Search Results - "Languino, Lucia R"

CD45 Phosphatase Inhibits STAT3 Transcription Factor Activity in Myeloid Cells and Promotes Tumor-Associated Macrophage Differentiation by Kumar, Vinit, Cheng, Pingyan, Condamine, Thomas, Mony, Sridevi, Languino, Lucia R., McCaffrey, Judith C., Hockstein, Neil, Guarino, Michael, Masters, Gregory, Penman, Emily, Denstman, Fred, Xu, Xiaowei, Altieri, Dario C., Du, Hong, Yan, Cong, Gabrilovich, Dmitry I.

“…Recruitment of monocytic myeloid-derived suppressor cells (MDSCs) and differentiation of tumor-associated macrophages (TAMs) are the major factors contributing…”
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PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion by Caino, M. Cecilia, Jagadish C. Ghosh, Young Chan Chae, Valentina Vaira, Dayana B. Rivadeneira, Alice Faversani, Paolo Rampini, Andrew V. Kossenkov, Katherine M. Aird, Rugang Zhang, Marie R. Webster, Ashani T. Weeraratna, Silvano Bosari, Lucia R. Languino, Dario C. Altieri

“…Molecular therapies are hallmarks of “personalized” medicine, but how tumors adapt to these agents is not well-understood. Here we show that small-molecule…”
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Identification of monocyte-like precursors of granulocytes in cancer as a mechanism for accumulation of PMN-MDSCs by Mastio, Jérôme, Condamine, Thomas, Dominguez, George, Kossenkov, Andrew V, Donthireddy, Laxminarasimha, Veglia, Filippo, Lin, Cindy, Wang, Fang, Fu, Shuyu, Zhou, Jie, Viatour, Patrick, Lavilla-Alonso, Sergio, Polo, Alexander T, Tcyganov, Evgenii N, Mulligan, Jr, Charles, Nam, Brian, Bennett, Joseph, Masters, Gregory, Guarino, Michael, Kumar, Amit, Nefedova, Yulia, Vonderheide, Robert H, Languino, Lucia R, Abrams, Scott I, Gabrilovich, Dmitry I

“…We have identified a precursor that differentiates into granulocytes in vitro and in vivo yet belongs to the monocytic lineage. We have termed these cells…”
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The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis by Seo, Jae Ho, Rivadeneira, Dayana B, Caino, M Cecilia, Chae, Young Chan, Speicher, David W, Tang, Hsin-Yao, Vaira, Valentina, Bosari, Silvano, Palleschi, Alessandro, Rampini, Paolo, Kossenkov, Andrew V, Languino, Lucia R, Altieri, Dario C

“…Mitochondria must buffer the risk of proteotoxic stress to preserve bioenergetics, but the role of these mechanisms in disease is poorly understood. Using a…”
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A neuronal network of mitochondrial dynamics regulates metastasis by Caino, M. Cecilia, Seo, Jae Ho, Aguinaldo, Angeline, Wait, Eric, Bryant, Kelly G., Kossenkov, Andrew V., Hayden, James E., Vaira, Valentina, Morotti, Annamaria, Ferrero, Stefano, Bosari, Silvano, Gabrilovich, Dmitry I., Languino, Lucia R., Cohen, Andrew R., Altieri, Dario C.

“…The role of mitochondria in cancer is controversial. Using a genome-wide shRNA screen, we now show that tumours reprogram a network of mitochondrial dynamics…”
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Small Extracellular Vesicle Regulation of Mitochondrial Dynamics Reprograms a Hypoxic Tumor Microenvironment by Bertolini, Irene, Ghosh, Jagadish C., Kossenkov, Andrew V., Mulugu, Sudheer, Krishn, Shiv Ram, Vaira, Valentina, Qin, Jun, Plow, Edward F., Languino, Lucia R., Altieri, Dario C.

