Search Results - "Lange, L A"

BMI loci and longitudinal BMI from adolescence to young adulthood in an ethnically diverse cohort by Graff, M, North, K E, Richardson, A S, Young, K L, Mazul, A L, Highland, H M, Mohlke, K L, Lange, L A, Lange, E M, Mullan Harris, K, Gordon-Larsen, P

“…Objective: The association of obesity susceptibility variants with change in body mass index (BMI) across the life course is not well understood. Subjects: In…”
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Polymorphisms in the VKORC1 gene are strongly associated with warfarin dosage requirements in patients receiving anticoagulation by Li, T, Lange, L A, Li, X, Susswein, L, Bryant, B, Malone, R, Lange, E M, Huang, T-Y, Stafford, D W, Evans, J P

“…Background: Warfarin is a mainstay of therapy for conditions associated with an increased risk of thromboembolic events. However, the use of this common agent…”
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Novel gene variants predict serum levels of the cytokines IL-18 and IL-1ra in older adults by Matteini, A.M., Li, J., Lange, E.M., Tanaka, T., Lange, L.A., Tracy, R.P., Wang, Y., Biggs, M.L., Arking, D.E., Fallin, M.D., Chakravarti, A., Psaty, B.M., Bandinelli, S., Ferrucci, L., Reiner, A.P., Walston, J.D.

“…•We proposed that gene variation predicts changes in IL-18 and IL-1ra serum levels.•We conducted a genome-wide association scan in prospective cohorts of older…”
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Moderate to vigorous physical activity interactions with genetic variants and body mass index in a large US ethnically diverse cohort by Richardson, A. S., North, K. E., Graff, M., Young, K. M., Mohlke, K. L., Lange, L. A., Lange, E. M., Harris, K. M., Gordon-Larsen, P.

“…Summary What is already known about this subject Genome‐Wide Association Studies have successfully identified numerous genetic loci that influence body mass…”
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The interaction between physical activity and obesity gene variants in association with BMI: Does the obesogenic environment matter? by Graff, M., Richardson, A.S., Young, K.L., Mazul, A.L., Highland, Heather, North, K.E., Mohlke, K.L., Lange, L.A., Lange, E.M., Harris, K.M., Gordon-Larsen, P.

“…Little is known about how obesity susceptibility single nucleotide polymorphisms (SNPs) interact with moderate to vigorous physical activity (MVPA) in relation…”
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Influence of SNPSNP interaction on BMI in European American adolescents: findings from the National Longitudinal Study of Adolescent Health by Young, K. L., Graff, M., North, K. E., Richardson, A. S., Bradfield, J. P., Grant, S. F. A., Lange, L. A., Lange, E. M., Harris, K. M., Gordon-Larsen, P.

“…Summary Background Adolescent obesity is predictive of future weight gain, obesity and adult onset severe obesity (body mass index [BMI] ≥40 kg m−2). Despite…”
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Screen time behaviours may interact with obesity genes, independent of physical activity, to influence adolescent BMI in an ethnically diverse cohort by Graff, M., North, K. E., Richardson, A. S., Young, K. M., Mohlke, K. L., Lange, L. A., Lange, E. M., Harris, K. M., Gordon-Larsen, P.

“…Summary Background There has been little investigation of gene‐by‐environment interactions related to sedentary behaviour, a risk factor for obesity defined as…”
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Estimation of genetic effects on BMI during adolescence in an ethnically diverse cohort: The National Longitudinal Study of Adolescent Health by Graff, M, North, K E, Mohlke, K L, Lange, L A, Luo, J, Harris, K M, Young, K L, Richardson, A S, Lange, E M, Gordon-Larsen, P

“…Objective: The contribution of genetic variants to body mass index (BMI) during adolescence across multiethnic samples is largely unknown. We selected genetic…”
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Association of adipose tissue deposition and beta-2 adrenergic receptor variants: the IRAS family study by LANGE, L. A, NORRIS, J. M, LANGEFELD, C. D, NICKLAS, B. J, WAGENKNECHT, L. E, SAAD, M. F, BOWDEN, D. W

“…Adipose tissue distribution (visceral vs subcutaneous) has been shown to be an important predictor of insulin resistance, diabetes and cardiovascular disease,…”
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Hyaluronan and the Hyaluronan Receptor RHAMM Promote Focal Adhesion Turnover and Transient Tyrosine Kinase Activity by Hall, Christine L., Wang, Chao, Lange, Laurie A., Turley, Eva A.

“…The molecular mechanisms whereby hyaluronan (HA) stimulates cell motility was investigated in a C-H-ras transformed 10T 1/2 fibroblast cell line (C3). A…”
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Associations of activated coagulation factor VII and factor VIIa‐antithrombin levels with genome‐wide polymorphisms and cardiovascular disease risk by Olson, N. C., Raffield, L. M., Lange, L. A., Lange, E. M., Longstreth, W. T., Chauhan, G., Debette, S., Seshadri, S., Reiner, A. P., Tracy, R. P.

