Search Results - "Langford, Catherine"

Enhanced Sensitivity of Patient-Derived Pediatric High-Grade Brain Tumor Xenografts to Oncolytic HSV-1 Virotherapy Correlates with Nectin-1 Expression by Friedman, Gregory K., Bernstock, Joshua D., Chen, Dongquan, Nan, Li, Moore, Blake P., Kelly, Virginia M., Youngblood, Samantha L., Langford, Catherine P., Han, Xiaosi, Ring, Eric K., Beierle, Elizabeth A., Gillespie, G. Yancey, Markert, James M.

“…Pediatric high-grade brain tumors and adult glioblastoma are associated with significant morbidity and mortality. Oncolytic herpes simplex virus-1 (oHSV) is a…”
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A combined treatment regimen of MGMT-modified γδ T cells and temozolomide chemotherapy is effective against primary high grade gliomas by Lamb, Lawrence S., Pereboeva, Larisa, Youngblood, Samantha, Gillespie, G. Yancey, Nabors, L. Burton, Markert, James M., Dasgupta, Anindya, Langford, Catherine, Spencer, H. Trent

“…Chemotherapeutic drugs such as the alkylating agent Temozolomide (TMZ), in addition to reducing tumor mass, can also sensitize tumors to immune recognition by…”
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ROCK Inhibition Facilitates In Vitro Expansion of Glioblastoma Stem-Like Cells by Tilson, Samantha G, Haley, Elizabeth M, Triantafillu, Ursula L, Dozier, David A, Langford, Catherine P, Gillespie, G Yancey, Kim, Yonghyun

“…Due to their stem-like characteristics and their resistance to existing chemo- and radiation therapies, there is a growing appreciation that cancer stem cells…”
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Therapeutic potential of AZD1480 for the treatment of human glioblastoma by McFarland, Braden C, Ma, Jing-Yuan, Langford, Catherine P, Gillespie, G Yancey, Yu, Hao, Zheng, Ying, Nozell, Susan E, Huszar, Dennis, Benveniste, Etty N

“…Aberrant activation of the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway has been implicated in glioblastoma (GBM)…”
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Myristoylated alanine-rich C-kinase substrate effector domain phosphorylation regulates the growth and radiation sensitization of glioblastoma by Eustace, Nicholas J, Anderson, Joshua C, Langford, Catherine P, Trummell, Hoa Q, Hicks, Patricia H, Jarboe, John S, Mobley, James A, Hjelmeland, Anita B, Hackney, James R, Pedersen, Rune T, Cosby, Kadia, Gillespie, G Yancey, Bonner, James A, Willey, Christopher D

“…Glioblastoma harbors frequent alterations in receptor tyrosine kinases, phosphatidylinositol‑3 kinase (PI3K) and phosphatase and tensin homolog (PTEN) that…”
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Pediatric medulloblastoma xenografts including molecular subgroup 3 and CD133+ and CD15+ cells are sensitive to killing by oncolytic herpes simplex viruses by Friedman, Gregory K, Moore, Blake P, Nan, Li, Kelly, Virginia M, Etminan, Tina, Langford, Catherine P, Xu, Hui, Han, Xiaosi, Markert, James M, Beierle, Elizabeth A, Gillespie, G Yancey

“…Childhood medulloblastoma is associated with significant morbidity and mortality that is compounded by neurotoxicity for the developing brain caused by current…”
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The role of Src family kinases in growth and migration of glioma stem cells by HAN, XIAOSI, ZHANG, WENBIN, YANG, XIUHUA, WHEELER, CRYSTAL G, LANGFORD, CATHERINE P, WU, LU, FILIPPOVA, NATALIA, FRIEDMAN, GREGORY K, DING, QIANG, FATHALLAH-SHAYKH, HASSAN M, GILLESPIE, G. YANCEY, NABORS, L. BURT

“…Src family kinases (SFKs) are highly expressed and active in clinical glioblastoma multiforme (GBM) specimens. SFKs inhibitors have been demonstrated to…”
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Combinatorial Drug Testing in 3D Microtumors Derived from GBM Patient-Derived Xenografts Reveals Cytotoxic Synergy in Pharmacokinomics-informed Pathway Interactions by Gilbert, Ashley N., Anderson, Joshua C., Duarte, Christine W., Shevin, Rachael S., Langford, Catherine P., Singh, Raj, Gillespie, G. Yancey, Willey, Christopher D.

“…Glioblastoma multiforme (GBM), the most common form of primary malignant brain cancer in adults, is a devastating disease for which effective treatment has…”
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Dynamics of Circulating γδ T Cell Activity in an Immunocompetent Mouse Model of High-Grade Glioma by Beck, Benjamin H, Kim, Hyunggoon, O'Brien, Rebecca, Jadus, Martin R, Gillespie, G Yancey, Cloud, Gretchen A, Hoa, Neil T, Langford, Catherine P, Lopez, Richard D, Harkins, Lualhati E, Lamb, Jr, Lawrence S

“…Human γδ T cells are potent effectors against glioma cell lines in vitro and in human/mouse xenograft models of glioblastoma, however, this effect has not been…”
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An in vivo model of glioblastoma radiation resistance identifies long noncoding RNAs and targetable kinases by Stackhouse, Christian T., Anderson, Joshua C., Yue, Zongliang, Nguyen, Thanh, Eustace, Nicholas J., Langford, Catherine P., Wang, Jelai, Rowland, James R., Xing, Chuan, Mikhail, Fady M., Cui, Xiangqin, Alrefai, Hasan, Bash, Ryan E., Lee, Kevin J., Yang, Eddy S., Hjelmeland, Anita B., Miller, C. Ryan, Chen, Jake Y., Gillespie, G. Yancey, Willey, Christopher D.

