Search Results - "Lanke, Kjerstin H.W."

Itraconazole Inhibits Enterovirus Replication by Targeting the Oxysterol-Binding Protein by Strating, Jeroen R.P.M., van der Linden, Lonneke, Albulescu, Lucian, Bigay, Joëlle, Arita, Minetaro, Delang, Leen, Leyssen, Pieter, van der Schaar, Hilde M., Lanke, Kjerstin H.W., Thibaut, Hendrik Jan, Ulferts, Rachel, Drin, Guillaume, Schlinck, Nina, Wubbolts, Richard W., Sever, Navdar, Head, Sarah A., Liu, Jun O., Beachy, Philip A., De Matteis, Maria A., Shair, Matthew D., Olkkonen, Vesa M., Neyts, Johan, van Kuppeveld, Frank J.M.

“…Itraconazole (ITZ) is a well-known antifungal agent that also has anticancer activity. In this study, we identify ITZ as a broad-spectrum inhibitor of…”
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Cytokine and Chemokine Production by Human Pancreatic Islets Upon Enterovirus Infection by SCHULTE, Barbara M, LANKE, Kjerstin H. W, GALAMA, Jochem M, ADEMA, Gosse J, VAN KUPPEVELD, Frank J. M, PIGANELLI, Jon D, KERS-REBEL, Esther D, BOTTINO, Rita, TRUCCO, Massimo, HUIJBENS, Richard J. F, RADSTAKE, Timothy R. D. J, ENGELSE, Marten A, DE KONING, Eelco J. P

“…Enteroviruses of the human enterovirus B species (HEV-Bs) (e.g., coxsackie B viruses [CVBs] and echoviruses) have been implicated as environmental factors that…”
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mengovirus leader protein blocks interferon-α/β gene transcription and inhibits activation of interferon regulatory factor 3 by Hato, Stanleyson V, Ricour, Celine, Schulte, Barbara M, Lanke, Kjerstin H.W, de Bruijni, Mike, Zoll, Jan, Melchers, Willem J.G, Michiels, Thomas, van Kuppeveld, Frank J.M

“…Viral infection of mammalian cells triggers the synthesis and secretion of type I interferons (i.e. IFN-α/β), which induce the transcription of genes that…”
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Phagocytosis of Enterovirus-Infected Pancreatic β-Cells Triggers Innate Immune Responses in Human Dendritic Cells by SCHULTE, Barbara M, KRAMER, Matthijs, VAN KUPPEVELD, Frank J. M, ANSEMS, Marleen, LANKER, Kjerstin H. W, VAN DOREMALEN, Neeltje, PIGANELLI, Jon D, BOTTINO, Rita, TRUCCO, Massimo, GALAMA, Jochem M. D, ADEMA, Gosse J

“…Type 1 diabetes is a chronic endocrine disorder in which enteroviruses, such as coxsackie B viruses and echoviruses, are possible environmental factors that…”
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Detection of enterovirus RNA in peripheral blood mononuclear cells of type 1 diabetic patients beyond the stage of acute infection by Schulte, Barbara M, Bakkers, Judith, Lanke, Kjerstin H W, Melchers, Willem J G, Westerlaken, Ciska, Allebes, Wil, Aanstoot, Henk-Jan, Bruining, G Jan, Adema, Gosse J, Van Kuppeveld, Frank J M, Galama, Jochem M D

“…Previous studies have shown that enteroviral RNA can be detected in blood at the onset of type 1 diabetes (T1D). The infection may play a role in triggering…”
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Differential Membrane Association Properties and Regulation of Class I and Class II Arfs by Duijsings, Daniël, Lanke, Kjerstin H.W, van Dooren, Sander H.J, van Dommelen, Michiel M.T, Wetzels, Roy, de Mattia, Fabrizio, Wessels, Els, van Kuppeveld, Frank J.M

“…ADP-ribosylation factor (Arf) proteins are small guanosine triphosphatases (GTPases) that act as major regulators of intracellular vesicular trafficking and…”
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Single dose primaquine for clearance of Plasmodium falciparum gametocytes in children with uncomplicated malaria in Uganda: a randomised, controlled, double-blind, dose-ranging trial by Eziefula, Alice C, Dr, Bousema, Teun, PhD, Yeung, Shunmay, PhD, Kamya, Moses, Prof, Owaraganise, Asiphas, MBChB, Gabagaya, Grace, MBChB, Bradley, John, PhD, Grignard, Lynn, PhD, Lanke, Kjerstin H W, BSc, Wanzira, Humphrey, MSc, Mpimbaza, Arthur, MMed, Nsobya, Samuel, PhD, White, Nicholas J, Prof, Webb, Emily L, PhD, Staedke, Sarah G, PhD, Drakeley, Chris, Prof

