Search Results - "Langston, Rebekah G."

The function of orthologues of the human Parkinson's disease gene LRRK2 across species: implications for disease modelling in preclinical research by Langston, Rebekah G, Rudenko, Iakov N, Cookson, Mark R

“…In the period since LRRK2 (leucine-rich repeat kinase 2) was identified as a causal gene for late-onset autosomal dominant parkinsonism, a great deal of work…”
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The G2385R risk factor for Parkinson's disease enhances CHIP-dependent intracellular degradation of LRRK2 by Rudenko, Iakov N, Kaganovich, Alice, Langston, Rebekah G, Beilina, Aleksandra, Ndukwe, Kelechi, Kumaran, Ravindran, Dillman, Allissa A, Chia, Ruth, Cookson, Mark R

“…Autosomal dominant mutations in ( ) are associated with Parkinson's disease (PD). Most pathogenic mutations result in amino acid substitutions in the central…”
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Correction: Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia by Mamais, Adamantios, Kluss, Jillian H, Bonet-Ponce, Luis, Landeck, Natalie, Langston, Rebekah G, Smith, Nathan, Beilina, Alexandra, Kaganovich, Alice, Ghosh, Manik C, Pellegrini, Laura, Kumaran, Ravindran, Papazoglou, Ioannis, Heaton, George R, Harvey, Kirsten, Bandopadhyay, Rina, Maio, Nunziata, Kim, Changyoun, LaVoie, Matthew J, Gershlick, David C, Cookson, Mark R

“…[This corrects the article DOI: 10.1371/journal.pbio.3001480.]…”
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Use of a Modified STROOP Test to Assess Color Discrimination Deficit in Parkinson's Disease by Langston, Rebekah G, Virmani, Tuhin

“…To objectively measure color vision dysfunction in idiopathic Parkinson's disease (iPD) using an easily administered, essentially free, modified Stroop test…”
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Generation of fourteen isogenic cell lines for Parkinson’s disease-associated leucine-rich repeat kinase (LRRK2) by Beylina, Aleksandra, Langston, Rebekah G., Rosen, Dorien, Reed, Xylena, Cookson, Mark R.

“…Mutations in leucine-rich repeat kinase 2 (LRRK2) are associated with inherited forms of Parkinson’s disease (PD), causing disease by a gain of kinase…”
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Hexokinases link DJ-1 to the PINK1/parkin pathway by Hauser, David N, Mamais, Adamantios, Conti, Melissa M, Primiani, Christopher T, Kumaran, Ravindran, Dillman, Allissa A, Langston, Rebekah G, Beilina, Alexandra, Garcia, Joseph H, Diaz-Ruiz, Alberto, Bernier, Michel, Fiesel, Fabienne C, Hou, Xu, Springer, Wolfdieter, Li, Yan, de Cabo, Rafael, Cookson, Mark R

“…Early onset Parkinson's disease is caused by variants in PINK1, parkin, and DJ-1. PINK1 and parkin operate in pathways that preserve mitochondrial integrity,…”
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Characteristics and career outcomes of Neurosurgery Research and Education Foundation research fellowship recipients by Wilson, Taylor A, Langston, Rebekah G, Wong, Ka Hin, Rodriguez, Analiz

“…The American Association of Neurological Surgeons (AANS) Neurosurgery Research and Education Foundation (NREF) provides ongoing competitive research…”
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Recent trends in NIH funding for top surgeon-scientists by Langston, Rebekah G., Zhao, Edward H., Wong, Ka Hin, Rodriguez, Analiz

“…Concerns regarding the trajectory and long-term sustainability of the surgeon-scientist career path have been widely recognized.1–3 Today there is a lack of…”
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Association of a common genetic variant with Parkinson's disease is mediated by microglia by Langston, Rebekah G, Beilina, Alexandra, Reed, Xylena, Kaganovich, Alice, Singleton, Andrew B, Blauwendraat, Cornelis, Gibbs, J Raphael, Cookson, Mark R

“…Studies of multiple neurodegenerative disorders have identified many genetic variants that are associated with risk of disease throughout a lifetime. For…”
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Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia by Mamais, Adamantios, Kluss, Jillian H, Bonet-Ponce, Luis, Landeck, Natalie, Langston, Rebekah G, Smith, Nathan, Beilina, Alexandra, Kaganovich, Alice, Ghosh, Manik C, Pellegrini, Laura, Kumaran, Ravindran, Papazoglou, Ioannis, Heaton, George R, Bandopadhyay, Rina, Maio, Nunziata, Kim, Changyoun, LaVoie, Matthew J, Gershlick, David C, Cookson, Mark R

“…Mutations in leucine-rich repeat kinase 2 (LRRK2) cause autosomal dominant Parkinson disease (PD), while polymorphic LRRK2 variants are associated with…”
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Coding and Noncoding Variation in LRRK2 and Parkinson's Disease Risk by Lake, Julie, Reed, Xylena, Langston, Rebekah G., Nalls, Mike A., Gan‐Or, Ziv, Cookson, Mark R., Singleton, Andrew B., Blauwendraat, Cornelis, Leonard, Hampton L.

