Search Results - "Lange, Joshua"

ecDNA hubs drive cooperative intermolecular oncogene expression by Hung, King L., Yost, Kathryn E., Xie, Liangqi, Shi, Quanming, Helmsauer, Konstantin, Luebeck, Jens, Schöpflin, Robert, Lange, Joshua T., Chamorro González, Rocío, Weiser, Natasha E., Chen, Celine, Valieva, Maria E., Wong, Ivy Tsz-Lo, Wu, Sihan, Dehkordi, Siavash R., Duffy, Connor V., Kraft, Katerina, Tang, Jun, Belk, Julia A., Rose, John C., Corces, M. Ryan, Granja, Jeffrey M., Li, Rui, Rajkumar, Utkrisht, Friedlein, Jordan, Bagchi, Anindya, Satpathy, Ansuman T., Tjian, Robert, Mundlos, Stefan, Bafna, Vineet, Henssen, Anton G., Mischel, Paul S., Liu, Zhe, Chang, Howard Y.

“…Extrachromosomal DNA (ecDNA) is prevalent in human cancers and mediates high expression of oncogenes through gene amplification and altered gene regulation 1 …”
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AmpliconReconstructor integrates NGS and optical mapping to resolve the complex structures of focal amplifications by Luebeck, Jens, Coruh, Ceyda, Dehkordi, Siavash R., Lange, Joshua T., Turner, Kristen M., Deshpande, Viraj, Pai, Dave A., Zhang, Chao, Rajkumar, Utkrisht, Law, Julie A., Mischel, Paul S., Bafna, Vineet

“…Oncogene amplification, a major driver of cancer pathogenicity, is often mediated through focal amplification of genomic segments. Recent results implicate…”
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The evolutionary dynamics of extrachromosomal DNA in human cancers by Lange, Joshua T., Rose, John C., Chen, Celine Y., Pichugin, Yuriy, Xie, Liangqi, Tang, Jun, Hung, King L., Yost, Kathryn E., Shi, Quanming, Erb, Marcella L., Rajkumar, Utkrisht, Wu, Sihan, Taschner-Mandl, Sabine, Bernkopf, Marie, Swanton, Charles, Liu, Zhe, Huang, Weini, Chang, Howard Y., Bafna, Vineet, Henssen, Anton G., Werner, Benjamin, Mischel, Paul S.

“…Oncogene amplification on extrachromosomal DNA (ecDNA) is a common event, driving aggressive tumor growth, drug resistance and shorter survival. Currently, the…”
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MAIT cells activate dendritic cells to promote TFH cell differentiation and induce humoral immunity by Pankhurst, Theresa E., Buick, Kaitlin H., Lange, Joshua L., Marshall, Andrew J., Button, Kaileen R., Palmer, Olga R., Farrand, Kathryn J., Montgomerie, Isabelle, Bird, Thomas W., Mason, Ngarangi C., Kuang, Joanna, Compton, Benjamin J., Comoletti, Davide, Salio, Mariolina, Cerundolo, Vincenzo, Quiñones-Mateu, Miguel E., Painter, Gavin F., Hermans, Ian F., Connor, Lisa M.

“…Protective immune responses against respiratory pathogens, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza virus, are…”
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Coordinated inheritance of extrachromosomal DNAs in cancer cells by Hung, King L., Jones, Matthew G., Wong, Ivy Tsz-Lo, Curtis, Ellis J., Lange, Joshua T., He, Britney Jiayu, Luebeck, Jens, Schmargon, Rachel, Scanu, Elisa, Brückner, Lotte, Yan, Xiaowei, Li, Rui, Gnanasekar, Aditi, Chamorro González, Rocío, Belk, Julia A., Liu, Zhonglin, Melillo, Bruno, Bafna, Vineet, Dörr, Jan R., Werner, Benjamin, Huang, Weini, Cravatt, Benjamin F., Henssen, Anton G., Mischel, Paul S., Chang, Howard Y.