“…Summary Background Primaquine is the only available drug that clears mature Plasmodium falciparum gametocytes in infected human hosts, thereby preventing…”
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Efficacy and Safety of the Mosquitocidal Drug Ivermectin to Prevent Malaria Transmission After Treatment: A Double-Blind, Randomized, Clinical Trial by Lin Ouédraogo, André, Bastiaens, Guido J. H., Tiono, Alfred B., Guelbéogo, Wamdaogo M., Kobylinski, Kevin C., Ouédraogo, Alphonse, Barry, Aïssata, Bougouma, Edith C., Nebie, Issa, San Ouattara, Maurice, Lanke, Kjerstin H. W., Fleckenstein, Lawrence, Sauerwein, Robert W., Slater, Hannah C., Churcher, Thomas S., Sirima, Sodiomon B., Drakeley, Chris, Bousema, Teun

“…Background. Artemisinin combination therapy effectively clears asexual malaria parasites and immature gametocytes but does not prevent posttreatment malaria…”
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The relevance and applicability of oocyst prevalence as a read-out for mosquito feeding assays by Stone, Will J. R., Eldering, Maarten, van Gemert, Geert-Jan, Lanke, Kjerstin H. W., Grignard, Lynn, van de Vegte-Bolmer, Marga G., Siebelink-Stoter, Rianne, Graumans, Wouter, Roeffen, Will F. G., Drakeley, Chris J., Sauerwein, Robert W., Bousema, Teun

“…Mosquito feeding assays are important in evaluations of malaria transmission-reducing interventions. The proportion of mosquitoes with midgut oocysts is…”
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A Novel, Broad-Spectrum Inhibitor of Enterovirus Replication That Targets Host Cell Factor Phosphatidylinositol 4-Kinase IIIβ by van der Schaar, Hilde M, Leyssen, Pieter, Thibaut, Hendrik J, de Palma, Armando, van der Linden, Lonneke, Lanke, Kjerstin H W, Lacroix, Céline, Verbeken, Erik, Conrath, Katja, Macleod, Angus M, Mitchell, Dale R, Palmer, Nicholas J, van de Poël, Hervé, Andrews, Martin, Neyts, Johan, van Kuppeveld, Frank J M

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Coxsackievirus mutants that can bypass host factor PI4KIIIβ and the need for high levels of PI4P lipids for replication by van der Schaar, Hilde M, van der Linden, Lonneke, Lanke, Kjerstin H W, Strating, Jeroen R P M, Pürstinger, Gerhard, de Vries, Erik, de Haan, Cornelis A M, Neyts, Johan, van Kuppeveld, Frank J M

“…RNA viruses can rapidly mutate and acquire resistance to drugs that directly target viral enzymes, which poses serious problems in a clinical context…”
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Quantification of female and male Plasmodium falciparum gametocytes by reverse transcriptase quantitative PCR by Schneider, Petra, Reece, Sarah E., van Schaijk, Ben C.L., Bousema, Teun, Lanke, Kjerstin H.W., Meaden, Cora S.J., Gadalla, Amal, Ranford-Cartwright, Lisa C., Babiker, Hamza A.

“…Sex-specific RT-qPCRs quantify densities as low as 0.04 female and 0.3 male gametocytes/PCR reaction (corresponding to 0.3 female and 1.8 male gametocytes/(l…”
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Safety of single low-dose primaquine in glucose-6-phosphate dehydrogenase deficient falciparum-infected African males: Two open-label, randomized, safety trials by Bastiaens, Guido J H, Tiono, Alfred B, Okebe, Joseph, Pett, Helmi E, Coulibaly, Sam A, Gonçalves, Bronner P, Affara, Muna, Ouédraogo, Alphonse, Bougouma, Edith C, Sanou, Guillaume S, Nébié, Issa, Bradley, John, Lanke, Kjerstin H W, Niemi, Mikko, Sirima, Sodiomon B, d'Alessandro, Umberto, Bousema, Teun, Drakeley, Chris

