Search Results - "Lange, Mary S"

Apoptosis Has a Prolonged Role in the Neurodegeneration after Hypoxic Ischemia in the Newborn Rat by Nakajima, Wako, Ishida, Akira, Lange, Mary S, Gabrielson, Kathleen L, Wilson, Mary Ann, Martin, Lee J, Blue, Mary E, Johnston, Michael V

“…Birth asphyxia can cause moderate to severe brain injury. It is unclear to what degree apoptotic or necrotic mechanisms of cell death account for damage after…”
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Glutamate Excitotoxicity Mediates Neuronal Apoptosis After Hypothermic Circulatory Arrest by Tseng, Elaine E., MD, Brock, Malcolm V., MD, Lange, Mary S., MA, Troncoso, Juan C., MD, Blue, Mary E., PhD, Lowenstein, Charles J., MD, Johnston, Michael V., MD, Baumgartner, William A., MD

“…Background Prolonged hypothermic circulatory arrest results in neuronal cell death and neurologic injury. We have previously shown that hypothermic circulatory…”
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Alpha II-Spectrin Breakdown Products Serve as Novel Markers of Brain Injury Severity in a Canine Model of Hypothermic Circulatory Arrest by Weiss, Eric S., MD, MPH, Wang, Kevin K.W., PhD, Allen, Jeremiah G., MD, Blue, Mary E., PhD, Nwakanma, Lois U., MD, Liu, Ming Cheng, MD, Lange, Mary S., MA, Berrong, Jennifer, Wilson, Mary Ann, PhD, Gott, Vincent L., MD, Troncoso, Juan C., MD, Hayes, Ronald L., PhD, Johnston, Michael V., MD, Baumgartner, William A., MD

“…Background The development of specific biomarkers to aid in the diagnosis and prognosis of neuronal injury is of paramount importance in cardiac surgery. Alpha…”
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Transcriptional Profile of Brain Injury in Hypothermic Circulatory Arrest and Cardiopulmonary Bypass by Allen, Jeremiah G., MD, Weiss, Eric S., MD, Wilson, Mary Ann, PhD, Arnaoutakis, George J., MD, Blue, Mary E., PhD, Talbot, C. Conover, BA, Jie, Chunfa, PhD, Lange, Mary S., MA, Troncoso, Juan C., MD, Johnston, Michael V., MD, Baumgartner, William A., MD

“…Background Little is known about the molecular mechanisms of neurologic complications after hypothermic circulatory arrest (HCA) with cardiopulmonary bypass…”
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Prolonged suppression of brain nitric oxide synthase activity by 7-nitroindazole protects against cerebral hypoxic–ischemic injury in neonatal rat by Ishida, Akira, Trescher, William H., Lange, Mary S., Johnston, Michael V.

“…Nitric oxide mediates glutamate-induced excitotoxicity associated with cerebral hypoxia–ischemia through production in the brain by several isoforms of nitric…”
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Minocycline worsens hypoxic-ischemic brain injury in a neonatal mouse model by Tsuji, Masahiro, Wilson, Mary Ann, Lange, Mary S., Johnston, Michael V.

“…Hypoxic-ischemic encephalopathy (HIE) is a leading cause of mortality and morbidity during the perinatal period, and currently no therapeutic drug is…”
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Brain Injury in Canine Models of Cardiac Surgery by Blue, Mary E, Wilson, Mary Ann, Beaty, Claude A, George, Timothy J, Arnaoutakis, George J, Haggerty, Kara A, Jones, Melissa, Brawn, Jeffrey, Manmohan, Shaliza, Lange, Mary S, Johnston, Michael V, Baumgartner, William A, Troncoso, Juan C

“…ABSTRACTNeuropathology and neurologic impairment were characterized in a clinically relevant canine model of hypothermic (18°C) circulatory arrest (HCA) and…”
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Protective effect of erythropoietin in neonatal hypoxic ischemia in mice by Matsushita, Hiroko, Johnston, Michael V, Lange, Mary S, Wilson, Mary Ann

“…The effect of systemic erythropoietin pretreatment on hypoxic ischemic injury was examined in neonatal mice. Injury was significantly less in cortex,…”
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Valproic Acid Prevents Brain Injury in a Canine Model of Hypothermic Circulatory Arrest: A Promising New Approach to Neuroprotection During Cardiac Surgery by Williams, Jason A., Barreiro, Christopher J., Nwakanma, Lois U., Lange, Mary S., Kratz, Lisa E., Blue, Mary E., Berrong, Jennifer, Patel, Nishant D., Gott, Vincent L., Troncoso, Juan C., Johnston, Michael V., Baumgartner, William A.

“…The anticonvulsant valproic acid (sodium valproate, Depacon™) acts as a neuroprotectant in rodents, but has never been tested in larger animals. We used…”
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Noninvasive Assessment of Brain Injury in a Canine Model of Hypothermic Circulatory Arrest Using Magnetic Resonance Spectroscopy by Barreiro, Christopher J., Williams, Jason A., Fitton, Torin P., Lange, Mary S., Blue, Mary E., Kratz, Lisa, Barker, Peter B., Degaonkar, Mahaveer, Gott, Vincent L., Troncoso, Juan C., Johnston, Michael V., Baumgartner, William A.

