Search Results - "Langel, Ulo"

Cell-penetrating peptides in protein mimicry and cancer therapeutics by Zorko, Matjaž, Jones, Sarah, Langel, Ülo

“…[Display omitted] Extensive research has been undertaken in the pursuit of anticancer therapeutics. Many anticancer drugs require specificity of delivery to…”
Get full text

Carbonized chitosan encapsulated hierarchical porous zeolitic imidazolate frameworks nanoparticles for gene delivery by Abdelhamid, Hani Nasser, Dowaidar, Moataz, Langel, Ülo

“…Hierarchical mesoporous carbon (MPC) nanomaterials derived from the carbonized chitosan (CTS) encapsulated zeolitic imidazolate frameworks (ZIF-8) is…”
Get full text

Recent CPP-based applications in medicine by Kurrikoff, Kaido, Langel, Ülo

“…: Cell-penetrating peptides (CPP) offer versatile tools for the field of drug delivery and development of macromolecular therapeutics. These tools have matured…”
Get more information

The future of peptides in cancer treatment by Kurrikoff, Kaido, Aphkhazava, David, Langel, Ülo

“…•Peptides from three distinct groups are important for cancer therapy and diagnostics.•Anticancer peptides are most frequently mimics of natural proteins and…”
Get full text

Gene delivery using cell penetrating peptides-zeolitic imidazolate frameworks by Abdelhamid, Hani Nasser, Dowaidar, Moataz, Hällbrink, Mattias, Langel, Ülo

“…Cell-penetrating peptides (CPPs), and metal-organic frameworks (MOFs) are promising as next-generation for the delivery of gene-based therapeutic agents…”
Get full text

Recent in vivo advances in cell-penetrating peptide-assisted drug delivery by Kurrikoff, Kaido, Gestin, Maxime, Langel, Ülo

“…Delivery of macromolecular drugs is an important field in medical research. However, macromolecules are usually unable to cross the cell membrane without the…”
Get more information

Novel cell‐penetrating peptide targeting mitochondria by Cerrato, Carmine Pasquale, Pirisinu, Marco, Vlachos, Efstathios Nikolaos, Langel, Ülo

“…ABSTRACT Cell‐penetrating peptides (CPPs) are short, nontoxic peptides with cationic and/or amphipathic properties able to cross the cellular membrane. CPPs…”
Get full text

Graphene oxide nanosheets in complex with cell penetrating peptides for oligonucleotides delivery by Dowaidar, Moataz, Abdelhamid, Hani Nasser, Hällbrink, Mattias, Zou, Xiaodong, Langel, Ülo

“…A new strategy for gene transfection using the nanocarrier of cell penetrating peptides (CPPs; PepFect14 (PF14) or PepFect14 (PF14) (PF221)) in complex with…”
Get full text

Cell-penetrating peptides for the delivery of nucleic acids by Lehto, Taavi, Kurrikoff, Kaido, Langel, Ülo

“…Different gene therapy approaches have gained extensive interest lately and, after many initial hurdles, several promising approaches have reached to the…”
Get more information

Synthesis of NickFects, a New Family of CPPs, by Solid-Phase Peptide Synthesis by Arukuusk, Piret, Langel, Ülo

“…Cell-penetrating peptides (CPPs) are relatively short peptides that can enter to the cell interior and facilitate intracellular delivery of associated cargo…”
Get more information

An update on cell-penetrating peptides with intracellular organelle targeting by Cerrato, Carmine Pasquale, Langel, Ülo

“…Cell-penetrating peptide (CPP) technologies represent an important strategy to address drug delivery to specific intracellular compartments by covalent…”
Get more information

Cell-penetrating peptides with intracellular organelle targeting by Cerrato, Carmine Pasquale, Künnapuu, Kadri, Langel, Ülo

“…One of the major limiting steps in order to have an effective drug is the passage through one or more cell membranes to reach its site of action. To reach the…”
Get more information

Uptake Mechanism of Cell-Penetrating Peptides by Gestin, Maxime, Dowaidar, Moataz, Langel, Ülo

“…Cell-penetrating peptides have been extensively used since their discovery for delivering cargoes unable to cross the cell membrane. Among other transported…”
Get more information

Chitosan enhances gene delivery of oligonucleotide complexes with magnetic nanoparticles–cell-penetrating peptide by Dowaidar, Moataz, Nasser Abdelhamid, Hani, Hällbrink, Mattias, Langel, Ülo, Zou, Xiaodong

“…Gene-based therapies, including the delivery of oligonucleotides, offer promising methods for the treatment of cancer cells. However, they have various…”
Get full text

Predicting cell-penetrating peptides by Hansen, Mats, Kilk, Kalle, Langel, Ülo

“…Possibility to predict short peptide sequences capable to penetrate the plasma membrane opens new opportunities for developing peptide based intracellular…”
Get full text

Cell‐penetrating peptides recruit type A scavenger receptors to the plasma membrane for cellular delivery of nucleic acids by Juks, Carmen, Lorents, Annely, Arukuusk, Piret, Langel, Ülo, Pooga, Margus

“…ABSTRACT Scavenger receptors (SRs) are a large family of multifunctional receptors that are involved in a range of physiologic and pathologic processes. The…”
Get full text

Classes of Cell-Penetrating Peptides by Pooga, Margus, Langel, Ülo

“…During the three decades of cell-penetrating peptides era the superfamily of CPPs has rapidly expanded, and the quest for new sequences continues. CPPs have…”
Get more information

Cell-penetrating peptides as vectors for peptide, protein and oligonucleotide delivery by MAE, M, LANGEL, U

“…High molecular weight biomolecules are becoming more and more important in the development of new therapeutic drugs. However, the hydrophilic nature of such…”
Get full text

Mimicry of Dopamine 1 Receptor Signaling with Cell-Penetrating Peptides by Lorenzon, Nicola, Gestin, Maxime, Langel, Ülo

“…In this study, through the use of protein mimicry, a peptide was developed to activate the dopamine 1 receptor signaling pathway from the inside of the cell…”
Get full text

Optimized luciferase assay for cell-penetrating peptide-mediated delivery of short oligonucleotides by Helmfors, Henrik, Eriksson, Jonas, Langel, Ülo

“…An improved assay for screening for the intracellular delivery efficacy of short oligonucleotides using cell-penetrating peptides is suggested. This assay is…”
Get full text