“…Primaquine (PQ) actively clears mature Plasmodium falciparum gametocytes but in glucose-6-phosphate dehydrogenase deficient (G6PDd) individuals can cause…”
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GBF1, a Guanine Nucleotide Exchange Factor for Arf, Is Crucial for Coxsackievirus B3 RNA Replication by LANKE, Kjerstin H. W, VAN DER SCHAAR, Hilde M, BELOV, George A, QIAN FENG, DUIJSINGS, Daniël, JACKSON, Catherine L, EHRENFELD, Ellie, VAN KUPPEVELD, Frank J. M

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Selective Serotonin Reuptake Inhibitor Fluoxetine Inhibits Replication of Human Enteroviruses B and D by Targeting Viral Protein 2C by ULFERTS, Rachel, DER LINDEN, Lonneke Van, JAN THIBAUT, Hendrik, LANKE, Kjerstin H. W, LEYSSEN, Pieter, COUTARD, Bruno, DE PALMA, Armando M, CANARD, Bruno, NEYTS, Johan, KUPPEVELD, Frank J. M. Van

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A Scalable Assessment of Plasmodium falciparum Transmission in the Standard Membrane-Feeding Assay, Using Transgenic Parasites Expressing Green Fluorescent Protein-Luciferase by Stone, Will J. R., Churcher, Thomas S., Graumans, Wouter, van Gemert, Geert-Jan, Vos, Martijn W., Lanke, Kjerstin H. W., van de Vegte-Bolmer, Marga G., Siebelink-Stoter, Rianne, Dechering, Koen J., Vaughan, Ashley M., Camargo, Nelly, Kappe, Stefan H. I., Sauerwein, Robert W., Bousema, Teun

“…Background. The development of drugs and vaccines to reduce malaria transmission is an important part of eradication plans. The transmission-reducing activity…”
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A Viral Protein that Blocks Arf1-Mediated COP-I Assembly by Inhibiting the Guanine Nucleotide Exchange Factor GBF1 by Wessels, Els, Duijsings, Daniël, Niu, Ting-Kuang, Neumann, Steffi, Oorschot, Viola M., de Lange, Frank, Lanke, Kjerstin H.W., Klumperman, Judith, Henke, Andreas, Jackson, Catherine L., Melchers, Willem J.G., van Kuppeveld, Frank J.M.

“…Many viruses modify cellular processes for their own benefit. The enterovirus 3A protein inhibits endoplasmic reticulum (ER)-to-Golgi transport, a function…”
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Bead-based assays to simultaneously detect multiple human inherited blood disorders associated with malaria by Grignard, Lynn, Mair, Catherine, Curry, Jonathan, Mahey, Laleta, Bastiaens, Guide J H, Tiono, Alfred B, Okebe, Joseph, Coulibaly, Sam A, Gonçalves, Bronner P, Affara, Muna, Ouédraogo, Alphonse, Bougouma, Edith C, Sanou, Guillaume S, Nébié, Issa, Lanke, Kjerstin H W, Sirima, Sodiomon B, d'Alessandro, Umberto, Clark, Taane G, Campino, Susana, Bousema, Teun, Drakeley, Chris

“…Glucose-6-phosphate dehydrogenase deficiency (G6PDd), haemoglobin C (HbC) and S (HbS) are inherited blood disorders (IBD) common in populations in malaria…”
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Differential Effects of the Putative GBF1 Inhibitors Golgicide A and AG1478 on Enterovirus Replication by van der Linden, Lonneke, van der Schaar, Hilde M, Lanke, Kjerstin H W, Neyts, Johan, van Kuppeveld, Frank J M

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Application of a cell-based protease assay for testing inhibitors of picornavirus 3C proteases by van der Linden, Lonneke, Ulferts, Rachel, Nabuurs, Sander B., Kusov, Yuri, Liu, Hong, George, Shyla, Lacroix, Céline, Goris, Nesya, Lefebvre, David, Lanke, Kjerstin H.W., De Clercq, Kris, Hilgenfeld, Rolf, Neyts, Johan, van Kuppeveld, Frank J.M.

“…•We have modified a cell-based assay and applied it to many picornavirus proteases.•The assay is amenable for high-throughput screening.•Application of the…”
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