Search Results - "Lansing, C."

Controlled tetra-Fc sialylation of IVIg results in a drug candidate with consistent enhanced anti-inflammatory activity by Washburn, Nathaniel, Schwab, Inessa, Ortiz, Daniel, Bhatnagar, Naveen, Lansing, Jonathan C., Medeiros, Amy, Tyler, Steven, Mekala, Divya, Cochran, Edward, Sarvaiya, Hetal, Garofalo, Kevin, Meccariello, Robin, Meador, James W., Rutitzky, Laura, Schultes, Birgit C., Ling, Leona, Avery, William, Nimmerjahn, Falk, Manning, Anthony M., Kaundinya, Ganesh V., Bosques, Carlos J.

“…Despite the beneficial therapeutic effects of intravenous immunoglobulin (IVIg) in inflammatory diseases, consistent therapeutic efficacy and potency remain…”
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Fast and accurate fitting of relaxation dispersion data using the flexible software package GLOVE by Sugase, Kenji, Konuma, Tsuyoshi, Lansing, Jonathan C., Wright, Peter E.

“…Relaxation dispersion spectroscopy is one of the most widely used techniques for the analysis of protein dynamics. To obtain a detailed understanding of the…”
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Hydrogen Production Catalyzed by Bidirectional, Biomimetic Models of the [FeFe]-Hydrogenase Active Site by Lansing, James C, Camara, James M, Gray, Danielle E, Rauchfuss, Thomas B

“…Active site mimics of [FeFe]-hydrogenase are shown to be bidirectional catalysts, producing H2 upon treatment with protons and reducing equivalents. This…”
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Ferrous Carbonyl Dithiolates as Precursors to FeFe, FeCo, and FeMn Carbonyl Dithiolates by Carroll, Maria E, Chen, Jinzhu, Gray, Danielle E, Lansing, James C, Rauchfuss, Thomas B, Schilter, David, Volkers, Phillip I, Wilson, Scott R

“…Reported are complexes of the formula Fe­(dithiolate)­(CO)2(diphos) and their use to prepare homo- and heterobimetallic dithiolato derivatives. The starting…”
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Defining the Role of Active-Site Loop Fluctuations in Dihydrofolate Reductase Catalysis by McElheny, Dan, Schnell, Jason R., Lansing, Jonathan C., Dyson, H. Jane, Wright, Peter E., Petsko, Gregory A.

“…Dynamic processes are implicit in the catalytic function of all enzymes. To obtain insights into the relationship between the dynamics and thermodynamics of…”
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High-resolution physicochemical characterization of different intravenous immunoglobulin products by Washburn, Nathaniel, Meccariello, Robin, Hu, Shaohui, Hains, Maurice, Bhatnagar, Naveen, Sarvaiya, Hetal, Kapoor, Bulbul, Schaeck, John, Pino, Ignacio, Manning, Anthony, Lansing, Jonathan C, Bosques, Carlos J

“…Intravenous immunoglobulin (IVIg) is a complex mixture drug comprising diverse immunoglobulins and non-IgG proteins purified from the plasma of thousands of…”
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Tailoring Relaxation Dispersion Experiments for Fast-Associating Protein Complexes by Sugase, Kenji, Lansing, Jonathan C, Dyson, H. Jane, Wright, Peter E

“…NMR relaxation dispersion spectroscopy is a powerful technique to elucidate the mechanism of protein−protein binding reactions. However, it is difficult to…”
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High-Frequency Dynamic Nuclear Polarization in MAS Spectra of Membrane and Soluble Proteins by Rosay, Melanie, Lansing, Jonathan C, Haddad, Kristin C, Bachovchin, William W, Herzfeld, Judith, Temkin, Richard J, Griffin, Robert G

“…One of the principal promises of solid-state NMR (SSNMR) magic angle spinning (MAS) experiments has been the possibility of determining the structures of…”
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Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events by Viswanathan, Karthik, Guerrini, Marco, Buhse, Lucinda, Torri, Giangiacomo, Venkataraman, Ganesh, Al-Hakim, Ali, Robinson, Luke, Bisio, Antonella, Shriver, Zachary, Naggi, Annamaria, Capila, Ishan, Zhang, Zhenqing, Fraser, Blair, Langer, Robert, Sasisekharan, Ram, Woodcock, Janet, Casu, Benito, Linhardt, Robert J, Beccati, Daniela, Nasr, Moheb, Guglieri, Sara, Gunay, Nur Sibel, Lansing, Jonathan C

“…Recently, certain lots of heparin have been associated with an acute, rapid onset of serious side effects indicative of an allergic-type reaction. To identify…”
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Contaminated Heparin Associated with Adverse Clinical Events and Activation of the Contact System by Kishimoto, Takashi Kei, Viswanathan, Karthik, Ganguly, Tanmoy, Elankumaran, Subbiah, Smith, Sean, Pelzer, Kevin, Lansing, Jonathan C, Sriranganathan, Nammalwar, Zhao, Ganlin, Galcheva-Gargova, Zoya, Al-Hakim, Ali, Bailey, Gregory Scott, Fraser, Blair, Roy, Sucharita, Rogers-Cotrone, Thomas, Buhse, Lucinda, Whary, Mark, Fox, James, Nasr, Moheb, Dal Pan, Gerald J, Shriver, Zachary, Langer, Robert S, Venkataraman, Ganesh, Austen, K. Frank, Woodcock, Janet, Sasisekharan, Ram

