, KLEINE, H. Peter

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Pilot-Plant Preparation of an αvβ3 Integrin Antagonist. Part 3. Process Research and Development of a Diisopropylcarbodiimide and Catalytic 1-Hydroxybenzotriazole Peptide Coupling by Clark, Jerry D, Anderson, D. Keith, Banaszak, David V, Brown, Derek B, Czyzewski, Ann M, Edeny, Albert D, Forouzi, Puneh S, Gallagher, Donald J, Iskos, V. H, Kleine, H. Peter, Knable, Carl M, Lantz, Melissa K, Lapack, Mark A, Moore, Christine M. V, Muellner, Frank W, Murphy, James B, Orihuela, Carlos A, Pietz, Mark A, Rogers, Thomas E, Ruminski, Peter G, Santhanam, Harish K, Schilke, Tobin C, Shah, Ajit S, Sheikh, Ahmad Y, Weisenburger, Gerald A, Wise, Bruce E

“…Studies directed toward the process research, development, and scale-up preparation of the potential αvβ3 integrin antagonist 1 are described. A convergent…”
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Pilot-Plant Preparation of an α v β 3 Integrin Antagonist. Part 3. Process Research and Development of a Diisopropylcarbodiimide and Catalytic 1-Hydroxybenzotriazole Peptide Coupling by Clark, Jerry D., Anderson, D. Keith, Banaszak, David V., Brown, Derek B., Czyzewski, Ann M., Edeny, Albert D., Forouzi, Puneh S., Gallagher, Donald J., Iskos, V. H., Kleine, H. Peter, Knable, Carl M., Lantz, Melissa K., Lapack, Mark A., Moore, Christine M. V., Muellner, Frank W., Murphy, James B., Orihuela, Carlos A., Pietz, Mark A., Rogers, Thomas E., Ruminski, Peter G., Santhanam, Harish K., Schilke, Tobin C., Shah, Ajit S., Sheikh, Ahmad Y., Weisenburger, Gerald A., Wise, Bruce E.

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R-isomers of Arg-Gly-Asp (RGD) mimics as potent alphavbeta3 inhibitors by Nagarajan, Srinivasan R, Devadas, Balekudru, Malecha, James W, Lu, Hwang-Fun, Ruminski, Peter G, Rico, Joseph G, Rogers, Thomas E, Marrufo, Laura D, Collins, Joe T, Kleine, H Peter, Lantz, Melissa K, Zhu, Jun, Green, Nawasa F, Russell, Mark A, Landis, Bryan H, Miller, Lawrence M, Meyer, Debra M, Duffin, Tiffany D, Engleman, V Wayne, Finn, Mary B, Freeman, Sandra K, Griggs, David W, Williams, Melanie L, Nickols, Maureen A, Pegg, Jodi A, Shannon, Kristen E, Steininger, Christina, Westlin, Marisa M, Nickols, G Alan, Keene, Jeffery L

“…The integrin alpha(v)beta(3), vitronectin receptor, is expressed in a number of cell types and has been shown to mediate adhesion of osteoclasts to bone…”
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R-Isomers of Arg-Gly-Asp (RGD) mimics as potent α vβ 3 inhibitors by Nagarajan, Srinivasan R., Devadas, Balekudru, Malecha, James W., Lu, Hwang-Fun, Ruminski, Peter G., Rico, Joseph G., Rogers, Thomas E., Marrufo, Laura D., Collins, Joe T., Kleine, H. Peter, Lantz, Melissa K., Zhu, Jun, Green, Nawasa F., Russell, Mark A., Landis, Bryan H., Miller, Lawrence M., Meyer, Debra M., Duffin, Tiffany D., Engleman, V. Wayne, Finn, Mary B., Freeman, Sandra K., Griggs, David W., Williams, Melanie L., Nickols, Maureen A., Pegg, Jodi A., Shannon, Kristen E., Steininger, Christina, Westlin, Marisa M., Nickols, G. Alan, Keene, Jeffery L.

“…The integrin α vβ 3, vitronectin receptor, is expressed in a number of cell types and has been shown to mediate adhesion of osteoclasts to bone matrix,…”
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Pilot Plant Preparation of an α v β 3 Integrin Antagonist. Part 1. Process Research and Development of a ( S )-β-Amino Acid Ester Intermediate:  Synthesis via a Scalable, Diastereoselective Imino-Reformatsky Reaction by Clark, Jerry D., Weisenburger, Gerald A., Anderson, D. Keith, Colson, Pierre-Jean, Edney, Albert D., Gallagher, Donald J., Kleine, H. Peter, Knable, Carl M., Lantz, Melissa K., Moore, Christine M. V., Murphy, James B., Rogers, Thomas E., Ruminski, Peter G., Shah, Ajit S., Storer, Neil, Wise, Bruce E.

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