“…The crosstalk between tumor cells and the adjacent normal epithelium contributes to cancer progression, but its regulators have remained elusive. Here, we show…”
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Survivin promotes oxidative phosphorylation, subcellular mitochondrial repositioning, and tumor cell invasion by Rivadeneira, Dayana B, Caino, M Cecilia, Seo, Jae Ho, Angelin, Alessia, Wallace, Douglas C, Languino, Lucia R, Altieri, Dario C

“…Survivin promotes cell division and suppresses apoptosis in many human cancers, and increased abundance correlates with metastasis and poor prognosis. We…”
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Control of Tumor Bioenergetics and Survival Stress Signaling by Mitochondrial HSP90s by Chae, Young Chan, Caino, M. Cecilia, Lisanti, Sofia, Ghosh, Jagadish C., Dohi, Takehiko, Danial, Nika N., Villanueva, Jessie, Ferrero, Stefano, Vaira, Valentina, Santambrogio, Luigi, Bosari, Silvano, Languino, Lucia R., Herlyn, Meenhard, Altieri, Dario C.

“…Tumors successfully adapt to constantly changing intra- and extracellular environments, but the wirings of this process are still largely elusive. Here, we…”
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MFF Regulation of Mitochondrial Cell Death Is a Therapeutic Target in Cancer by Seo, Jae Ho, Chae, Young Chan, Kossenkov, Andrew V, Lee, Yu Geon, Tang, Hsin-Yao, Agarwal, Ekta, Gabrilovich, Dmitry I, Languino, Lucia R, Speicher, David W, Shastrula, Prashanth K, Storaci, Alessandra Maria, Ferrero, Stefano, Gaudioso, Gabriella, Caroli, Manuela, Tosi, Davide, Giroda, Massimo, Vaira, Valentina, Rebecca, Vito W, Herlyn, Meenhard, Xiao, Min, Fingerman, Dylan, Martorella, Alessandra, Skordalakes, Emmanuel, Altieri, Dario C

“…The regulators of mitochondrial cell death in cancer have remained elusive, hampering the development of new therapies. Here, we showed that protein isoforms…”
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Small extracellular vesicle-mediated ITGB6 siRNA delivery downregulates the αVβ6 integrin and inhibits adhesion and migration of recipient prostate cancer cells by Krishn, Shiv Ram, Garcia, Vaughn, Naranjo, Nicole M., Quaglia, Fabio, Shields, Christopher D., Harris, Maisha A., Kossenkov, Andrew V., Liu, Qin, Corey, Eva, Altieri, Dario C., Languino, Lucia R.

“…The αVβ6 integrin, an epithelial-specific cell surface receptor absent in normal prostate and expressed during prostate cancer (PrCa) progression, is a…”
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Role of Kindlin 2 in prostate cancer by Bialkowska, Katarzyna, El Khalki, Lamyae, Rana, Priyanka S., Wang, Wei, Lindner, Daniel J., Parker, Yvonne, Languino, Lucia R., Altieri, Dario C., Pluskota, Elzbieta, Sossey-Alaoui, Khalid, Plow, Edward F.

“…Kindlin-2 is a cytoskeletal adapter protein that is present in many different cell types. By virtue of its interaction with multiple binding partners,…”
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Myc-mediated transcriptional regulation of the mitochondrial chaperone TRAP1 controls primary and metastatic tumor growth by Agarwal, Ekta, Altman, Brian J., Seo, Jae Ho, Ghosh, Jagadish C., Kossenkov, Andrew V., Tang, Hsin-Yao, Krishn, Shiv Ram, Languino, Lucia R., Gabrilovich, Dmitry I., Speicher, David W., Dang, Chi V., Altieri, Dario C.

“…The role of mitochondria in cancer continues to be debated, and whether exploitation of mitochondrial functions is a general hallmark of malignancy or a tumor-…”
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Myc Regulation of a Mitochondrial Trafficking Network Mediates Tumor Cell Invasion and Metastasis by Agarwal, Ekta, Altman, Brian J., Ho Seo, Jae, Bertolini, Irene, Ghosh, Jagadish C., Kaur, Amanpreet, Kossenkov, Andrew V., Languino, Lucia R., Gabrilovich, Dmitry I., Speicher, David W., Dang, Chi V., Altieri, Dario C.

