Search Results - "Langefeld, C.D."

The APOL1 Gene and Allograft Survival after Kidney Transplantation by Reeves‐Daniel, A. M., DePalma, J. A., Bleyer, A. J., Rocco, M. V., Murea, M., Adams, P. L., Langefeld, C. D., Bowden, D. W., Hicks, P. J., Stratta, R. J., Lin, J.‐J., Kiger, D. F., Gautreaux, M. D., Divers, J., Freedman, B. I.

“…Coding variants in the apolipoprotein L1 gene (APOL1) are strongly associated with nephropathy in African Americans (AAs). The effect of transplanting kidneys…”
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Diversity of risk alleles for SLE in African–American, European and Hispanic-American samples with those in Indian individuals by Graham, D.S. Cunninghame, Kelly, J.A, Langefeld, C.D, Graham, R.R, Gaffney, P.M, Vyse, T.J

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Genome wide and candidate gene studies of African American type 2 diabetes by Bowden, D.W, Allred, N.P, Langefeld, C.D, Divers, J, Freedman, B.I, Ng, M.C.Y

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Apolipoprotein L1 Gene Variants in Deceased Organ Donors Are Associated With Renal Allograft Failure by Freedman, B. I., Julian, B. A., Pastan, S. O., Israni, A. K., Schladt, D., Gautreaux, M. D., Hauptfeld, V., Bray, R. A., Gebel, H. M., Kirk, A. D., Gaston, R. S., Rogers, J., Farney, A. C., Orlando, G., Stratta, R. J., Mohan, S., Ma, L., Langefeld, C. D., Hicks, P. J., Palmer, N. D., Adams, P. L., Palanisamy, A., Reeves‐Daniel, A. M., Divers, J.

“…Apolipoprotein L1 gene (APOL1) nephropathy variants in African American deceased kidney donors were associated with shorter renal allograft survival in a prior…”
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GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region by Armstrong, D L, Zidovetzki, R, Alarcón-Riquelme, M E, Tsao, B P, Criswell, L A, Kimberly, R P, Harley, J B, Sivils, K L, Vyse, T J, Gaffney, P M, Langefeld, C D, Jacob, C O

“…In a genome-wide association study (GWAS) of individuals of European ancestry afflicted with systemic lupus erythematosus (SLE) the extensive utilization of…”
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Salivary dysbiosis and the clinical spectrum in anti-Ro positive mothers of children with neonatal lupus by Clancy, R.M., Marion, M.C., Ainsworth, H.C., Blaser, M.J., Chang, M., Howard, T.D., Izmirly, P.M., Lacher, C., Masson, M., Robins, K., Buyon, J.P., Langefeld, C.D.

“…Mothers giving birth to children with manifestations of neonatal lupus (NL) represent a unique population at risk for the development of clinically evident…”
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MHC associations with clinical and autoantibody manifestations in European SLE by Morris, D L, Fernando, M M A, Taylor, K E, Chung, S A, Nititham, J, Alarcón-Riquelme, M E, Barcellos, L F, Behrens, T W, Cotsapas, C, Gaffney, P M, Graham, R R, Pons-Estel, B A, Gregersen, P K, Harley, J B, Hauser, S L, Hom, G, Langefeld, C D, Noble, J A, Rioux, J D, Seldin, M F, Vyse, T J, Criswell, L A

“…Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease affecting multiple organ systems and characterized by autoantibody formation to…”
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Genetic analysis of the pathogenic molecular sub-phenotype interferon-alpha identifies multiple novel loci involved in systemic lupus erythematosus by Kariuki, S N, Ghodke-Puranik, Y, Dorschner, J M, Chrabot, B S, Kelly, J A, Tsao, B P, Kimberly, R P, Alarcón-Riquelme, M E, Jacob, C O, Criswell, L A, Sivils, K L, Langefeld, C D, Harley, J B, Skol, A D, Niewold, T B

“…Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by inflammation of multiple organ systems and dysregulated interferon…”
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Adiponectin as a novel determinant of bone mineral density and visceral fat by Lenchik, L, Register, T.C, Hsu, F-C, Lohman, K, Nicklas, B.J, Freedman, B.I, Langefeld, C.D, Carr, J.J, Bowden, D.W

“…Growing evidence suggests that positive associations between fat mass (FM) and bone mineral density (BMD) are mediated by not only biomechanical but also…”
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Implication of European-derived adiposity loci in African Americans by Hester, J M, Wing, M R, Li, J, Palmer, N D, Xu, J, Hicks, P J, Roh, B H, Norris, J M, Wagenknecht, L E, Langefeld, C D, Freedman, B I, Bowden, D W, Ng, M C Y

“…Objective: Recent genome-wide association studies (GWAS) have identified multiple novel loci associated with adiposity in European-derived study populations…”
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Genetic association of CD247 (CD3ζ) with SLE in a large-scale multiethnic study by Martins, M, Williams, A H, Comeau, M, Marion, M, Ziegler, J T, Freedman, B I, Merrill, J T, Glenn, S B, Kelly, J A, Sivils, K M, James, J A, Guthridge, J M, Alarcón-Riquelme, M E, Bae, S-C, Kim, J-H, Kim, D, Anaya, J-M, Boackle, S A, Criswell, L A, Kimberly, R P, Alarcón, G S, Brown, E E, Vilá, L M, Petri, M A, Ramsey-Goldman, R, Niewold, T B, Tsao, B P, Gilkeson, G S, Kamen, D L, Jacob, C O, Stevens, A M, Gaffney, P M, Harley, J B, Langefeld, C D, Fesel, C

“…A classic T-cell phenotype in systemic lupus erythematosus (SLE) is the downregulation and replacement of the CD3ζ chain that alters T-cell receptor signaling…”
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Variants in Intron 13 of the ELMO1 Gene are Associated with Diabetic Nephropathy in African Americans by Leak, T. S., Perlegas, P. S., Smith, S. G., Keene, K. L., Hicks, P. J., Langefeld, C. D., Mychaleckyj, J. C., Rich, S. S., Kirk, J. K., Freedman, B. I., Bowden, D. W., Sale, M. M.

