Search Results - "Langenberg, Karin P.S."

Organoid-based drug screening reveals neddylation as therapeutic target for malignant rhabdoid tumors by Calandrini, Camilla, van Hooff, Sander R., Paassen, Irene, Ayyildiz, Dilara, Derakhshan, Sepide, Dolman, M. Emmy M., Langenberg, Karin P.S., van de Ven, Marieke, de Heus, Cecilia, Liv, Nalan, Kool, Marcel, de Krijger, Ronald R., Tytgat, Godelieve A.M., van den Heuvel-Eibrink, Marry M., Molenaar, Jan J., Drost, Jarno

“…Malignant rhabdoid tumors (MRTs) represent one of the most aggressive childhood malignancies. No effective treatment options are available, and prognosis is,…”
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P316: PRIORITIZING PRECISION MEDICINES IN PEDIATRIC BLOOD CANCER: EXPERIENCE OF THE DUTCH INDIVIDUALIZED THERAPY (ITHER) STUDY’S MOLECULAR TUMOR BOARD by Boer, Judith M., Ilan, Uri, Hoen, Babette D.J., Boeree, Aurelie, Langenberg, Karin P.S., Koster, Jan, Bourquin, Jean‐Pierre, Molenaar, Jan J., Goemans, Bianca, Den Boer, Monique L., Zwaan, Michel

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Paternal exposure to recreational drugs before conception and its effect on live‐born offspring: A scoping review by Verstegen, Ruud H.J., Wang, Guo, Langenberg‐Ververgaert, Karin P.S., Ren, Lily Yuxi, Nulman, Irena

“…Background Men of reproductive age increasingly use recreational drugs. While many of these substances may reduce the quantity and quality of sperm, less is…”
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The Landscape of Pediatric Precision Oncology: Program Design, Actionable Alterations, and Clinical Trial Development by Langenberg, Karin P S, Looze, Eleonora J, Molenaar, Jan J

“…Over the last years, various precision medicine programs have been developed for pediatric patients with high-risk, relapsed, or refractory malignancies,…”
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Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes by Meister, Michael T, Groot Koerkamp, Marian J A, de Souza, Terezinha, Breunis, Willemijn B, Frazer‐Mendelewska, Ewa, Brok, Mariël, DeMartino, Jeff, Manders, Freek, Calandrini, Camilla, Kerstens, Hinri H D, Janse, Alex, Dolman, M Emmy M, Eising, Selma, Langenberg, Karin P S, van Tuil, Marc, Knops, Rutger R G, van Scheltinga, Sheila Terwisscha, Hiemcke‐Jiwa, Laura S, Flucke, Uta, Merks, Johannes H M, van Noesel, Max M, Tops, Bastiaan B J, Hehir‐Kwa, Jayne Y, Kemmeren, Patrick, Molenaar, Jan J, van de Wetering, Marc, van Boxtel, Ruben, Drost, Jarno, Holstege, Frank C P

“…Rhabdomyosarcomas (RMS) are mesenchyme‐derived tumors and the most common childhood soft tissue sarcomas. Treatment is intense, with a nevertheless poor…”
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The pediatric precision oncology study INFORM: Clinical outcome and benefit for molecular subgroups by van Tilburg, Cornelis Martinus, Pfaff, Elke, Pajtler, Kristian W., Langenberg, Karin P.S., Fiesel, Petra, Jones, Barbara C., Balasubramanian, Gnana Prakash, Stark, Sebastian, Johann, Pascal D., Blattner-Johnson, Mirjam, Schramm, Kathrin, Jäger, Natalie, von Deimling, Andreas, Dirksen, Uta, Freitag, Angelika, Witt, Ruth, Lichter, Peter, Jones, David T.W., Pfister, Stefan M., Witt, Olaf

“…Abstract only LBA10503 Background: Several pediatric precision oncology programs have identified molecular actionable variants. However, the clinical benefit…”
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The potential of PARP as a therapeutic target across pediatric solid malignancies by Keller, Kaylee M, Koetsier, Joost, Schild, Linda, Amo-Addae, Vicky, Eising, Selma, van den Handel, Kim, Ober, Kimberley, Koopmans, Bianca, Essing, Anke, van den Boogaard, Marlinde L, Langenberg, Karin P S, Jäger, Natalie, Kool, Marcel, Pfister, Stefan, Dolman, M Emmy M, Molenaar, Jan J, van Hooff, Sander R

“…Pediatric cancer is the leading cause of disease-related death in children and the need for better therapeutic options remains urgent. Due to the limited…”
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Abstract PR004: Next generation pediatric precision oncology: Functional profiling of patient-derived viable tumor material to link genotype and phenotype by Looze, Eleonora J., Mao, Jie, Peterziel, Heike, Boltjes, Arjan, Koopmans, Bianca, Koster, Jan, Kool, Marcel, Van Noesel, Max M., Witt, Olaf, Molenaar, Jan J., Oehme, Ina, Dolman, M. Emmy M., Langenberg, Karin P.S.