“…Studies have confirmed the neuroprotective effect of diazoxide in canines undergoing hypothermic circulatory arrest (HCA). A decreased…”
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Delayed Increase in Neuronal Nitric Oxide Synthase Immunoreactivity in Thalamus and Other Brain Regions after Hypoxic–Ischemic Injury in Neonatal Rats by Ishida, Akira, Ishiwa, Shun, Trescher, William H., Nakajima, Wako, Lange, Mary S., Blue, Mary E., Johnston, Michael V.

“…We examined the response of neuronal nitric oxide synthase (nNOS)-containing CNS neurons in rats exposed to a unilateral hypoxic–ischemic insult at 7 days of…”
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Neuronal Nitric Oxide Synthase Inhibition Reduces Neuronal Apoptosis After Hypothermic Circulatory Arrest by Tseng, Elaine E, Brock, Malcolm V, Lange, Mary S, Blue, Mary E, Troncoso, Juan C, Kwon, Christopher C, Lowenstein, Charles J, Johnston, Michael V, Baumgartner, William A

“…Background. Neurologic injury, including choreoathetosis and learning and memory deficits, occurs after prolonged hypothermic circulatory arrest (HCA)…”
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Increased intracerebral excitatory amino acids and nitric oxide after hypothermic circulatory arrest by Tseng, Elaine E, Brock, Malcolm V, Kwon, Christopher C, Annanata, Madhu, Lange, Mary S, Troncoso, Juan C, Johnston, Michael V, Baumgartner, William A

“…Background. Prolonged hypothermic circulatory arrest (HCA) results in neurologic injury, but the mechanism of this injury is unknown. This study was undertaken…”
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Nitric oxide mediates neurologic injury after hypothermic circulatory arrest by Tseng, Elaine E, Brock, Malcolm V, Lange, Mary S, Troncoso, Juan C, Lowenstein, Charles J, Blue, Mary E, Johnston, Michael V, Baumgartner, William A

“…Background. Prolonged hypothermic circulatory arrest (HCA) causes neurologic injury. However, the mechanism of this injury is unknown. We hypothesized that HCA…”
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Induction of neuronal nitric oxide after hypothermic circulatory arrest by Brock, Malcolm V., Blue, Mary E., Lowenstein, Charles J., Northington, Frances A., Lange, Mary S., Johnston, Michael V., Baumgartner, William A.

“…Although hypothermic circulatory arrest (HCA) has become routine practice in cardiac surgery, it is associated with substantial neurotoxicity. We tested the…”
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Monosialoganglioside GM1 inhibits neurotoxicity after hypothermic circulatory arrest by Tseng, E E, Brock, M V, Lange, M S, Troncoso, J C, Blue, M E, Lowenstein, C J, Johnston, M V, Baumgartner, W A

“…Prolonged hypothermic circulatory arrest (HCA) causes clinical neurologic injury. This injury involves neuronal apoptosis, or programmed cell death. We have…”
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AMPA glutamate receptor antagonism reduces neurologic injury after hypothermic circulatory arrest by Mark Redmond, J., Zehr, Kenton J., Blue, Mary E., Lange, Mary S., Marc Gillinov, A., Troncoso, Juan C., Cameron, Duke E., Johnston, Michael V., Baumgartner, William A.

“…Pharmacologic inhibition of the N-methyl- d-aspartate (NMDA) glutamate receptor can reduce the neurologic injury associated with hypothermic circulatory…”
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Valproic acid prevents brain injury in a canine model of hypothermic circulatory arrest : A promising new approach to neuroprotection during cardiac surgery. Discussion by WILLIAMS, Jason A, BARREIRO, Christopher J, JOHNSTON, Michael V, BAUMGARTNER, William A, HAMMON, John W, WHEATLEY, Grayson H, KOUCHOUKOS, Nicholas T, KURLANSKY, Paul, NWAKANMA, Lois U, LANGE, Mary S, KRATZ, Lisa E, BLUE, Mary E, BERRONG, Jennifer, PATEL, Nishant D, GOTT, Vincent L, TRONCOSO, Juan C

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Hawley H. Seiler Resident Award. Transcriptional profile of brain injury in hypothermic circulatory arrest and cardiopulmonary bypass by Allen, Jeremiah G, Weiss, Eric S, Wilson, Mary Ann, Arnaoutakis, George J, Blue, Mary E, Talbot, Jr, C Conover, Jie, Chunfa, Lange, Mary S, Troncoso, Juan C, Johnston, Michael V, Baumgartner, William A

“…Little is known about the molecular mechanisms of neurologic complications after hypothermic circulatory arrest (HCA) with cardiopulmonary bypass (CPB). Canine…”
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Apoptosis Detection in Brain Using Low-Magnification Dark-Field Microscopy by Lange, Mary S., Johnston, Michael V., Tseng, Elaine E., Baumgartner, William A., Blue, Mary E.

“…Apoptosis or programmed cell death is a feature of normal brain development and a response to brain injury. Cells undergoing apoptosis have a characteristic…”
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