Search Results - "Lankelma, Jacqueline M."

Critically ill patients demonstrate large interpersonal variation in intestinal microbiota dysregulation: a pilot study by Lankelma, Jacqueline M., van Vught, Lonneke A., Belzer, Clara, Schultz, Marcus J., van der Poll, Tom, de Vos, Willem M., Wiersinga, W. Joost

“…Purpose The intestinal microbiota has emerged as a virtual organ with essential functions in human physiology. Antibiotic-induced disruption of the microbiota…”
Get full text

Effect of antibiotic gut microbiota disruption on LPS-induced acute lung inflammation by Jacobs, Max C, Lankelma, Jacqueline M, Wolff, Nora S, Hugenholtz, Floor, de Vos, Alex F, van der Poll, Tom, Wiersinga, W Joost

“…An increasing body of evidence is indicating that the gut microbiota modulates pulmonary inflammatory responses. This so-called gut-lung axis might be of…”
Get full text

Comparison of host immune responses to LPS in human using an immune profiling panel, in vivo endotoxemia versus ex vivo stimulation by Tawfik, Dina M., Lankelma, Jacqueline M., Vachot, Laurence, Cerrato, Elisabeth, Pachot, Alexandre, Wiersinga, W. Joost, Textoris, Julien

“…Patients that suffer from sepsis exhibit an early hyper-inflammatory immune response which can lead to organ failure and death. In our study, we assessed the…”
Get full text

The gut microbiota as a modulator of innate immunity during melioidosis by Lankelma, Jacqueline M, Birnie, Emma, Weehuizen, Tassili A F, Scicluna, Brendon P, Belzer, Clara, Houtkooper, Riekelt H, Roelofs, Joris J T H, de Vos, Alex F, van der Poll, Tom, Budding, Andries E, Wiersinga, W Joost

“…Melioidosis, caused by the Gram-negative bacterium Burkholderia pseudomallei, is an emerging cause of pneumonia-derived sepsis in the tropics. The gut…”
Get full text

Integrative Transkingdom Analysis of the Gut Microbiome in Antibiotic Perturbation and Critical Illness by Haak, Bastiaan W, Argelaguet, Ricard, Kinsella, Cormac M, Kullberg, Robert F J, Lankelma, Jacqueline M, Deijs, Martin, Klein, Michelle, Jebbink, Maarten F, Hugenholtz, Floor, Kostidis, Sarantos, Giera, Martin, Hakvoort, Theodorus B M, de Jonge, Wouter J, Schultz, Marcus J, van Gool, Tom, van der Poll, Tom, de Vos, Willem M, van der Hoek, Lia M, Wiersinga, W Joost

“…Bacterial microbiota play a critical role in mediating local and systemic immunity, and shifts in these microbial communities have been linked to impaired…”
Get full text

Triggering Receptor Expressed on Myeloid Cells (TREM)-2 Impairs Host Defense in Experimental Melioidosis by Weehuizen, Tassili A F, Hommes, Tijmen J, Lankelma, Jacqueline M, de Jong, Hanna K, Roelofs, Joris J T H, de Vos, Alex F, Colonna, Marco, van der Poll, Tom, Wiersinga, W Joost

“…Triggering receptor expressed on myeloid cells (TREM) -1 and TREM-2 are key regulators of the inflammatory response that are involved in the clearance of…”
Get full text

The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia by Schuijt, Tim J, Lankelma, Jacqueline M, Scicluna, Brendon P, de Sousa e Melo, Felipe, Roelofs, Joris J T H, de Boer, J Daan, Hoogendijk, Arjan J, de Beer, Regina, de Vos, Alex, Belzer, Clara, de Vos, Willem M, van der Poll, Tom, Wiersinga, W Joost

“…Pneumonia accounts for more deaths than any other infectious disease worldwide. The intestinal microbiota supports local mucosal immunity and is increasingly…”
Get more information

Long-term impact of oral vancomycin, ciprofloxacin and metronidazole on the gut microbiota in healthy humans by Haak, Bastiaan W, Lankelma, Jacqueline M, Hugenholtz, Floor, Belzer, Clara, de Vos, Willem M, Wiersinga, W Joost

“…Abstract Objectives The impact of combination antibiotic therapy on the composition of the intestinal microbiota remains ill-defined. We aimed to assess the…”
Get full text

Antibiotic-induced gut microbiota disruption during human endotoxemia: a randomised controlled study by Lankelma, Jacqueline M, Cranendonk, Duncan R, Belzer, Clara, de Vos, Alex F, de Vos, Willem M, van der Poll, Tom, Wiersinga, W Joost

“…The gut microbiota is essential for the development of the intestinal immune system. Animal models have suggested that the gut microbiota also acts as a major…”
Get more information

Role of Peptidylarginine Deiminase 4 in Neutrophil Extracellular Trap Formation and Host Defense during Klebsiella pneumoniae- Induced Pneumonia-Derived Sepsis by Claushuis, Theodora A M, van der Donk, Lieve E H, Luitse, Anna L, van Veen, Henk A, van der Wel, Nicole N, van Vught, Lonneke A, Roelofs, Joris J T H, de Boer, Onno J, Lankelma, Jacqueline M, Boon, Louis, de Vos, Alex F, van 't Veer, Cornelis, van der Poll, Tom

“…Peptidylarginine deiminase 4 (PAD4) catalyzes citrullination of histones, an important step for neutrophil extracellular trap (NET) formation. We aimed to…”
Get full text

Gut microbiota disruption in critically ill patients: Discussion on “Critically ill patients demonstrate large interpersonal variation of intestinal microbiota dysregulation: a pilot study” by Iapichino, Gaetano, Lankelma, Jacqueline M., Joost Wiersinga, W.