“…Summary Variants in the engulfment and cell motility 1 (ELMO1) gene are associated with nephropathy due to type 2 diabetes mellitus (T2DM) in a Japanese…”
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Analysis of FTO gene variants with obesity and glucose homeostasis measures in the multiethnic Insulin Resistance Atherosclerosis Study cohort by WIng, M.R, Ziegler, J.M, Langefeld, C.D, Roh, B.H, Palmer, N.D, Mayer-Davis, E.J, Rewers, M.J, Haffner, S.M, Wagenknecht, L.E, Bowden, D.W

“…Objective: Previous studies have replicated the association of variants within FTO (fat mass- and obesity-associated) intron 1 with obesity and adiposity…”
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Interferon regulatory factor-5 is genetically associated with systemic lupus erythematosus in African Americans by Kelly, J A, Kelley, J M, Kaufman, K M, Kilpatrick, J, Bruner, G R, Merrill, J T, James, J A, Frank, S G, Reams, E, Brown, E E, Gibson, A W, Marion, M C, Langefeld, C D, Li, Q-Z, Karp, D R, Wakeland, E K, Petri, M, Ramsey-Goldman, R, Reveille, J D, Vilá, L M, Alarcón, G S, Kimberly, R P, Harley, J B, Edberg, J C

“…Increased expression of interferon (IFN)-inducible genes is implicated in the pathogenesis of systemic lupus erythematosus (SLE). One transcription factor…”
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Response to Mechanism of Action of APOL1 in Renal Allograft Survival (and Native CKD) Remains Unclear by Reeves‐Daniel, A. M., Divers, J., Langefeld, C. D., Freedman, B. I.

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Heterogeneity in gene loci associated with type 2 diabetes on human chromosome 20q13.1 by Bento, J.L., Palmer, N.D., Zhong, M., Roh, B., Lewis, J.P., Wing, M.R., Pandya, H., Freedman, B.I., Langefeld, C.D., Rich, S.S., Bowden, D.W., Mychaleckyj, J.C.

“…Human chromosome 20q12-q13.1 has been linked to type 2 diabetes mellitus (T2DM) in multiple studies. We screened a 5.795-Mb region for diabetes-related…”
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Evaluation of C1q genomic region in minority racial groups of lupus by Namjou, B, Gray-McGuire, C, Sestak, A L, Gilkeson, G S, Jacob, C O, Merrill, J T, James, J A, Wakeland, E K, Li, Q-Z, Langefeld, C D, Divers, J, Ziegler, J, Moser, K L, Kelly, J A, Kaufman, K M, Harley, J B

“…Complement cascade plasma proteins play a complex role in the etiopathogenesis of systemic lupus erythematosus (SLE). Hereditary C1q deficiency has been…”
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Identification of new SLE-associated genes with a two-step Bayesian study design by Armstrong, D L, Reiff, A, Myones, B L, Quismorio, F P, Klein-Gitelman, M, McCurdy, D, Wagner-Weiner, L, Silverman, E, Ojwang, J O, Kaufman, K M, Kelly, J A, Merrill, J T, Harley, J B, Bae, S-C, Vyse, T J, Gilkeson, G S, Gaffney, P M, Moser, K L, Putterman, C, Edberg, J C, Brown, E E, Ziegler, J, Langefeld, C D, Zidovetzki, R, Jacob, C O

“…In our earlier study, we utilized a Bayesian design to probe the association of ∼1000 genes (∼10 000 single-nucleotide polymorphisms (SNPs)) with systemic…”
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Replication of the BANK1 genetic association with systemic lupus erythematosus in a European-derived population by Guo, L, Deshmukh, H, Lu, R, Vidal, G S, Kelly, J A, Kaufman, K M, Dominguez, N, Klein, W, Kim-Howard, X, Bruner, G R, Scofield, R H, Moser, K L, Gaffney, P M, Dozmorov, I M, Gilkeson, G S, Wakeland, E K, Li, Q-Z, Langefeld, C D, Marion, M C, Williams, A H, Divers, J, Alarcón, G S, Brown, E E, Kimberly, R P, Edberg, J C, Ramsey-Goldman, R, Reveille, J D, McGwin, G, Vilá, L M, Petri, M A, Vyse, T J, Merrill, J T, James, J A, Nath, S K, Harley, J B, Guthridge, J M

“…Systemic lupus erythematosus (SLE) is an autoimmune disease with highly variable clinical presentation. Patients suffer from immunological abnormalities that…”
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Complement receptor 2 polymorphisms associated with systemic lupus erythematosus modulate alternative splicing by Douglas, K B, Windels, D C, Zhao, J, Gadeliya, A V, Wu, H, Kaufman, K M, Harley, J B, Merrill, J, Kimberly, R P, Alarcón, G S, Brown, E E, Edberg, J C, Ramsey-Goldman, R, Petri, M, Reveille, J D, Vilá, L M, Gaffney, P M, James, J A, Moser, K L, Alarcón-Riquelme, M E, Vyse, T J, Gilkeson, G S, Jacob, C O, Ziegler, J T, Langefeld, C D, Ulgiati, D, Tsao, B P, Boackle, S A

“…Genetic factors influence susceptibility to systemic lupus erythematosus (SLE). A recent family-based analysis in Caucasian and Chinese populations provided…”
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