Search Results - "Lantry, Laura E"

In Vitro and in Vivo Metabolism of Lu-AMBA, a GRP-Receptor Binding Compound, and the Synthesis and Characterization of Its Metabolites by Linder, Karen E, Metcalfe, Edmund, Arunachalam, Thangavel, Chen, Jianqing, Eaton, Stephen M, Feng, Weiwei, Fan, Hong, Raju, Natarajan, Cagnolini, Aldo, Lantry, Laura E, Nunn, Adrian D, Swenson, Rolf E

“…The metabolism of 177Lu-AMBA (AMBA = DO3A-CH2CO-G-(4-aminobenzoyl)-QWAVGHLM-NH2), a radiotherapeutic compound in clinical development that binds to GRP and NMB…”
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Automated synthesis, characterization and biological evaluation of [(68)Ga]Ga-AMBA, and the synthesis and characterization of (nat)Ga-AMBA and [(67)Ga]Ga-AMBA by Cagnolini, Aldo, Chen, Jianqing, Ramos, Kimberly, Skedzielewski, Tina Marie, Lantry, Laura E, Nunn, Adrian D, Swenson, Rolf E, Linder, Karen E

“…Ga-AMBA (Ga-DO3A-CH(2)CO-G-[4-aminobenzoyl]-QWAVGHLM-NH(2)) is a bombesin-like agonist with high affinity for gastrin releasing peptide receptors (GRP-R)…”
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In vitro binding evaluation of ¹⁷⁷Lu-AMBA, a novel ¹⁷⁷Lu-labeled GRP-R agonist for systemic radiotherapy in human tissues by Thomas, Regi, Chen, Jianqing, Roudier, Martine M, Vessella, Robert L, Lantry, Laura E, Nunn, Adrian D

“…Members of the gastrin-releasing peptide (GRP) family and its analogs bombesin (BBN) have been implicated in the biology of several human cancers including…”
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A germ-line p53 mutation accelerates pulmonary tumorigenesis: p53-independent efficacy of chemopreventive agents green tea or dexamethasone/myo-inositol and chemotherapeutic agents taxol or adriamycin by Zhang, Z, Liu, Q, Lantry, L E, Wang, Y, Kelloff, G J, Anderson, M W, Wiseman, R W, Lubet, R A, You, M

“…Recent evidence indicates that individuals with a p53 germ-line mutation (Li-Fraumeni syndrome) have a 50% risk of developing lung cancer by age 60. In this…”
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Farnesyltransferase inhibitors are potent lung cancer chemopreventive agents in A/J mice with a dominant-negative p53 and/or heterozygous deletion of Ink4a/Arf by ZHONGQIU ZHANG, YIAN WANG, LANTRY, Laura E, KASTENS, Elizabeth, GONGJIE LIU, HAMILTON, Andrew D, SEBTI, Said M, LUBET, Ronald A, MING YOU

“…Mutations in the Kras2 gene are seen in both human and mouse lung adenocarcinomas. The protein product (p21ras) encoded by the Kras2 gene must be…”
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p53 Transgenic mice are highly susceptible to 1, 2-dimethylhydrazine-induced uterine sarcomas by ZHONGQIU ZHANG, JIE LI, LANTRY, Laura E, YIAN WANG, WISEMAN, Roger W, LUBET, Ronald A, MING YOU

“…p53 Transgenic mice were crossed with C57BL/6J mice to investigate whether a germ-line mutation in the p53 gene predisposes for tumorigenesis in mice…”
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Effect of farnesyltransferase inhibitor FTI-276 on established lung adenomas from A/J mice induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by Lantry, Laura E., Zhang, Zhongqiu, Yao, Rusheng, Crist, Keith A., Wang, Yian, Ohkanda, Junko, Hamilton, Andrew D., Sebti, Said M., lubet, Ronald A., You, Ming

“…The Ras protein undergoes a series of post-translational modifications at the C-terminal CAAX motif, which culminates with the anchoring of p21 Ras to the…”
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CHEMOPREVENTIVE EFFICACY OF PROMISING FARNESYLTRANSFERASE INHIBITORS by Lantry, Laura E., Zhang, Zhongqiu, Crist, Keith A., Wang, Yian, Hara, Mitsunobu, Zeeck, Axel, Lubet, Ronald A., You, Ming

“…The studies presented were designed to test the efficacy of farnesyltransferase inhibitors (FTIs) as potential chemopreventive compounds in the mouse lung…”
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Cytotoxicity of tocopherols and their quinones in drug‐sensitive and multidrug‐resistant leukemia cells by Cornwell, David G., Jones, Kenneth H., Jiang, Zongcheng, Lantry, Laura E., Southwell‐Keely, Peter, Kohar, Indrajati, Thornton, Donald E.