“…Recently the heparin supply in 12 countries was found to be contaminated with a substance that caused hypotension and, in some cases, death. The contaminant…”
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Biobased Methacrylic Acid via Selective Catalytic Decarboxylation of Itaconic Acid by Lansing, James C, Murray, Rex E, Moser, Bryan R

“…We report a biobased route to methacrylic acid via selective decarboxylation of itaconic acid utilizing catalytic ruthenium carbonyl propionate in an aqueous…”
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Elucidating the interplay between IgG-Fc valency and FcγR activation for the design of immune complex inhibitors by Ortiz, Daniel F, Lansing, Jonathan C, Rutitzky, Laura, Kurtagic, Elma, Prod'homme, Thomas, Choudhury, Amit, Washburn, Nathaniel, Bhatnagar, Naveen, Beneduce, Christopher, Holte, Kimberly, Prenovitz, Robert, Child, Matthew, Killough, Jason, Tyler, Steven, Brown, Julia, Nguyen, Stephanie, Schwab, Inessa, Hains, Maurice, Meccariello, Robin, Markowitz, Lynn, Wang, Jing, Zouaoui, Radouane, Simpson, Allison, Schultes, Birgit, Capila, Ishan, Ling, Leona, Nimmerjahn, Falk, Manning, Anthony M, Bosques, Carlos J

“…Autoantibody immune complex (IC) activation of Fcγ receptors (FcγRs) is a common pathogenic hallmark of multiple autoimmune diseases. Given that the IC…”
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Heat‐ and light‐induced thiol‐ene oligomerization of soybean oil‐based polymercaptan by Bantchev, Grigor B., Vermillion, Karl E., Lansing, James C., Biresaw, Girma

“…ABSTRACT Polymercaptanized soybean oil (PMSO), the product of a thiol‐ene reaction between soybean oil and hydrogen sulfide, is a material of interest as a…”
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Chromophore Distortions in the Bacteriorhodopsin Photocycle:  Evolution of the H−C14−C15−H Dihedral Angle Measured by Solid-State NMR by Lansing, Jonathan C, Hohwy, Morten, Jaroniec, Christopher P, Creemers, A. F. L, Lugtenburg, Johan, Herzfeld, Judith, Griffin, Robert G

“…In recent years, structural information about bacteriorhodopsin has grown substantially with the publication of several crystal structures. However, precise…”
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Parameters Governing Ruthenium Sawhorse-Based Decarboxylation of Oleic Acid by Doll, Kenneth M, Bantchev, Grigor B, Walter, Erin L, Murray, Rex E, Appell, Michael, Lansing, James C, Moser, Bryan R

“…Ruthenium-catalyzed decarboxylation of 9-cis-octadecenoic is a path to produce biobased olefins. Here, a mechanistic study of this reaction was undertaken…”
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Early and Late M Intermediates in the Bacteriorhodopsin Photocycle:  A Solid-State NMR Study by Hu, Jingui G, Sun, Boqin Q, Bizounok, Marina, Hatcher, Mary E, Lansing, Jonathan C, Raap, Jan, Verdegem, Peter J. E, Lugtenburg, Johan, Griffin, Robert G, Herzfeld, Judith

“…To enforce vectorial proton transport in bacteriorhodopsin (bR), it is necessary that there be a change in molecular structure between deprotonation and…”
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Solid-State NMR Investigation of the Buried X−Proline Peptide Bonds of Bacteriorhodopsin by Lansing, Jonathan C, Hu, Jingui G, Belenky, Marina, Griffin, Robert G, Herzfeld, Judith

“…The role of proline residues in the photocycle of bacteriorhodopsin (bR) is addressed using solid-state NMR. 13C and 15N chemical shifts from X−Pro peptide…”
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Vancomycin-resistant Enterococci may obtain nutritional support by scavenging carbohydrate fragments generated during mucin degradation by the anaerobic microbiota of the colon by Pultz, Nicole J, Hoskins, Lansing C, Donskey, Curtis J

“…Vancomycin-resistant Enterococcus (VRE) is an important nosocomial pathogen that colonizes the intestinal tract. The substrates that provide nutritional…”
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Melodic, rhythmic, and timbral perception of adult cochlear implant users by Gfeller, K, Lansing, C R

“…The purpose of this pilot study was to investigate adult Ineraid and Nucleus cochlear implant (CI) users' perceptual accuracy for melodic and rhythmic…”
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Development of Glatopa® (Glatiramer Acetate): The First FDA-Approved Generic Disease-Modifying Therapy for Relapsing Forms of Multiple Sclerosis by Bell, Christine, Anderson, James, Ganguly, Tanmoy, Prescott, James, Capila, Ishan, Lansing, Jonathan C., Sachleben, Richard, Iyer, Mani, Fier, Ian, Roach, James, Storey, Kristina, Miller, Paul, Hall, Steven, Kantor, Daniel, Greenberg, Benjamin M., Nair, Kavita, Glajch, Joseph

“…The multiple sclerosis (MS) treatment landscape in the United States has changed dramatically over the past decade. While many disease-modifying therapies…”
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