Search Results - "Langhan, Michelle M."

A Phase II Study of Tumor-infiltrating Lymphocyte Therapy for Human Papillomavirus-associated Epithelial Cancers by Stevanović, Sanja, Helman, Sarah R, Wunderlich, John R, Langhan, Michelle M, Doran, Stacey L, Kwong, Mei Li M, Somerville, Robert P T, Klebanoff, Christopher A, Kammula, Udai S, Sherry, Richard M, Yang, James C, Rosenberg, Steven A, Hinrichs, Christian S

“…Cellular therapy is an emerging cancer treatment modality, but its application to epithelial cancers has been limited. This clinical trial evaluated…”
Get full text

CD8+ Enriched Young Tumor Infiltrating Lymphocytes Can Mediate Regression of Metastatic Melanoma by DUDLEY, Mark E, GROSS, Colin A, RESTIFO, Nicholas P, WUNDERLICH, John R, PRIETO, Peter A, HONG, Jenny J, LANGAN, Russell C, ZLOTT, Daniel A, MORTON, Kathleen E, WHITE, Donald E, LAURENCOT, Carolyn M, ROSENBERG, Steven A, LANGHAN, Michelle M, GARCIA, Marcos R, SHERRY, Richard M, YANG, James C, PHAN, Giao Q, KAMMULA, Udai S, HUGHES, Marybeth S, CITRIN, Deborah E

“…Tumor-infiltrating lymphocytes (TIL) and interleukin (IL)-2 administered following lymphodepletion can cause the durable complete regression of bulky…”
Get full text

Minimally Cultured Tumor-infiltrating Lymphocytes Display Optimal Characteristics for Adoptive Cell Therapy by TRAN, Khoi Q, JUHUA ZHOU, DURFLMGER, Katherine H, LANGHAN, Michelle M, SHELTON, Thomas E, WUNDERLICH, John R, ROBBINS, Paul F, ROSENBERG, Steven A, DUDLEY, Mark E

“…Adoptive cell therapy (ACT) with tumor-reactive lymphocytes in patients with refractory melanoma can result in tumor regression and prolonged survival…”
Get full text

Complete regression of metastatic cervical cancer after treatment with human papillomavirus-targeted tumor-infiltrating T cells by Stevanović, Sanja, Draper, Lindsey M, Langhan, Michelle M, Campbell, Tracy E, Kwong, Mei Li, Wunderlich, John R, Dudley, Mark E, Yang, James C, Sherry, Richard M, Kammula, Udai S, Restifo, Nicholas P, Rosenberg, Steven A, Hinrichs, Christian S

“…Metastatic cervical cancer is a prototypical chemotherapy-refractory epithelial malignancy for which better treatments are needed. Adoptive T-cell therapy…”
Get full text

Randomized, Prospective Evaluation Comparing Intensity of Lymphodepletion Before Adoptive Transfer of Tumor-Infiltrating Lymphocytes for Patients With Metastatic Melanoma by Goff, Stephanie L, Dudley, Mark E, Citrin, Deborah E, Somerville, Robert P, Wunderlich, John R, Danforth, David N, Zlott, Daniel A, Yang, James C, Sherry, Richard M, Kammula, Udai S, Klebanoff, Christopher A, Hughes, Marybeth S, Restifo, Nicholas P, Langhan, Michelle M, Shelton, Thomas E, Lu, Lily, Kwong, Mei Li M, Ilyas, Sadia, Klemen, Nicholas D, Payabyab, Eden C, Morton, Kathleen E, Toomey, Mary Ann, Steinberg, Seth M, White, Donald E, Rosenberg, Steven A

“…Adoptive cell transfer, the infusion of large numbers of activated autologous lymphocytes, can mediate objective tumor regression in a majority of patients…”
Get full text

T-cell Responses to TP53 "Hotspot" Mutations and Unique Neoantigens Expressed by Human Ovarian Cancers by Deniger, Drew C, Pasetto, Anna, Robbins, Paul F, Gartner, Jared J, Prickett, Todd D, Paria, Biman C, Malekzadeh, Parisa, Jia, Li, Yossef, Rami, Langhan, Michelle M, Wunderlich, John R, Danforth, David N, Somerville, Robert P T, Rosenberg, Steven A

“…This was a study prospectively evaluating intratumoral T-cell responses to autologous somatic mutated neoepitopes expressed by human metastatic ovarian…”
Get full text

Breast Cancers Are Immunogenic: Immunologic Analyses and a Phase II Pilot Clinical Trial Using Mutation-Reactive Autologous Lymphocytes by Zacharakis, Nikolaos, Huq, Lutfi M, Seitter, Samantha J, Kim, Sanghyun P, Gartner, Jared J, Sindiri, Sivasish, Hill, Victoria K, Li, Yong F, Paria, Biman C, Ray, Satyajit, Gasmi, Billel, Lee, Chyi-Chia, Prickett, Todd D, Parkhurst, Maria R, Robbins, Paul F, Langhan, Michelle M, Shelton, Thomas E, Parikh, Anup Y, Levi, Shoshana T, Hernandez, Jonathan M, Hoang, Chuong D, Sherry, Richard M, Yang, James C, Feldman, Steven A, Goff, Stephanie L, Rosenberg, Steven A

“…Metastatic breast cancer (mBrCa) is most often an incurable disease with only modest responses to available immunotherapies. This study investigates the…”
Get full text

Impact of Prior Treatment on the Efficacy of Adoptive Transfer of Tumor-Infiltrating Lymphocytes in Patients with Metastatic Melanoma by Seitter, Samantha J, Sherry, Richard M, Yang, James C, Robbins, Paul F, Shindorf, Mackenzie L, Copeland, Amy R, McGowan, Christine T, Epstein, Monica, Shelton, Thomas E, Langhan, Michelle M, Franco, Zulmarie, Danforth, David N, White, Donald E, Rosenberg, Steven A, Goff, Stephanie L

“…Adoptive cell transfer (ACT) of autologous tumor-infiltrating lymphocytes (TIL) can mediate durable responses in patients with metastatic melanoma. This…”
Get full text

A Pilot Trial of the Combination of Vemurafenib with Adoptive Cell Therapy in Patients with Metastatic Melanoma by Deniger, Drew C, Kwong, Mei Li M, Pasetto, Anna, Dudley, Mark E, Wunderlich, John R, Langhan, Michelle M, Lee, Chyi-Chia Richard, Rosenberg, Steven A

“…This pilot feasibility clinical trial evaluated the coadministration of vemurafenib, a small-molecule antagonist of BRAF mutations, and tumor-infiltrating…”
Get full text

Treatment of metastatic human papillomavirus-associated epithelial cancers with adoptive transfer of tumor-infiltrating T cells by Stevanovic, Sanja, Helman, Sarah R., Wunderlich, John R., Langhan, Michelle M., Doran, Stacey L., Kwong, Mei Li M., Somerville, Robert P., Klebanoff, Christopher Austin, Kammula, Udai, Sherry, Richard Mark, Yang, James C., Rosenberg, Steven A., Hinrichs, Christian S.

“…Abstract only…”
Get full text