“…Background The leucine‐rich repeat kinase 2 (LRRK2) gene harbors both rare highly damaging missense variants (eg, p.G2019S) and common noncoding variants (eg,…”
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Genetic analysis of amyotrophic lateral sclerosis identifies contributing pathways and cell types by Saez-Atienzar, Sara, Bandres-Ciga, Sara, Langston, Rebekah G, Kim, Jonggeol J, Choi, Shing Wan, Reynolds, Regina H, Abramzon, Yevgeniya, Dewan, Ramita, Ahmed, Sarah, Landers, John E, Chia, Ruth, Ryten, Mina, Cookson, Mark R, Nalls, Michael A, Chiò, Adriano, Traynor, Bryan J

“…Despite the considerable progress in unraveling the genetic causes of amyotrophic lateral sclerosis (ALS), we do not fully understand the molecular mechanisms…”
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Intracranial hematolymphoid malignancies: A case series with molecular characterization by Langston, Rebekah G., Pinckard-Dover, Heather, Guzman, Grace, Wardell, Christopher P., Gokden, Murat, Morris, T.W., Day, J.D., Rodriguez, Analiz

“…Central nervous system (CNS) manifestations of hematologic malignancies are uncommon and often have a poor prognosis. As hematologic neoplasms are typically…”
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Pathways of protein synthesis and degradation in PD pathogenesis by Langston, Rebekah G, Cookson, Mark R

“…Since the discovery of protein aggregates in the brains of individuals with Parkinson's disease (PD) in the early 20th century, the scientific community has…”
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Differences in Stability, Activity and Mutation Effects Between Human and Mouse Leucine-Rich Repeat Kinase 2 by Langston, Rebekah G., Rudenko, Iakov N., Kumaran, Ravindran, Hauser, David N., Kaganovich, Alice, Ponce, Luis Bonet, Mamais, Adamantios, Ndukwe, Kelechi, Dillman, Allissa A., Al-Saif, Amr M., Beilina, Aleksandra, Cookson, Mark R.

“…Mutations in the Leucine-rich repeat kinase 2 ( LRRK2 ) gene have been implicated in the pathogenesis of Parkinson’s disease (PD). Identification of…”
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Evaluating N-benzylgalactonoamidines as putative transition state analogs for β-galactoside hydrolysis by Fan, Qiu-Hua, Striegler, Susanne, Langston, Rebekah G, Barnett, James D

“…Experimental evidence is provided for p-methylbenzyl-D-galactonoamidine to function as a true transition state analog for the enzymatic hydrolysis of…”
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Primary glioblastoma of the cauda equina with molecular and histopathological characterization: Case report by Langston, Rebekah G, Wardell, Christopher P, Palmer, Angela, Scott, Hayden, Gokden, Murat, Pait, T Glenn, Rodriguez, Analiz

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The Polg Mutator Phenotype Does Not Cause Dopaminergic Neurodegeneration in DJ-1-Deficient Mice by Hauser, David N, Primiani, Christopher T, Langston, Rebekah G, Kumaran, Ravindran, Cookson, Mark R

“…Mutations in the DJ-1 gene cause autosomal recessive parkinsonism in humans. Several mouse models of DJ-1 deficiency have been developed, but they do not have…”
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LAG3 is not expressed in human and murine neurons and does not modulate α‐synucleinopathies by Emmenegger, Marc, De Cecco, Elena, Hruska‐Plochan, Marian, Eninger, Timo, Schneider, Matthias M, Barth, Melanie, Tantardini, Elena, de Rossi, Pierre, Bacioglu, Mehtap, Langston, Rebekah G, Kaganovich, Alice, Bengoa‐Vergniory, Nora, Gonzalez‐Guerra, Andrès, Avar, Merve, Heinzer, Daniel, Reimann, Regina, Häsler, Lisa M, Herling, Therese W, Matharu, Naunehal S, Landeck, Natalie, Luk, Kelvin, Melki, Ronald, Kahle, Philipp J, Hornemann, Simone, Knowles, Tuomas P J, Cookson, Mark R, Polymenidou, Magdalini, Jucker, Mathias, Aguzzi, Adriano

“…While the initial pathology of Parkinson’s disease and other α‐synucleinopathies is often confined to circumscribed brain regions, it can spread and…”
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Investigating the Role of a Common Genetic Variant in Parkinson’s Disease Pathogenesis by Langston, Rebekah G

“…Parkinson’s disease (PD) is an age-related neurodegenerative disorder, for which only limited symptomatic treatments are available. Leucine-rich repeat kinase…”
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