“…The chromosomal theory of inheritance dictates that genes on the same chromosome segregate together while genes on different chromosomes assort independently 1…”
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Alpha-Gal Syndrome: Involvement of Amblyomma americanum α-D-Galactosidase and β-1,4 Galactosyltransferase Enzymes in α-Gal Metabolism by Sharma, Surendra Raj, Crispell, Gary, Mohamed, Ahmed, Cox, Cameron, Lange, Joshua, Choudhary, Shailesh, Commins, Scott P, Karim, Shahid

“…Alpha-Gal Syndrome (AGS) is an IgE-mediated delayed-type hypersensitivity reaction to the oligosaccharide galactose-α-1, 3-galactose (α-gal) injected into…”
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T-cell immune responses following vaccination with mRNA BNT162b2 against SARS-CoV-2 in patients with chronic lymphocytic leukemia: results from a prospective open-label clinical trial by Blixt, Lisa, Wullimann, David, Aleman, Soo, Lundin, Jeanette, Chen, Puran, Gao, Yu, Cuapio, Angelica, Akber, Mira, Lange, Joshua, Rivera-Ballesteros, Olga, Buggert, Marcus, Ljunggren, Hans-Gustaf, Hansson, Lotta, Österborg, Anders

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MAIT cell compartment characteristics are associated with the immune response magnitude to the BNT162b2 mRNA anti-SARS-CoV-2 vaccine by Boulouis, Caroline, Kammann, Tobias, Cuapio, Angelica, Parrot, Tiphaine, Gao, Yu, Mouchtaridi, Elli, Wullimann, David, Lange, Joshua, Chen, Puran, Akber, Mira, Rivera Ballesteros, Olga, Muvva, Jagadeeswara Rao, Smith, C I Edvard, Vesterbacka, Jan, Kieri, Oscar, Nowak, Piotr, Bergman, Peter, Buggert, Marcus, Ljunggren, Hans-Gustaf, Aleman, Soo, Sandberg, Johan K

“…Mucosa-associated invariant T (MAIT) cells are unconventional T cells with innate-like capacity to rapidly respond to microbial infection via MR1-restricted…”
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Genomic characterization of patient-derived xenograft models established from fine needle aspirate biopsies of a primary pancreatic ductal adenocarcinoma and from patient-matched metastatic sites by Allaway, Robert J, Fischer, Dawn A, de Abreu, Francine B, Gardner, Timothy B, Gordon, Stuart R, Barth, Richard J, Colacchio, Thomas A, Wood, Matthew, Kacsoh, Balint Z, Bouley, Stephanie J, Cui, Jingxuan, Hamilton, Joanna, Choi, Jungbin A, Lange, Joshua T, Peterson, Jason D, Padmanabhan, Vijayalakshmi, Tomlinson, Craig R, Tsongalis, Gregory J, Suriawinata, Arief A, Greene, Casey S, Sanchez, Yolanda, Smith, Kerrington D

“…N-of-1 trials target actionable mutations, yet such approaches do not test genomically-informed therapies in patient tumor models prior to patient treatment…”
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Deciphering the evolutionary dynamics of extrachromosomal DNA in human cancer by Lange, Joshua T, Mischel, Paul S

“…Oncogenes commonly amplify on circular extrachromosomal DNA (ecDNA) molecules in cancer. We show that ecDNA shapes each of the foundational principles of…”
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Deciphering the evolutionary dynamics of extrachromosomal DNA in human cancer

“…Oncogenes commonly amplify on circular extrachromosomal DNA (ecDNA) molecules in cancer. We show that ecDNA shapes each of the foundational principles of…”
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Human mucosal tissue-resident memory T cells in health and disease by Lange, Joshua, Rivera-Ballesteros, Olga, Buggert, Marcus

“…Memory T cells are fundamental to maintain immune surveillance of the human body. During the past decade, it has become apparent that non-recirculating…”
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Rise of the Digitized Public Intellectual: Death of the Professor in the Network Neutral Internet Age by Lange, Joshua

“…The centralised discourse claiming ownership of ‘knowledge’ and ‘higher education’ seems to be declining as the decentralising discourse extolling open source…”
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Deciphering the ins and outs of SARS-CoV-2-specific T cells by Perez-Potti, André, Lange, Joshua, Buggert, Marcus

