Search Results - "Langer, Harald F"

Immune mechanisms in heart failure by Zhang, Yingying, Bauersachs, Johann, Langer, Harald F.

“…Elevated levels of circulating pro‐inflammatory biomarkers in patients with both ischaemic and non‐ischaemic heart failure (HF) correlate with disease severity…”
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Platelets as Mediators of Neuroinflammation and Thrombosis by Rawish, Elias, Nording, Henry, Münte, Thomas, Langer, Harald F

“…Beyond platelets function in hemostasis, there is emerging evidence to suggest that platelets contribute crucially to inflammation and immune responses…”
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Leukocyte – endothelial interactions in inflammation by Langer, Harald F., Chavakis, Triantafyllos

“…•  Introduction •  Adhesion molecules •  Leukocyte margination, capture and cell rolling •  Activation and adhesion of leukocytes •  Transmigration • …”
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Platelets and the Role of P2X Receptors in Nociception, Pain, Neuronal Toxicity and Thromboinflammation by Rawish, Elias, Langer, Harald F

“…P2X receptors belong to a family of cation channel proteins, which respond to extracellular adenosine 5'-triphosphate (ATP). These receptors have gained…”
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Complement, inflammation and thrombosis by Rawish, Elias, Sauter, Manuela, Sauter, Reinhard, Nording, Henry, Langer, Harald F.

“…A mutual relationship exists between immune activation and mechanisms of thrombus formation. In particular, elements of the innate immune response such as the…”
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Platelets in inflammation and atherogenesis by Nording, Henry M, Seizer, Peter, Langer, Harald F

“…Platelets contribute to processes beyond thrombus formation and may play a so far underestimated role as an immune cell in various circumstances. This review…”
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Platelets, Thromboinflammation and Neurovascular Disease by Sun, Ying, Langer, Harald F

“…The brain and spinal cord are immune-privileged organs, but in the disease state protection mechanisms such as the blood brain barrier (BBB) are ineffective or…”
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The Platelet Response to Tissue Injury by Eisinger, Felix, Patzelt, Johannes, Langer, Harald F

“…In recent years, various studies have increasingly explained platelet functions not only in their central role as a regulator in cellular hemostasis and…”
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An unexpected cellular fountain of youth: platelets provide factors rejuvenating brain functions by Langer, Harald F.

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Differential retrotranslocation of mitochondrial Bax and Bak by Todt, Franziska, Cakir, Zeynep, Reichenbach, Frank, Emschermann, Frederic, Lauterwasser, Joachim, Kaiser, Andrea, Ichim, Gabriel, Tait, Stephen WG, Frank, Stephan, Langer, Harald F, Edlich, Frank

“…The Bcl‐2 proteins Bax and Bak can permeabilize the outer mitochondrial membrane and commit cells to apoptosis. Pro‐survival Bcl‐2 proteins control Bax by…”
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Platelets and Immune Responses During Thromboinflammation by Mezger, Matthias, Nording, Henry, Sauter, Reinhard, Graf, Tobias, Heim, Christian, von Bubnoff, Nikolas, Ensminger, Stephan M, Langer, Harald F

“…Besides mediating hemostatic functions, platelets are increasingly recognized as important players of inflammation. Data from experiments in mice and men…”
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Novel Aspects Targeting Platelets in Atherosclerotic Cardiovascular Disease-A Translational Perspective by Huseynov, Aydin, Reinhardt, Julius, Chandra, Leonard, Dürschmied, Daniel, Langer, Harald F

“…Platelets are important cellular targets in cardiovascular disease. Based on insights from basic science, translational approaches and clinical studies, a…”
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Platelet-vessel wall interactions in atherosclerotic disease by Langer, Harald F, Gawaz, Meinrad