“…The Myc gene is a universal oncogene that promotes aggressive cancer, but its role in metastasis has remained elusive. Here, we show that Myc transcriptionally…”
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Trop-2 inhibits prostate cancer cell adhesion to fibronectin through the β1 integrin-RACK1 axis by Trerotola, Marco, Li, Jing, Alberti, Saverio, Languino, Lucia R.

“…Trop‐2 is a transmembrane glycoprotein upregulated in several human carcinomas, including prostate cancer (PrCa). Trop‐2 has been suggested to regulate…”
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Neuroendocrine gene subsets are uniquely dysregulated in prostate adenocarcinoma by Naranjo, Nicole M, Kennedy, Anne, Testa, Anna, Verrillo, Cecilia E, Altieri, Adrian D, Kean, Rhonda, Hooper, D Craig, Yu, Jindan, Zhao, Jonathan, Abinader, Oliver, Pickles, Maxwell W, Hawkins, Adam, Kelly, William K, Mitra, Ramkrishna, Languino, Lucia R

“…Prostate cancer has heterogeneous growth patterns, and its prognosis is the poorest when it progresses to a neuroendocrine phenotype. Using bioinformatic…”
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Deletion of the Mitochondrial Chaperone TRAP-1 Uncovers Global Reprogramming of Metabolic Networks by Lisanti, Sofia, Tavecchio, Michele, Chae, Young Chan, Liu, Qin, Brice, Angela K., Thakur, Madhukar L., Languino, Lucia R., Altieri, Dario C.

“…Reprogramming of metabolic pathways contributes to human disease, especially cancer, but the regulators of this process are unknown. Here, we have generated a…”
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Integrins in prostate cancer progression by Goel, Hira Lal, Li, Jing, Kogan, Sophia, Languino, Lucia R

“…Integrins, which are transmembrane receptors for extracellular matrix proteins, play a key role in cell survival, proliferation, migration, gene expression,…”
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αvβ6 integrin is required for TGFβ1-mediated matrix metalloproteinase2 expression by Dutta, Anindita, Li, Jing, Fedele, Carmine, Sayeed, Aejaz, Singh, Amrita, Violette, Shelia M, Manes, Thomas D, Languino, Lucia R

“…Transforming growth factor (TGF) β1 activity depends on a complex signalling cascade that controls expression of several genes. Among others, TGFβ1 regulates…”
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Cytoprotective Mitochondrial Chaperone TRAP-1 As a Novel Molecular Target in Localized and Metastatic Prostate Cancer by Leav, Irwin, Plescia, Janet, Goel, Hira Lal, Li, Jing, Jiang, Zhong, Cohen, Ronald J, Languino, Lucia R, Altieri, Dario C

“…Molecular chaperones of the heat shock protein-90 (Hsp90) family promote cell survival, but the molecular requirements of this pathway in tumor progression are…”
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The NOGO receptor NgR2, a novel αVβ3 integrin effector, induces neuroendocrine differentiation in prostate cancer by Quaglia, Fabio, Krishn, Shiv Ram, Sossey-Alaoui, Khalid, Rana, Priyanka Shailendra, Pluskota, Elzbieta, Park, Pyung Hun, Shields, Christopher D., Lin, Stephen, McCue, Peter, Kossenkov, Andrew V., Wang, Yanqing, Goodrich, David W., Ku, Sheng-Yu, Beltran, Himisha, Kelly, William K., Corey, Eva, Klose, Maja, Bandtlow, Christine, Liu, Qin, Altieri, Dario C., Plow, Edward F., Languino, Lucia R.

“…Androgen deprivation therapies aimed to target prostate cancer (PrCa) are only partially successful given the occurrence of neuroendocrine PrCa (NEPrCa), a…”
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