Search Results - "Langsch, Angelika"

Comment on Bernard et al. Association between Urinary Metabolites and the Exposure of Intensive Care Newborns to Plasticizers of Medical Devices Used for Their Care Management. Metabolites 2021, 11, 252 by Otter, Rainer, Langsch, Angelika, Harmon, Patrick, Boito, Scott C., Mervart, Jan, Grass, Michael, Sarginson, Nigel J.

“…The recent publication “Association between Urinary Metabolites and the Exposure of Intensive Care Newborns to Plasticizers of Medical Devices Used for Their…”
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Development and characterization of a small-scale bioreactor based on a bioartificial hepatic culture model for predictive pharmacological in vitro screenings by Schmitmeier, Stephanie, Langsch, Angelika, Jasmund, Inka, Bader, Augustinus

“…A vast majority of pharmacons are beset by possible interactions and side effects which have usually been tested in laboratory animals. However, better methods…”
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Interspecies difference in liver-specific functions and biotransformation of testosterone of primary rat, porcine and human hepatocyte in an organotypical sandwich culture by Langsch, Angelika, Giri, Shibashish, Acikgöz, Ali, Jasmund, Inka, Frericks, Bernd, Bader, Augustinus

“…Interspecies difference is an important issue in toxicology research. We compared the potential in vitro metabolism of human, porcine and rat hepatocytes over…”
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Longterm stability of phase I and phase II enzymes of porcine liver cells in flat membrane bioreactors by Langsch, Angelika, Bader, Augustinus

“…Recently, researchers have focused on the use of bioartificial liver devices to support patients with fulminant hepatic failure. Our team developed a…”
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Cultivation of Primary Porcine Hepatocytes in an OXY-HFB for Use as a Bioartificial Liver Device by Jasmund, Inka, Langsch, Angelika, Simmoteit, Robert, Bader, Augustinus

“…Bioreactors being developed for bioartificial liver devices vary greatly in their construction. Until now, primary liver cells were cultivated either in…”
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Language Development of Young Children Is Not Linked to Phthalate Exposure by Otter, Rainer, Langsch, Angelika, Swaen, Gerard

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Systematic comparison of the male reproductive tract in fetal and adult Wistar rats exposed to DBP and DINP in utero during the masculinisation programming window by van den Driesche, Sander, Shoker, Serena, Inglis, Fiona, Palermo, Christine, Langsch, Angelika, Otter, Rainer

“…•DINP exposure in the MPW (e15.5–18.5) does not result in effects known for DBP.•DINP exposure in the MPW has no effect ADG on e21.5.•Leydig cell aggregates on…”
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Structure‐Performance Guided Design of Sustainable Plasticizers from Biorenewable Feedstocks by Plass, Carmen, Adebar, Niklas, Hiessl, Robert, Kleber, Joscha, Grimm, Axel, Langsch, Angelika, Otter, Rainer, Liese, Andreas, Gröger, Harald

“…The search for more sustainable solutions for plastics production, moving away from petrochemical feedstocks as today's major raw material basis, is a research…”
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Front Cover: Structure‐Performance Guided Design of Sustainable Plasticizers from Biorenewable Feedstocks (Eur. J. Org. Chem. 45/2021) by Plass, Carmen, Adebar, Niklas, Hiessl, Robert, Kleber, Joscha, Grimm, Axel, Langsch, Angelika, Otter, Rainer, Liese, Andreas, Gröger, Harald

“…The Front Cover illustrates a concept to switch the raw material basis for plasticizer production from fossil to bio‐based feedstocks. The bicyclic…”
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Additional oxidized and alkyl chain breakdown metabolites of the plasticizer DINCH in urine after oral dosage to human volunteers by Schütze, André, Otter, Rainer, Modick, Hendrik, Langsch, Angelika, Brüning, Thomas, Koch, Holger M.

“…Hexamoll ® DINCH ® (diisononyl-cyclohexane-1,2-dicarboxylate) is a new high molecular weight plasticizer and a non-aromatic phthalate substitute. In this…”
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Inefficacy of dietary test substance administration in Amphibian Metamorphosis Assay (AMA) studies by Fort, Douglas J., Wolf, Jeffrey C., Langsch, Angelika, Fast, Beate, Junker, Markus, Otter, Rainer

“…Traditionally, the Amphibian Metamorphosis Assay (AMA; OECD TG 231) is performed by exposing Xenopus laevis tadpoles to test substances dissolved in laboratory…”
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Metabolism and urinary excretion kinetics of di(2-ethylhexyl) terephthalate (DEHTP) in three male volunteers after oral dosage by Lessmann, Frederik, Schütze, André, Weiss, Tobias, Langsch, Angelika, Otter, Rainer, Brüning, Thomas, Koch, Holger M.

