Application of the total reflection X-ray fluorescence method to the elemental analysis of brain tumors of different types and grades of malignancy

The process of carcinogenesis may influence normal biochemical reactions leading to alterations in the elemental composition of the tissue. Total reflection X-ray fluorescence analysis (TXRF) was applied to the elemental analysis of different brain tumors. The following elements were present in all...

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Bibliographic Details
Published in:	Spectrochimica acta. Part B: Atomic spectroscopy Vol. 101; pp. 98 - 105
Main Authors:	Lankosz, M.W., Grzelak, M., Ostachowicz, B., Wandzilak, A., Szczerbowska-Boruchowska, M., Wrobel, P., Radwanska, E., Adamek, D.
Format:	Journal Article
Language:	English
Published:	Elsevier B.V 01-11-2014
Subjects:	Alterations Biochemistry Brain Brain tumors Concentration (composition) Grade of malignancy Iron Reflection Total reflection X-ray fluorescence Trace elements Tumors X-ray fluorescence analysis Trace elements Total reflection X-ray fluorescence Grade of malignancy Brain tumors
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Summary:	The process of carcinogenesis may influence normal biochemical reactions leading to alterations in the elemental composition of the tissue. Total reflection X-ray fluorescence analysis (TXRF) was applied to the elemental analysis of different brain tumors. The following elements were present in all the neoplastic tissues analyzed: K, Ca, Fe, Cu, Zn and Rb. The results of the analysis showed that the elemental composition of a relatively small fragment of tissue represents satisfactorily the biochemical “signature” of a cancer. On the basis of the element concentrations determined, it was possible to differentiate between some types of brain tumors. •Elemental composition represents the biochemical signature of brain cancer.•The element levels differentiate some types of brain tumors.•TXRF spectrometry is a useful tool for elemental trace analysis of brain cancer.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0584-8547 1873-3565
DOI:	10.1016/j.sab.2014.07.019