“…During the prolonged course of atherosclerotic disease, platelets are of central importance as they contribute to the initiation of the disease, to its…”
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Red blood cell-derived semaphorin 7A promotes thrombo-inflammation in myocardial ischemia-reperfusion injury through platelet GPIb by Köhler, David, Granja, Tiago, Volz, Julia, Koeppen, Michael, Langer, Harald F., Hansmann, Georg, Legchenko, Ekaterina, Geisler, Tobias, Bakchoul, Tamam, Eggstein, Claudia, Häberle, Helene A., Nieswandt, Bernhard, Rosenberger, Peter

“…Myocardial ischemia is one of the leading health problems worldwide. Therapy consists of the restitution of coronary perfusion which is followed by myocardial…”
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Functional Relevance of the Anaphylatoxin Receptor C3aR for Platelet Function and Arterial Thrombus Formation Marks an Intersection Point Between Innate Immunity and Thrombosis by Sauter, Reinhard J, Sauter, Manuela, Reis, Edimara S, Emschermann, Frederic N, Nording, Henry, Ebenhöch, Sonja, Kraft, Peter, Münzer, Patrick, Mauler, Maximilian, Rheinlaender, Johannes, Madlung, Johannes, Edlich, Frank, Schäffer, Tilman E, Meuth, Sven G, Dürschmied, Daniel, Geisler, Tobias, Borst, Oliver, Gawaz, Meinrad, Kleinschnitz, Christoph, Lambris, John D, Langer, Harald F

“…BACKGROUND:Platelets have distinct roles in the vascular system in that they are the major mediator of thrombosis, critical for restoration of tissue…”
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Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells by Göbel, Kerstin, Pankratz, Susann, Asaridou, Chloi-Magdalini, Herrmann, Alexander M., Bittner, Stefan, Merker, Monika, Ruck, Tobias, Glumm, Sarah, Langhauser, Friederike, Kraft, Peter, Krug, Thorsten F., Breuer, Johanna, Herold, Martin, Gross, Catharina C., Beckmann, Denise, Korb-Pap, Adelheid, Schuhmann, Michael K., Kuerten, Stefanie, Mitroulis, Ioannis, Ruppert, Clemens, Nolte, Marc W., Panousis, Con, Klotz, Luisa, Kehrel, Beate, Korn, Thomas, Langer, Harald F., Pap, Thomas, Nieswandt, Bernhard, Wiendl, Heinz, Chavakis, Triantafyllos, Kleinschnitz, Christoph, Meuth, Sven G.

“…Aberrant immune responses represent the underlying cause of central nervous system (CNS) autoimmunity, including multiple sclerosis (MS). Recent evidence…”
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Platelets in angiogenesis by Patzelt, Johannes, Langer, Harald F

“…Platelets hold an important function as first line of response to seal wounds after vascular and tissue injury. However, they are much more than just a…”
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Platelets and the complement cascade in atherosclerosis by Patzelt, Johannes, Verschoor, Admar, Langer, Harald F

“…Atherosclerosis and its late sequels are still the number one cause of death in western societies. Platelets are a driving force not only during the genesis of…”
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The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets by Nording, Henry, Baron, Lasse, Haberthür, David, Emschermann, Frederic, Mezger, Matthias, Sauter, Manuela, Sauter, Reinhard, Patzelt, Johannes, Knoepp, Kai, Nording, Anne, Meusel, Moritz, Meyer-Saraei, Roza, Hlushchuk, Ruslan, Sedding, Daniel, Borst, Oliver, Eitel, Ingo, Karsten, Christian M., Feil, Robert, Pichler, Bernd, Erdmann, Jeanette, Verschoor, Admar, Chavakis, Emmanouil, Chavakis, Triantafyllos, von Hundelshausen, Philipp, Köhl, Jörg, Gawaz, Meinrad, Langer, Harald F.

“…Platelets contribute to the regulation of tissue neovascularization, although the specific factors underlying this function are unknown. Here, we identified…”
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Inflammation in Metabolic and Cardiovascular Disorders—Role of Oxidative Stress by Sun, Ying, Rawish, Elias, Nording, Henry M., Langer, Harald F.

“…Cardiovascular diseases (CVD) constitute the main cause of death worldwide. Both inflammation and oxidative stress have been reported to be involved in the…”
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