Search Results - "Langley, David B."

Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination by Burnett, Deborah L, Langley, David B, Schofield, Peter, Hermes, Jana R, Chan, Tyani D, Jackson, Jennifer, Bourne, Katherine, Reed, Joanne H, Patterson, Kate, Porebski, Benjamin T, Brink, Robert, Christ, Daniel, Goodnow, Christopher C

“…Antibodies have the specificity to differentiate foreign antigens that mimic self antigens, but it remains unclear how such specificity is acquired. In a mouse…”
Get full text

Next-Generation Sequencing of Antibody Display Repertoires by Rouet, Romain, Jackson, Katherine J L, Langley, David B, Christ, Daniel

“…selection technology has transformed the development of therapeutic monoclonal antibodies. Using methods such as phage, ribosome, and yeast display, high…”
Get full text

Surface-associated antigen induces permeabilization of primary mouse B-cells and lysosome exocytosis facilitating antigen uptake and presentation to T-cells by Maeda, Fernando Y, van Haaren, Jurriaan Jh, Langley, David B, Christ, Daniel, Andrews, Norma W, Song, Wenxia

“…B-cell receptor (BCR)-mediated antigen internalization and presentation are essential for humoral memory immune responses. Antigen encountered by B-cells is…”
Get full text

Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies by Rouet, Romain, Mazigi, Ohan, Walker, Gregory J., Langley, David B., Sobti, Meghna, Schofield, Peter, Lenthall, Helen, Jackson, Jennifer, Ubiparipovic, Stephanie, Henry, Jake Y., Abayasingam, Arunasingam, Burnett, Deborah, Kelleher, Anthony, Brink, Robert, Bull, Rowena A., Turville, Stuart, Stewart, Alastair G., Goodnow, Christopher C., Rawlinson, William D., Christ, Daniel

“…Antibodies against coronavirus spike protein potently protect against infection and disease, but whether such protection can be extended to variant…”
Get full text

Preparing monodisperse macromolecular samples for successful biological small-angle X-ray and neutron-scattering experiments by Jeffries, Cy M, Graewert, Melissa A, Blanchet, Clément E, Langley, David B, Whitten, Andrew E, Svergun, Dmitri I

Get full text

Cytosolic Recognition of RNA Drives the Immune Response to Heterologous Erythrocytes by Loetsch, Claudia, Warren, Joanna, Laskowski, Adrienne, Vazquez-Lombardi, Rodrigo, Jandl, Christoph, Langley, David B., Christ, Daniel, Thorburn, David R., Ryugo, David K., Sprent, Jonathan, Batten, Marcel, King, Cecile

“…The archetypal T cell-dependent antigen is sheep red blood cells (SRBCs), which have defined much of what we know about humoral immunity. Early studies using…”
Get full text

Structural Basis for Hemoglobin Capture by Staphylococcus aureus Cell-surface Protein, IsdH by Krishna Kumar, Kaavya, Jacques, David A., Pishchany, Gleb, Caradoc-Davies, Tom, Spirig, Thomas, Malmirchegini, G. Reza, Langley, David B., Dickson, Claire F., Mackay, Joel P., Clubb, Robert T., Skaar, Eric P., Guss, J. Mitchell, Gell, David A.

“…Pathogens must steal iron from their hosts to establish infection. In mammals, hemoglobin (Hb) represents the largest reservoir of iron, and pathogens express…”
Get full text

Structural Basis for Partial Redundancy in a Class of Transcription Factors, the LIM Homeodomain Proteins, in Neural Cell Type Specification by Gadd, Morgan S., Bhati, Mugdha, Jeffries, Cy M., Langley, David B., Trewhella, Jill, Guss, J. Mitchell, Matthews, Jacqueline M.

“…Combinations of LIM homeodomain proteins form a transcriptional “LIM code” to direct the specification of neural cell types. Two paralogous pairs of LIM…”
Get full text

I-motif DNA structures are formed in the nuclei of human cells by Zeraati, Mahdi, Langley, David B., Schofield, Peter, Moye, Aaron L., Rouet, Romain, Hughes, William E., Bryan, Tracy M., Dinger, Marcel E., Christ, Daniel

“…Human genome function is underpinned by the primary storage of genetic information in canonical B-form DNA, with a second layer of DNA structure providing…”
Get full text

The Structure of the KinA-Sda Complex Suggests an Allosteric Mechanism of Histidine Kinase Inhibition by Whitten, Andrew E., Jacques, David A., Hammouda, Boualem, Hanley, Tracey, King, Glenn F., Guss, J. Mitchell, Trewhella, Jill, Langley, David B.

