Search Results - "Lanoix, Joel"
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OpenCustomDB: Integration of Unannotated Open Reading Frames and Genetic Variants to Generate More Comprehensive Customized Protein Databases
Published in Journal of proteome research (05-05-2023)“…Proteomic diversity in biological samples can be characterized by mass spectrometry (MS)-based proteomics using customized protein databases generated from…”
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Comparison of the MHC I Immunopeptidome Repertoire of B‐Cell Lymphoblasts Using Two Isolation Methods
Published in Proteomics (Weinheim) (01-06-2018)“…Significant technological advances in both affinity chromatography and mass spectrometry have facilitated the identification of peptides associated with the…”
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Breast cancer immunopeptidomes contain numerous shared tumor antigens
Published in The Journal of clinical investigation (01-01-2024)“…Hormone receptor-positive breast cancer (HR+) is immunologically cold and has not benefited from advances in immunotherapy. In contrast, subsets of…”
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Autophagy degrades immunogenic endogenous retroelements induced by 5-azacytidine in acute myeloid leukemia
Published in Leukemia (01-05-2024)“…The hypomethylating agent 5-azacytidine (AZA) is the first-line treatment for AML patients unfit for intensive chemotherapy. The effect of AZA results in part…”
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Induced pluripotent stem cells display a distinct set of MHC I-associated peptides shared by human cancers
Published in Cell reports (Cambridge) (16-08-2022)“…Previous reports showed that mouse vaccination with pluripotent stem cells (PSCs) induces durable anti-tumor immune responses via T cell recognition of some…”
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H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone
Published in Cancer discovery (01-12-2020)“…Glycine 34-to-tryptophan (G34W) substitutions in H3.3 arise in approximately 90% of giant cell tumor of bone (GCT). Here, we show H3.3 G34W is necessary for…”
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Transposable elements regulate thymus development and function
Published in eLife (18-04-2024)“…Transposable elements (TEs) are repetitive sequences representing ~45% of the human and mouse genomes and are highly expressed by medullary thymic epithelial…”
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Cdc42 and Rac1 activity is reduced in human pheochromocytoma and correlates with FARP1 and ARHGEF1 expression
Published in Endocrine-related cancer (01-04-2016)“…Abstract Among small GTPases from the Rho family, Cdc42, Rac, and Rho are well known to mediate a large variety of cellular processes linked with cancer…”
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Proteomic analysis of the transitional endoplasmic reticulum in hepatocellular carcinoma: An organelle perspective on cancer
Published in Biochimica et biophysica acta (01-09-2010)“…The transitional endoplasmic reticulum (tER) is composed of both rough and smooth ER membranes and thus participates in functions attributed to both these two…”
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Most non-canonical proteins uniquely populate the proteome or immunopeptidome
Published in Cell reports (Cambridge) (09-03-2021)“…Combining RNA sequencing, ribosome profiling, and mass spectrometry, we elucidate the contribution of non-canonical translation to the proteome and major…”
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Atypical acute myeloid leukemia-specific transcripts generate shared and immunogenic MHC class-I-associated epitopes
Published in Immunity (Cambridge, Mass.) (13-04-2021)“…Acute myeloid leukemia (AML) has not benefited from innovative immunotherapies, mainly because of the lack of actionable immune targets. Using an original…”
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Taking organelles apart, putting them back together and creating new ones: Lessons from the endoplasmic reticulum
Published in Progress in histochemistry and cytochemistry (01-06-2011)“…The endoplasmic reticulum (ER) is a highly dynamic organelle. It is composed of four subcompartments including nuclear envelope (NE), rough ER (rER), smooth ER…”
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Immunogenicity of Non-Mutated Ovarian Cancer-Specific Antigens
Published in Current oncology (Toronto) (01-06-2024)“…Epithelial ovarian cancer (EOC) has not significantly benefited from advances in immunotherapy, mainly because of the lack of well-defined actionable antigen…”
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MhcVizPipe: A Quality Control Software for Rapid Assessment of Small- to Large-Scale Immunopeptidome Datasets
Published in Molecular & cellular proteomics (01-01-2022)“…MS-based immunopeptidomics is maturing into an automatized and high-throughput technology, producing small- to large-scale datasets of clinically relevant…”
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Dysfunction of calcium-regulated exocytosis at a single-cell level causes catecholamine hypersecretion in patients with pheochromocytoma
Published in Cancer letters (01-09-2022)“…Neuroendocrine tumors constitute a heterogeneous group of tumors arising from hormone-secreting cells and are generally associated with a dysfunction of…”
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Isolation of Human Prostatic Epithelial Plasma Membranes for Proteomics Using Mirror Image Tissue Banking of Radical Prostatectomy Specimens
Published in Clinical cancer research (15-07-2006)“…Purpose: To isolate human prostatic epithelial plasma membranes for the identification of cell surface proteins in the therapeutic targeting of cancer cells…”
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Extending the Comprehensiveness of Immunopeptidome Analyses Using Isobaric Peptide Labeling
Published in Analytical chemistry (Washington) (07-07-2020)“…Defining the repertoire of peptides presented by the major histocompatibility complex class I (MHC I) is a key step toward the identification of relevant…”
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Immunopeptidomic Analyses of Colorectal Cancers With and Without Microsatellite Instability
Published in Molecular & cellular proteomics (01-05-2022)“…Colorectal cancer is the second leading cause of cancer death worldwide, and the incidence of this disease is expected to increase as global socioeconomic…”
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Transposable elements regulate thymus development and function
Published in eLife (18-04-2024)“…Transposable elements (TEs) are repetitive sequences representing ~45% of the human and mouse genomes and are highly expressed by medullary thymic epithelial…”
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Sorting of Golgi Resident Proteins into Different Subpopulations of COPI Vesicles: A Role for ArfGAP1
Published in The Journal of cell biology (24-12-2001)“…We present evidence for two subpopulations of coatomer protein I vesicles, both containing high amounts of Golgi resident proteins but only minor amounts of…”
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