The influence of simultaneous integrated boost, hypofractionation and oncoplastic surgery on cosmetic outcome and PROMs after breast conserving therapy

The influence of simultaneous integrated boost, hypofractionation and oncoplastic surgery on cosmetic outcome and PROMs after breast conserving therapy

Abstract Introduction We retrospectively investigated the possible influence of a simultaneous integrated boost (SIB), hypofractionation and oncoplastic surgery on cosmetic outcome in 125 patients with stage I–II breast cancer treated with breast conserving therapy (BCT). Patients and methods The bo...

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Bibliographic Details
Published in:European journal of surgical oncology Vol. 41; no. 10; pp. 1411 - 1416
Main Authors: Lansu, J.T.P, Essers, M, Voogd, A.C, Luiten, E.J.T, Buijs, C, Groenendaal, N, Poortmans, P.M.H
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01-10-2015
Subjects:
Aged
Breast conserving therapy
Breast Neoplasms - therapy
Case-Control Studies
Chemotherapy, Adjuvant
Cohort Studies
Cosmetic results
Dose Hypofractionation
Female
Hematology, Oncology and Palliative Medicine
Humans
Hypofractionation
Mammaplasty - methods
Mastectomy, Segmental - methods
Middle Aged
Oncoplastic surgery
Patient Outcome Assessment
Quality of Life
Quality of life (QOL)
Radiotherapy, Adjuvant - methods
Radiotherapy, Conformal - methods
Retrospective Studies
Simultaneous integrated boost (SIB)
Surgery
Surveys and Questionnaires
Treatment Outcome
Hypofractionation
Quality of life (QOL)
Breast conserving therapy
Simultaneous integrated boost (SIB)
Cosmetic results
Oncoplastic surgery
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Summary:Abstract Introduction We retrospectively investigated the possible influence of a simultaneous integrated boost (SIB), hypofractionation and oncoplastic surgery on cosmetic outcome in 125 patients with stage I–II breast cancer treated with breast conserving therapy (BCT). Patients and methods The boost was given sequentially (55%) or by SIB (45%); fractionation was conventional (83%) or hypofractionated (17%); the surgical technique was a conventional lumpectomy (74%) or an oncoplastic technique (26%). We compared cosmetic results subjectively using a questionnaire independently completed by the patient and by the physician and objectively with the BCCT.core software. Independent-samples T-tests were used to compare outcome in different groups. Patients also completed the EORTC QLQ C30 and BR23. Results Univariate analyses indicated no significant differences of the cosmetic results (P ≤ 0.05) for the type of boost or fractionation. However, the conventional lumpectomy group scored significantly better than the oncoplastic group in the BCCT.core evaluation, without a significant difference in the subjective cosmetic evaluation. Quality of life outcome was in favour of SIB, hypofractionation and conventional surgery. Conclusion Our study indicates that the current RT techniques seem to be safe for cosmetic outcome and quality of life. Further investigation is needed to verify the possible negative influence of oncoplastic surgery on the cosmetic outcome and the quality of life as this technique is especially indicated for patients with an unfavourable tumour/breast volume ratio.
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ISSN:0748-7983
1532-2157
DOI:10.1016/j.ejso.2015.07.011