Get full text

Vitek ® 2 MICs as first-line phenotypic screening method for carbapenemase-producing Pseudomonas aeruginosa by Sieswerda, Elske, Bosch, Thijs, Lankelma, Jacqueline M, Schouls, Leo M, Dijk, Karin van

“…To define sensitivity and specificity of Vitek 2 MICs as phenotypic screening method for carbapenemase-producing . We determined Vitek 2 MICs of…”
Get full text

Cathepsin L, target in cancer treatment? by Lankelma, Jacqueline M., Voorend, Daniëlle M., Barwari, Temo, Koetsveld, Joris, Van der Spek, Anne H., De Porto, Alexander P.N.A., Van Rooijen, Geeske, Van Noorden, Cornelis J.F.

“…Cathepsin L, a cysteine protease, is considered to be a potential therapeutic target in cancer treatment. Proteases are involved in the development and…”
Get full text

Role of Toll-Like Receptor 5 (TLR5) in Experimental Melioidosis by Birnie, Emma, Weehuizen, Tassili A F, Lankelma, Jacqueline M, de Jong, Hanna K, Koh, Gavin C K W, van Lieshout, Miriam H P, Roelofs, Joris J T H, Budding, Andries E, de Vos, Alex F, van der Poll, Tom, Wiersinga, W Joost

“…The Gram-negative intracellular pathogen is the causative agent of melioidosis, an important cause of sepsis in Southeast Asia. Recognition of…”
Get full text

Therapeutic Administration of a Monoclonal Anti-Il-1β Antibody Protects Against Experimental Melioidosis by Weehuizen, Tassili A F, Lankelma, Jacqueline M, De Jong, Hanna K, De Boer, Onno J, Roelofs, Joris J. T H, Day, Nicholas P, Gram, Hermann, De Vos, Alex F, Wiersinga, W Joost

“…BACKGROUND:Melioidosis, caused by the gram-negative bacterium Burkholderia pseudomallei, is a common cause of community-acquired sepsis in Southeast Asia and…”
Get full text

Rapid DNA vaccination against Burkholderia pseudomallei flagellin by tattoo or intranasal application by Lankelma, Jacqueline M., Wagemakers, Alex, Birnie, Emma, Haak, Bastiaan W., Trentelman, Jos J. A., Weehuizen, Tassili A. F., Ersöz, Jasmin, Roelofs, Joris J. T. H., Hovius, Joppe W., Wiersinga, W. Joost, Bins, Adriaan D.

“…Melioidosis is a severe infectious disease with a high mortality that is endemic in South-East Asia and Northern Australia. The causative pathogen,…”
Get full text

Antibiotic-Induced Gut Microbiota Disruption Decreases TNF-α Release by Mononuclear Cells in Healthy Adults by Lankelma, Jacqueline M, Belzer, Clara, Hoogendijk, Arie J, de Vos, Alex F, de Vos, Willem M, van der Poll, Tom, Wiersinga, W Joost

“…Broad-spectrum antibiotics disrupt the intestinal microbiota. The microbiota is essential for physiological processes, such as the development of the gut…”
Get full text

Integrative Transkingdom Analysis of the Gut Microbiome in Antibiotic Perturbation and Critical Illness by Haak, Bastiaan W., Argelaguet, Ricard, Kinsella, Cormac M., Kullberg, Robert F. J., Lankelma, Jacqueline M., Deijs, Martin, Klein, Michelle, Jebbink, Maarten F., Hugenholtz, Floor, Kostidis, Sarantos, Giera, Martin, Hakvoort, Theodorus B. M., de Jonge, Wouter J., Schultz, Marcus J., van Gool, Tom, van der Poll, Tom, de Vos, Willem M., van der Hoek, Lia M., Wiersinga, W. Joost

“…Bacterial microbiota play a critical role in mediating local and systemic immunity, and shifts in these microbial communities have been linked to impaired…”
Get full text

Gut microbiota disruption in critically ill patients by Iapichino, Gaetano, Lankelma, Jacqueline M, Joost Wiersinga, W

Get full text

Triggering Receptor Expressed on Myeloid Cells by Lankelma, Jacqueline M, van der Poll, Tom, de Vos, Alex F, Colonna, Marco, Wiersinga, W. Joost, Hommes, Tijmen J, Weehuizen, Tassili A. F, Roelofs, Joris. J.T.H, de Jong, Hanna K

“…Background Triggering receptor expressed on myeloid cells (TREM) -1 and TREM-2 are key regulators of the inflammatory response that are involved in the…”
Get full text