“…Di(2-ethylhexyl) terephthalate (DEHTP) is used as a substitute for di(2-ethylhexyl) phthalate (DEHP), an ortho-phthalate-based plasticizer that is classified…”
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Urinary metabolite excretion after oral dosage of bis(2-propylheptyl) phthalate (DPHP) to five male volunteers – Characterization of suitable biomarkers for human biomonitoring by Leng, Gabriele, Koch, Holger M., Gries, Wolfgang, Schütze, Andre, Langsch, Angelika, Brüning, Thomas, Otter, Rainer

“…•Urinary excretion of three specific, secondary, oxidized metabolites (oxo-MPHP, OH-MPHP and cx-MPHxP) of DPHP was monitored following oral uptake by five…”
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Hexamoll® DINCH: Lack of in vivo evidence for obesogenic properties by Langsch, Angelika, David, Raymond M., Schneider, Steffen, Sperber, Saskia, Haake, Volker, Kamp, Hennicke, Leibold, Edgar, Ravenzwaay, Bennard van, Otter, Rainer

“…•In vivo data do not show any evidence of Hexamoll® DINCH having obesogenic properties.•No effects on body weight, total cholesterol values or lipid…”
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Towards bio-based plasticizers with reduced toxicity: Synthesis and performance testing of a 3-methylphthalate by Plass, Carmen, Hiessl, Robert, Kleber, Joscha, Grimm, Axel, Langsch, Angelika, Otter, Rainer, Liese, Andreas, Gröger, Harald

“…As a very durable material, soft polyvinyl chloride (PVC) is used for many applications in the field of consumer products. To enable the desired properties,…”
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Automatic sorting of toxicological information into the IUCLID (International Uniform Chemical Information Database) endpoint-categories making use of the semantic search engine Go3R by Sauer, Ursula G., Wächter, Thomas, Hareng, Lars, Wareing, Britta, Langsch, Angelika, Zschunke, Matthias, Alvers, Michael R., Landsiedel, Robert

“…•Go3R is a semantic search engine for Internet searches on in vitro test methods.•The expert knowledge for the search engine is contained in a so-called…”
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Endpoint-centric search to support the information retrieval for regulatory programs by Lansiedel, Robert, Wächter, Thomas, Sauer, Ursula G., Wareing, Britta, Huhse, Bettina, Langsch, Angelika, Grune, Babara, Luch, Andreas, Schroeder, Michael

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A membrane-based small-scale bioreactor for accelerated in vitro drug screenings with primary hepatocytes by Schmitmeier, Stephanie, Langsch, Angelika, Bader, Augustinus

“…The use of primary hepatocyte cultures is well established for the study of drug metabolism and drug-drug interactions. However, the application of these cells…”
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New Hepatocyte In Vitro Systems for Drug Metabolism: Metabolic Capacity and Recommendations for Application in Basic Research and Drug Development, Standard Operation Procedures by Gebhardt, Rolf, Hengstler, Jan G., Müller, Dieter, Glöckner, Reinhild, Buenning, Peter, Laube, Britta, Schmelzer, Eva, Ullrich, Martina, Utesch, Dietmar, Nicola Hewitt, Ringel, Michael, Hilz, Beate Reder, Bader, Augustinus, Langsch, Angelika, Koose, Thomas, Burger, Hans-Jörg, Maas, Jochen, Oesch, Franz

“…Primary hepatocytes represent a well-accepted in vitro cell culture system for studies of drug metabolism, enzyme induction, transplantation, viral hepatitis,…”
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Improvement of metabolic performance of primary hepatocytes in hyperoxic cultures by vitamin C in a novel small-scale bioreactor by Schmitmeier, Stephanie, Langsch, Angelika, Schmidt-Heck, Wolfgang, Jasmund, Inka, Bader, Augustinus

“…Our small-scale bioreactor with a gas-permeable membrane has previously been shown to allow direct oxygenation of primary hepatocytes in collagenous sandwich…”
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