“…Background Pediatric precision medicine programs iTHER (The Netherlands), INFORM (international), and ZERO (Australia), report actionable molecular drug…”
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Myeloproliferative Neoplasm Driven by ETV6-ABL1 in an Adolescent with Recent History of Burkitt Leukemia by Renzi, Samuele, Algawahmed, Fatimah, Davidson, Scott, Langenberg, Karin P S, Fuligni, Fabio, Ali, Salah, Anderson, Nathaniel, Brunga, Ledia, Bartram, Jack, Abdelhaleem, Mohamed, Naqvi, Ahmed, Beimnet, Kassa, Schuh, Andre, Tierens, Anne, Malkin, David, Shlien, Adam, Shago, Mary, Villani, Anita

“…gene fusion is a rare genetic rearrangement in a variety of malignancies, including myeloproliferative neoplasms (MPN), acute lymphoblastic leukemia (ALL), and…”
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Case series on clinical applications of liquid biopsy in pediatric solid tumors: towards improved diagnostics and disease monitoring by Gelineau, Nina U, van Barneveld, Astrid, Samim, Atia, Van Zogchel, Lieke, Lak, Nathalie, Tas, Michelle L, Matser, Yvette, Mavinkurve-Groothuis, Annelies M C, van Grotel, Martine, Zsiros, Jószef, van Eijkelenburg, Natasha K A, Knops, Rutger R G, van Ewijk, Roelof, Langenberg, Karin P S, Krijger, Ronald De, Hiemcke-Jiwa, Laura S, Van Paemel, Ruben, Cornelli, Lotte, De Preter, Katleen, De Wilde, Bram, Van Der Schoot, Ellen, Tytgat, Godelieve

“…Solid tumors account for about 30% of all pediatric cancers. The diagnosis is typically based on histological and molecular analysis of a primary tumor biopsy…”
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Assessment of Cancer Predisposition Syndromes in a National Cohort of Children With a Neoplasm by Bakhuizen, Jette J, Hopman, Saskia M J, Bosscha, Machteld I, Dommering, Charlotte J, van den Heuvel-Eibrink, Marry M, Hol, Janna A, Kester, Lennart A, Koudijs, Marco J, Langenberg, Karin P S, Loeffen, Jan L C, van der Lugt, Jasper, Moll, Annette C, van Noesel, Max M, Smetsers, Stephanie E, de Vos-Kerkhof, Evelien, Merks, Johannes H M, Kuiper, Roland P, Jongmans, Marjolijn C J

“…To improve diagnostics of cancer predisposition syndromes (CPSs) in children with cancer, it is essential to evaluate the effect of CPS gene sequencing among…”
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Outcome of Children and Adolescents With Relapsed/Refractory/Progressive Malignancies Treated With Molecularly Informed Targeted Drugs in the Pediatric Precision Oncology Registry INFORM by Heipertz, Anna-Elisa, Pajtler, Kristian W, Pfaff, Elke, Schramm, Kathrin, Blattner-Johnson, Mirjam, Milde, Till, Jones, Barbara C, Zuliani, Cecilia, Hutter, Caroline, Lohi, Olli, Kattamis, Antonis, Dachowska-Kalwak, Iwona, Nilsson, Anna, Gerber, Nicolas U, Langenberg, Karin P S, Goemans, Bianca, Zwaan, C Michel, Molenaar, Jan J, Jäger, Natalie, Dirksen, Uta, Witt, Ruth, Pfister, Stefan M, Jones, David T W, Kopp-Schneider, Annette, Witt, Olaf, van Tilburg, Cornelis M

“…INFORM is an international pediatric precision oncology registry, prospectively collecting molecular and clinical data of children with recurrent, progressive,…”
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Tumor to normal single-cell mRNA comparisons reveal a pan-neuroblastoma cancer cell by Kildisiute, Gerda, Kholosy, Waleed M, Young, Matthew D, Roberts, Kenny, Elmentaite, Rasa, van Hooff, Sander R, Pacyna, Clarissa N, Khabirova, Eleonora, Piapi, Alice, Thevanesan, Christine, Bugallo-Blanco, Eva, Burke, Christina, Mamanova, Lira, Keller, Kaylee M, Langenberg-Ververgaert, Karin P S, Lijnzaad, Philip, Margaritis, Thanasis, Holstege, Frank C P, Tas, Michelle L, Wijnen, Marc H W A, van Noesel, Max M, Del Valle, Ignacio, Barone, Giuseppe, van der Linden, Reinier, Duncan, Catriona, Anderson, John, Achermann, John C, Haniffa, Muzlifah, Teichmann, Sarah A, Rampling, Dyanne, Sebire, Neil J, He, Xiaoling, de Krijger, Ronald R, Barker, Roger A, Meyer, Kerstin B, Bayraktar, Omer, Straathof, Karin, Molenaar, Jan J, Behjati, Sam

“…Neuroblastoma is a childhood cancer that resembles developmental stages of the neural crest. It is not established what developmental processes neuroblastoma…”
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MYCN Amplified Relapse Following Resolution of MYCN Nonamplified 4S Neuroblastoma With Placental Involvement: A Case Report and Review of the Literature by Langenberg-Ververgaert, Karin P S, Renzi, Samuele, Chung, Catherine T, Shago, Mary, Lo, Winnie, Davidson, Scott, Villani, Anita, Baruchel, Sylvain, Irwin, Meredith S, Morgenstern, Daniel A

“…Congenital neuroblastoma with placental involvement is exceptionally rare, but mortality is high. Detailed examination of placenta including MYCN amplification…”
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Chemotherapy-Colchicine Interaction in a Child with Familial Mediterranean Fever and Hodgkin Lymphoma by Langenberg-Ververgaert, Karin P S, Laxer, Ronald M, Punnett, Angela S, Dupuis, L Lee, Finkelstein, Yaron, Abla, Oussama

“…Familial Mediterranean fever (FMF) has been associated with hematological malignancies but has not been reported in association with Hodgkin lymphoma (HL). We…”
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