Search Results - "Langley, Elizabeth"
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Exosomal lncRNAs as regulators of breast cancer chemoresistance and metastasis and their potential use as biomarkers
Published in Frontiers in oncology (01-08-2024)“…Breast cancer is the most common cancer in women and the leading cause of female deaths by cancer in the world worldwide. Hence, understanding the molecular…”
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Case Report: Novel pathogenic variant in NFIX in two sisters with Malan syndrome due to germline mosaicism
Published in Frontiers in genetics (09-11-2022)“…Malan syndrome is an autosomal dominant disorder caused by pathogenic variants in NFIX with less than 100 cases reported thus far. NFIX is important for stem…”
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3
Comparative genomics in chicken and Pekin duck using FISH mapping and microarray analysis
Published in BMC genomics (05-08-2009)“…The availability of the complete chicken (Gallus gallus) genome sequence as well as a large number of chicken probes for fluorescent in-situ hybridization…”
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4
Copy number variation, chromosome rearrangement, and their association with recombination during avian evolution
Published in Genome research (01-04-2010)“…Chromosomal rearrangements and copy number variants (CNVs) play key roles in genome evolution and genetic disease; however, the molecular mechanisms underlying…”
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LncRNA SOX9-AS1 triggers a transcriptional program involved in lipid metabolic reprogramming, cell migration and invasion in triple-negative breast cancer
Published in Scientific reports (17-01-2024)“…At the molecular level, triple-negative breast cancer (TNBC) is frequently categorized as PAM50 basal-like subtype, but despite the advances in molecular…”
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6
Non-Coding RNAs as Key Regulators of Glutaminolysis in Cancer
Published in International journal of molecular sciences (20-04-2020)“…Cancer cells exhibit exacerbated metabolic activity to maintain their accelerated proliferation and microenvironmental adaptation in order to survive under…”
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7
Production of microbial secondary metabolites: regulation by the carbon source
Published in Critical reviews in microbiology (01-05-2010)“…Microbial secondary metabolites are low molecular mass products, not essential for growth of the producing cultures, but very important for human health. They…”
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Critical Role of the Transcription Factor AKNA in T-Cell Activation: An Integrative Bioinformatics Approach
Published in International journal of molecular sciences (01-02-2023)“…The human gene encodes an AT-hook transcription factor, the expression of which is involved in various cellular processes. The goal of this study was to…”
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9
Carbon source regulation of antibiotic production
Published in Journal of antibiotics (01-08-2010)“…Antibiotics are low-molecular-mass products of secondary metabolism, nonessential for the growth of producing organisms, but very important for human health…”
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10
BCAS2 Enhances Carcinogenic Effects of Estrogen Receptor Alpha in Breast Cancer Cells
Published in International journal of molecular sciences (22-02-2019)“…Estrogen receptor alpha (ERα) has an established role in breast cancer biology. Transcriptional activation by ERα is a multistep process modulated by…”
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Breast Cancer Stem Cells and Sex Steroid Hormones
Published in Current stem cell research & therapy (01-01-2019)“…Breast cancer stem cells (BCSCs) are a small population of tumor-initiating cells that express stem cell-associated markers. In recent years, their properties…”
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12
Heterologous expression of lasso peptides with apparent participation in the morphological development in Streptomyces
Published in AMB Express (03-09-2024)“…Lasso peptides, ribosomally synthesized and post-translationally modified peptides, are primarily produced by bacteria and some archaea. Streptomyces lasso…”
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CD24+CD44+CD54+EpCAM+ gastric cancer stem cells predict tumor progression and metastasis: clinical and experimental evidence
Published in Stem cell research & therapy (03-02-2023)“…Gastric cancer (GC) is a leading cause of cancer-related deaths worldwide. Specific and thorough identification of cancer cell subsets with higher…”
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14
Mycobacterium tuberculosis whiB3 and Lipid Metabolism Genes Are Regulated by Host Induced Oxidative Stress
Published in Microorganisms (Basel) (11-09-2022)“…The physiological state of the human macrophage may impact the metabolism and the persistence of . This pathogen senses and counters the levels of O , CO,…”
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Potential Transcript-Based Biomarkers Predicting Clinical Outcomes of HPV-Positive Head and Neck Squamous Cell Carcinoma Patients
Published in Cells (Basel, Switzerland) (26-06-2024)“…Human papillomavirus (HPV)-positive Head and Neck Squamous Cell Carcinomas (HNSCC) comprise a particular cancer entity traditionally associated with better…”
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SFRP1 increases TMPRSS2-ERG expression promoting neoplastic features in prostate cancer in vitro and in vivo
Published in Cancer cell international (16-07-2020)“…Prostate cancer (PCa) is the second cause of cancer related death in North American men. Androgens play an important role in its progression by regulating the…”
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SOX2 as a New Regulator of HPV16 Transcription
Published in Viruses (05-07-2017)“…Persistent infections with high-risk human papillomavirus (HPV) constitute the main risk factor for cervical cancer development. HPV16 is the most frequent…”
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Intermolecular NH2-/Carboxyl-terminal Interactions in Androgen Receptor Dimerization Revealed by Mutations That Cause Androgen Insensitivity
Published in The Journal of biological chemistry (02-01-1998)“…Structural alignment of the human androgen receptor dimer was investigated by introducing steroid binding domain mutations that cause partial or complete…”
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Distinguishing Androgen Receptor Agonists and Antagonists: Distinct Mechanisms of Activation by Medroxyprogesterone Acetate and Dihydrotestosterone
Published in Molecular endocrinology (Baltimore, Md.) (01-03-1999)“…Natural and pharmacological androgen receptor (AR) ligands were tested for their ability to induce the AR NH2-terminal and carboxyl-terminal (N/C) interaction…”
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Evidence for an Anti-parallel Orientation of the Ligand-activated Human Androgen Receptor Dimer (∗)
Published in The Journal of biological chemistry (15-12-1995)“…Domain interactions of the human androgen receptor (AR) dimer were investigated using a protein-protein interaction assay in which the NH2- and…”
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