“…The Bacillus subtilis histidine kinase KinA controls activation of the transcription factor governing sporulation, Spo0A. The decision to sporulate involves…”
Get full text

A Novel Structure of an Antikinase and its Inhibitor by Jacques, David A., Langley, David B., Hynson, Robert M.G., Whitten, Andrew E., Kwan, Ann, Guss, J. Mitchell, Trewhella, Jill

“…In Bacillus subtilis, the KipI protein is a regulator of the phosphorelay governing the onset of sporulation. KipI binds the relevant sensor histidine kinase,…”
Get full text

Preparing monodisperse macromolecular samples for successful biological small-angle X-ray and neutron-scattering experiments by Jeffries, Cy M, Graewert, Melissa A, Blanchet, Clément E, Langley, David B, Whitten, Andrew E, Svergun, Dmitri I

“…Small-angle X-ray and neutron scattering are used to extract structural parameters and derive structural models of macromolecules in solution. The preparation…”
Get full text

Crystal structures of human neuropeptide Y (NPY) and peptide YY (PYY) by Langley, David B., Schofield, Peter, Jackson, Jenny, Herzog, Herbert, Christ, Daniel

“…Neuropeptide Y (NPY), peptide YY (PYY) and pancreatic polypeptide (PP) form the evolutionarily conserved pancreatic polypeptide family. While the fold is…”
Get full text

Protein A superantigen: structure, engineering and molecular basis of antibody recognition by Mazigi, Ohan, Schofield, Peter, Langley, David B, Christ, Daniel

“…Abstract Staphylococcus aureus interacts with the human immune system through the production of secreted factors. Key among these is protein A, a B-cell…”
Get full text

Immunizations with diverse sarbecovirus receptor-binding domains elicit SARS-CoV-2 neutralizing antibodies against a conserved site of vulnerability by Burnett, Deborah L., Jackson, Katherine J.L., Langley, David B., Aggarwal, Anupriya, Stella, Alberto Ospina, Johansen, Matt D., Balachandran, Harikrishnan, Lenthall, Helen, Rouet, Romain, Walker, Gregory, Saunders, Bernadette M., Singh, Mandeep, Li, Hui, Henry, Jake Y., Jackson, Jennifer, Stewart, Alastair G., Witthauer, Franka, Spence, Matthew A., Hansbro, Nicole G., Jackson, Colin, Schofield, Peter, Milthorpe, Claire, Martinello, Marianne, Schulz, Sebastian R., Roth, Edith, Kelleher, Anthony, Emery, Sean, Britton, Warwick J., Rawlinson, William D., Karl, Rudolfo, Schäfer, Simon, Winkler, Thomas H., Brink, Robert, Bull, Rowena A., Hansbro, Philip M., Jäck, Hans-Martin, Turville, Stuart, Christ, Daniel, Goodnow, Christopher C.

“…Viral mutations are an emerging concern in reducing SARS-CoV-2 vaccination efficacy. Second-generation vaccines will need to elicit neutralizing antibodies…”
Get full text

Crystal structure of duck egg lysozyme isoform II (DEL-II) by Langley, David B, Christ, Daniel

“…Lysozyme purified from duck eggs (DEL) has long been used as a model antigen as a counterpoint to the enzyme purified from hen eggs (HEL). However, unlike the…”
Get full text

Genetic and structural basis of the human anti-α-galactosyl antibody response by Langley, David B, Schofield, Peter, Nevoltris, Damien, Jackson, Jennifer, Jackson, Katherine J L, Peters, Tim J, Burk, Melanie, Matthews, Jacqueline M, Basten, Antony, Goodnow, Christopher C, van Nunen, Sheryl, Reed, Joanne H, Christ, Daniel

“…Humans lack the capacity to produce the Galα1-3Galβ1-4GlcNAc (α-gal) glycan, and produce anti-α-gal antibodies upon exposure to the carbohydrate on a diverse…”
Get full text

Enantiomer-Specific Binding of Ruthenium(II) Molecular Wires by the Amine Oxidase of Arthrobacter globiformis by Langley, David B, Brown, Doreen E, Cheruzel, Lionel E, Contakes, Stephen M, Duff, Anthony P, Hilmer, Kimberly M, Dooley, David M, Gray, Harry B, Guss, J. Mitchell, Freeman, Hans C

“…The copper amine oxidase from Arthrobacter globiformis (AGAO) is reversibly inhibited by molecular wires comprising a Ru(II) complex head group and an aromatic…”
Get full text

Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens by Burnett, Deborah L., Schofield, Peter, Langley, David B., Jackson, Jennifer, Bourne, Katherine, Wilson, Emily, Porebski, Benjamin T., Buckle, Ashley M., Brink, Robert, Goodnow, Christopher C., Christ, Daniel

“…Conformational diversity and self-cross-reactivity of antigens have been correlated with evasion from neutralizing antibody responses. We utilized single cell…”
Get full text

Using Xenon as a Probe for Dioxygen-binding Sites in Copper Amine Oxidases by Duff, Anthony P., Trambaiolo, Daniel M., Cohen, Aina E., Ellis, Paul J., Juda, Gregory A., Shepard, Eric M., Langley, David B., Dooley, David M., Freeman, Hans C., Guss, J. Mitchell

“…Potential dioxygen-binding sites in three Cu amine oxidases have been investigated by recording X-ray diffraction data at 1.7–2.2 Å resolution for crystals…”
Get full text