“…Key molecular regulators of acquired radiation resistance in recurrent glioblastoma (GBM) are largely unknown, with a dearth of accurate preclinical models. To…”
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Engineered herpes simplex viruses efficiently infect and kill CD133+ human glioma xenograft cells that express CD111 by Friedman, Gregory K., Langford, Catherine P., Coleman, Jennifer M., Cassady, Kevin A., Parker, Jacqueline N., Markert, James M., Yancey Gillespie, G.

“…Oncolytic herpes simplex viruses (HSV) hold promise for therapy of glioblastoma multiforme (GBM) resistant to traditional therapies. We examined the ability of…”
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Generation of Microtumors Using 3D Human Biogel Culture System and Patient-derived Glioblastoma Cells for Kinomic Profiling and Drug Response Testing by Gilbert, Ashley N, Shevin, Rachael S, Anderson, Joshua C, Langford, Catherine P, Eustace, Nicholas, Gillespie, G Yancey, Singh, Raj, Willey, Christopher D

“…The use of patient-derived xenografts for modeling cancers has provided important insight into cancer biology and drug responsiveness. However, they are time…”
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Preclinical evaluation of ex vivo expanded/activated gamma delta T cells for immunotherapy of glioblastoma multiforme by Bryant, Nichole L, Gillespie, GYancey, Lopez, Richard D, Markert, James M, Cloud, Gretchen A, Langford, Catherine P, Arnouk, Hilal, Su, Yun, Haines, Hilary L, Suarez-Cuervo, Catalina, Lamb, Lawrence S

“…We have previously shown that expanded/activated gamma delta T cells from healthy donors are cytotoxic to GBM cell lines and primary GBM explants. In this…”
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Preclinical evaluation of ex vivo expanded/activated γδ T cells for immunotherapy of glioblastoma multiforme by Bryant, Nichole L., Gillespie, G. Yancey, Lopez, Richard D., Markert, James M., Cloud, Gretchen A., Langford, Catherine P., Arnouk, Hilal, Su, Yun, Haines, Hilary L., Suarez-Cuervo, Catalina, Lamb, Lawrence S.

“…We have previously shown that expanded/activated γδ T cells from healthy donors are cytotoxic to GBM cell lines and primary GBM explants. In this report, we…”
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Effect of HSV-IL12 Loaded Tumor Cell-Based Vaccination in a Mouse Model of High-Grade Neuroblastoma by Jr., Lawrence S. Lamb, Langford, Catherine, Elzafarany, Osama, Cloud, Gretchen A., Yancey Gillespie, G., Pereboeva, Larisa, Bauer, David F., Markert, James M.

“…We designed multimodal tumor vaccine that consists of irradiated tumor cells infected with the oncolytic IL-12-expressing HSV-1 virus, M002. This vaccine was…”
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Increased efficacy of an interleukin-12-secreting herpes simplex virus in a syngeneic intracranial murine glioma model by Hellums, Elizabeth K, Markert, James M, Parker, Jacqueline N, He, Bin, Perbal, Bernard, Roizman, Bernard, Whitley, Richard J, Langford, Catherine P, Bharara, Suman, Gillespie, G Yancey

“…Long-term survivors of glioblastoma multiforme, the most common form of primary intracranial malignancy in adults, are extremely rare. Experimental animal…”
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Social support: a conceptual analysis by Langford, Catherine Penny Hinson, Bowsher, Juanita, Maloney, Joseph P., Lillis, Patricia P.

“…Using the methodology of Walker and Avant, the purpose of this paper was to identify the most frequently used theoretical and operational definitions of social…”
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Commonplace Witnessing: Rhetorical Invention, Historical Remembrance, and Public Culture by Bradford Vivian (review) by Langford, Catherine L

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Abstract 2262: Chemotherapy, checkpoint inhibition, and MGMT-modified adoptive gamma-delta (γδ) T cell-based therapy to treat post-resection, primary glioblastomas by Pillai, Sailesh, Gillespie, George Y., Nabors, Louis B., Langford, Samantha, Langford, Catherine P., Lamb, Lawrence S.

“…Introduction: Recent evidence supports the crucial contribution of innate immunity to chemotherapy-based cancer treatments. Our previous in vitro modeling…”
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A Descriptive Study: Factors Influencing Information Technology Software and Services Professionals Assigned to Federal Organizations Decision to Leave by Langford, Catherine P

“…This descriptive qualitative study examined influencing retention factors in the Federal Information Technology (IT) workforce community given the high…”
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