“…Cytotoxicities of tocopherols (α‐T, γ‐T, δ‐T), their para (α‐TQ, γ‐TQ, δ‐TQ)‐and ortho (Tocored)‐quinone oxidation products, the synthetic quinone analog of…”
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sup 177^Lu-AMBA Biodistribution, Radiotherapeutic Efficacy, Imaging, and Autoradiography in Prostate Cancer Models with Low GRP-R Expression by Maddalena, Mary Ellen, Fox, Jaclyn, Chen, Jianqing, Feng, Weiwei, Cagnolini, Aldo, Linder, Karen E, Tweedle, Michael F, Nunn, Adrian D, Lantry, Laura E

“…^sup 177^Lu-DO3A-CH^sub 2^CO-G-4-aminobenzoyl-Q-W-A-V-G-H-L-M-NH^sub 2^ (^sup 177^Lu-AMBA) is a radiolabeled bombesin derivative that is bound and internalized…”
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177 Lu-AMBA Biodistribution, Radiotherapeutic Efficacy, Imaging, and Autoradiography in Prostate Cancer Models with Low GRP-R Expression by Maddalena, Mary Ellen, Fox, Jaclyn, Chen, Jianqing, Feng, Weiwei, Cagnolini, Aldo, Linder, Karen E., Tweedle, Michael F., Nunn, Adrian D., Lantry, Laura E.

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177Lu-AMBA Biodistribution, Radiotherapeutic Efficacy, Imaging, and Autoradiography in Prostate Cancer Models with Low GRP-R Expression by Maddalena, Mary Ellen, Fox, Jaclyn, Chen, Jianqing, Feng, Weiwei, Cagnolini, Aldo, Linder, Karen E, Tweedle, Michael F, Nunn, Adrian D, Lantry, Laura E

“…(177)Lu-DO3A-CH(2)CO-G-4-aminobenzoyl-Q-W-A-V-G-H-L-M-NH(2) ((177)Lu-AMBA) is a radiolabeled bombesin derivative that is bound and internalized by cells…”
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Automated synthesis, characterization and biological evaluation of [ 68Ga]Ga-AMBA, and the synthesis and characterization of natGa-AMBA and [ 67Ga]Ga-AMBA by Cagnolini, Aldo, Chen, Jianqing, Ramos, Kimberly, Marie Skedzielewski, Tina, Lantry, Laura E., Nunn, Adrian D., Swenson, Rolf E., Linder, Karen E.

“…Ga-AMBA (Ga-DO3A-CH 2CO-G-[4-aminobenzoyl]-QWAVGHLM-NH 2) is a bombesin-like agonist with high affinity for gastrin releasing peptide receptors (GRP-R)…”
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sup 177^Lu-AMBA: Synthesis and Characterization of a Selective ^sup 177^Lu-Labeled GRP-R Agonist for Systemic Radiotherapy of Prostate Cancer by Lantry, Laura E, Cappelletti, Enrico, Maddalena, Mary Ellen, Fox, Jaclyn S

“…Gastrin-releasing peptide receptors (GRP-R) are upregulated in many cancers, including prostate, breast, and lung. We describe a new radiolabeled bombesin…”
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177Lu-AMBA: Synthesis and Characterization of a Selective 177Lu-Labeled GRP-R Agonist for Systemic Radiotherapy of Prostate Cancer by Lantry, Laura E, Cappelletti, Enrico, Maddalena, Mary Ellen, Fox, Jaclyn S, Feng, Weiwei, Chen, Jianqing, Thomas, Regi, Eaton, Stephen M, Bogdan, Nancy J, Arunachalam, Thangavel, Reubi, Jean Claude, Raju, Natarajan, Metcalfe, Edmund C, Lattuada, Luciano, Linder, Karen E, Swenson, Rolf E, Tweedle, Michael F, Nunn, Adrian D

“…Gastrin-releasing peptide receptors (GRP-R) are upregulated in many cancers, including prostate, breast, and lung. We describe a new radiolabeled bombesin…”
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5-Aza-2'-deoxycytidine is chemopreventive in a 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone-induced primary mouse lung tumor model by LANTRY, L. E, ZHANG, Z, CRIST, K. A, WANG, Y, KELLOFF, G. J, LUBET, R. A, YOU, M

“…Carcinogenesis is a multistep process in which many alterations in both genetic and epigenetic controls lead to a growth advantage for neoplastic cells…”
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Chemopreventive effect of perillyl alcohol on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced tumorigenesis in (C3H/HeJ X A/J)F1 mouse lung by Lantry, Laura E., Zhang, Zhongqiu, Gao, Feng, Crist, Keith A., Wang, Yian, Kelloff, Gary J., Lubet, Ronald A., You, Ming

“…This study was designed to test the chemopreventive potential of perillyl alcohol, an inhibitor of farnesyltransferase, in a mouse lung tumor bioassay…”
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5-Aza-2'-deoxycyctidine is chemopreventive in a 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung tumor model by Lantry, Laura E, Zhang, Zhongqiu, Crist, Keith A, Wang, Yian

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Ranibizumab, a mAb against VEGF-A for the potential treatment of age-related macular degeneration and other ocular complications by Lantry, Laura E

“…Genentech Inc and Novartis Ophthalmics AG have developed and launched the humanized anti-VEGF antibody fragment ranibizumab, a 48-kDa humanized antibody…”
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Cdkn2a encodes functional variation of p16INK4a but not p14ARF, which confers selection in mouse lung tumorigenesis by Herzog, Christopher R., Noh, Seong, Lantry, Laura E., Guan, Kuan-Liang, You, Ming

“…The cyclin‐dependent kinase inhibitor 2a (Cdkn2a) locus encodes two distinct tumor suppressors, p16INK4a and p19ARF, whose functions interrelate in the…”
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