“…Essentials Essentials A fraction of coagulation factor VII circulates in blood as an activated protease (FVIIa). We evaluated FVIIa and FVIIa‐antithrombin…”
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Is rs7566605, a SNP near INSIG2, associated with body mass in a randomized clinical trial of antipsychotics in schizophrenia? by Skelly, T, Pinheiro, A P, Lange, L A, Sullivan, P F

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Large trans-ethnic meta-analysis identifies AKR1C4 as a novel gene associated with age at menarche by Sarnowski, C, Cousminer, D L, Franceschini, N, Raffield, L M, Jia, G, Fernández-Rhodes, L, Grant, S F A, Hakonarson, H, Lange, L A, Long, J, Sofer, T, Tao, R, Wallace, R B, Wong, Q, Zirpoli, G, Boerwinkle, E, Bradfield, J P, Correa, A, Kooperberg, C L, North, K E, Palmer, J R, Zemel, B S, Zheng, W, Murabito, J M, Lunetta, K L

“…Does the expansion of genome-wide association studies (GWAS) to a broader range of ancestries improve the ability to identify and generalise variants…”
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Association between gestational diabetes mellitus exposure and childhood adiposity is not substantially explained by offspring genetic risk of obesity by Raghavan, S., Zhang, W., Yang, I. V., Lange, L. A., Lange, E. M., Fingerlin, T. E., Dabelea, D.

“…Aim To examine the extent to which offspring obesity‐associated genetic risk explains the association between gestational diabetes mellitus and childhood…”
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Determination of Variation of Stimulated Salivary Flow Rates by Ghezzi, E.M., Lange, L.A., Ship, J.A.

“…Salivary hypofunction is associated with oral and pharyngeal disorders and requires early diagnosis and intervention. Large variability in salivary flow rates…”
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Coagulation factor XII genetic variation, ex vivo thrombin generation, and stroke risk in the elderly: results from the Cardiovascular Health Study by Olson, N. C., Butenas, S., Lange, L. A., Lange, E. M., Cushman, M., Jenny, N. S., Walston, J., Souto, J. C., Soria, J. M., Chauhan, G., Debette, S., Longstreth, W. T., Seshadri, S., Reiner, A. P., Tracy, R. P.

“…Summary Background The relationships of thrombin generation (TG) with cardiovascular disease risk are underevaluated in population‐based cohorts. Objectives To…”
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Pharmacogenomics study of thiazide diuretics and QT interval in multi-ethnic populations: the cohorts for heart and aging research in genomic epidemiology by Seyerle, A A, Sitlani, C M, Noordam, R, Gogarten, S M, Li, J, Li, X, Evans, D S, Sun, F, Laaksonen, M A, Isaacs, A, Kristiansson, K, Highland, H M, Stewart, J D, Harris, T B, Trompet, S, Bis, J C, Peloso, G M, Brody, J A, Broer, L, Busch, E L, Duan, Q, Stilp, A M, O'Donnell, C J, Macfarlane, P W, Floyd, J S, Kors, J A, Lin, H J, Li-Gao, R, Sofer, T, Méndez-Giráldez, R, Cummings, S R, Heckbert, S R, Hofman, A, Ford, I, Li, Y, Launer, L J, Porthan, K, Newton-Cheh, C, Napier, M D, Kerr, K F, Reiner, A P, Rice, K M, Roach, J, Buckley, B M, Soliman, E Z, de Mutsert, R, Sotoodehnia, N, Uitterlinden, A G, North, K E, Lee, C R, Gudnason, V, Stürmer, T, Rosendaal, F R, Taylor, K D, Wiggins, K L, Wilson, J G, Chen, Y-DI, Kaplan, R C, Wilhelmsen, K, Cupples, L A, Salomaa, V, van Duijn, C, Jukema, J W, Liu, Y, Mook-Kanamori, D O, Lange, L A, Vasan, R S, Smith, A V, Stricker, B H, Laurie, C C, Rotter, J I, Whitsel, E A, Psaty, B M, Avery, C L

“…Thiazide diuretics, commonly used antihypertensives, may cause QT interval (QT) prolongation, a risk factor for highly fatal and difficult to predict…”
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Noninvasive evaluation of hand circulation before radial artery harvest for coronary artery bypass grafting by Starnes, Sandra L., Wolk, Seth W., Lampman, Richard M., Shanley, Charles J., Prager, Richard L., Kong, Bobby K., Fowler, Jennifer J., Page, Jeanne M., Babcock, Shelly L., Lange, Leslie A., Erlandson, Errol E., Whitehouse, Walter M.

“…Objective: Radial artery harvesting for coronary artery bypass may lead to digit ischemia if collateral hand circulation is inadequate. The modified Allen's…”
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Diabetes Mellitus Affects Response to Neoadjuvant Chemoradiotherapy in the Management of Rectal Cancer by Caudle, A. S., Kim, H. J., Tepper, J. E., O’Neil, B. H., Lange, L. A., Goldberg, R. M., Bernard, S. A., Calvo, B. F., Meyers, M. O.

“…Introduction Although diabetic patients with rectal cancer have poorer outcomes than their nondiabetic counterparts, few studies have looked at diabetics’…”
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Common hemostasis and inflammation gene variants and venous thrombosis in older adults from the Cardiovascular Health Study by REINER, A. P., LANGE, L. A., SMITH, N. L., ZAKAI, N. A., CUSHMAN, M., FOLSOM, A. R.

“…Background/Objectives: Age‐related changes in blood coagulation and fibrinolysis are associated with increased risk of thrombotic events. Inherited…”
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