“…Comprehensive analysis of specific and cross-reactive SARS-CoV-2 epitopes reveals functional T cell responses against specific viral regions in essentially all…”
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Immunodeficiency syndromes differentially impact the functional profile of SARS-CoV-2-specific T cells elicited by mRNA vaccination by Gao, Yu, Cai, Curtis, Wullimann, David, Niessl, Julia, Rivera-Ballesteros, Olga, Chen, Puran, Lange, Joshua, Cuapio, Angelica, Blennow, Ola, Hansson, Lotta, Mielke, Stephan, Nowak, Piotr, Vesterbacka, Jan, Akber, Mira, Perez-Potti, Andre, Sekine, Takuya, Müller, Thomas R., Boulouis, Caroline, Kammann, Tobias, Parrot, Tiphaine, Muvva, Jagadeeswara Rao, Sobkowiak, Michal, Healy, Katie, Bogdanovic, Gordana, Muschiol, Sandra, Söderdahl, Gunnar, Österborg, Anders, Hellgren, Fredrika, Grifoni, Alba, Weiskopf, Daniela, Sette, Alessandro, Loré, Karin, Sällberg Chen, Margaret, Ljungman, Per, Sandberg, Johan K., Smith, C.I. Edvard, Bergman, Peter, Ljunggren, Hans-Gustaf, Aleman, Soo, Buggert, Marcus

“…Many immunocompromised patients mount suboptimal humoral immunity after SARS-CoV-2 mRNA vaccination. Here, we assessed the single-cell profile of…”
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Abstract 95: The landscape of extrachromosomal circular DNA in medulloblastoma subgroups by Chapman, Owen S., Wang, Shanqing, Luebeck, Jens, Garancher, Alexandra, Larson, Jon D., Lange, Joshua, Crawford, John, Pomeroy, Scott L., Mischel, Paul, Fraenkel, Ernest, Wechsler-Reya, Robert J., Bafna, Vineet, Mesirov, Jill P., Chavez, Lukas

“…Abstract Extrachromosomal circular DNA (ecDNA) has been shown to be an important driver of particularly aggressive human cancers. However, it remains unknown…”
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Cancer Being Extra: Extrachromosomal DNA Promotes Heterogeneity and Resistance in Cancer by Lange, Joshua T

“…In cancer, oncogenes are frequently amplified on extrachromosomal DNA (ecDNA), circular acentric DNA fragments ranging from hundreds of kilobases to multiple…”
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The Chemical Synthesis, Stability, and Activity of MAIT Cell Prodrug Agonists That Access MR1 in Recycling Endosomes by Lange, Joshua, Anderson, Regan J, Marshall, Andrew J, Chan, Susanna T. S, Bilbrough, Timothy S, Gasser, Olivier, Gonzalez-Lopez, Claudia, Salio, Mariolina, Cerundolo, Vincenzo, Hermans, Ian F, Painter, Gavin F

“…Mucosal-associated invariant T (MAIT) cells are antibacterial effector T cells that react to pyrimidines derived from bacterial riboflavin synthesis presented…”
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Identification of resident memory CD8 + T cells with functional specificity for SARS-CoV-2 in unexposed oropharyngeal lymphoid tissue by Niessl, Julia, Sekine, Takuya, Lange, Joshua, Konya, Viktoria, Forkel, Marianne, Maric, Jovana, Rao, Anna, Mazzurana, Luca, Kokkinou, Efthymia, Weigel, Whitney, Llewellyn-Lacey, Sian, Hodcroft, Emma B, Karlsson, Annika C, Fehrm, Johan, Sundman, Joar, Price, David A, Mjösberg, Jenny, Friberg, Danielle, Buggert, Marcus

“…Cross-reactive CD4 T cells that recognize severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are more commonly detected in the peripheral blood of…”
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Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma by Chapman, Owen S., Luebeck, Jens, Sridhar, Sunita, Wong, Ivy Tsz-Lo, Dixit, Deobrat, Wang, Shanqing, Prasad, Gino, Rajkumar, Utkrisht, Pagadala, Meghana S., Larson, Jon D., He, Britney Jiayu, Hung, King L., Lange, Joshua T., Dehkordi, Siavash R., Chandran, Sahaana, Adam, Miriam, Morgan, Ling, Wani, Sameena, Tiwari, Ashutosh, Guccione, Caitlin, Lin, Yingxi, Dutta, Aditi, Lo, Yan Yuen, Juarez, Edwin, Robinson, James T., Korshunov, Andrey, Michaels, John-Edward A., Cho, Yoon-Jae, Malicki, Denise M., Coufal, Nicole G., Levy, Michael L., Hobbs, Charlotte, Scheuermann, Richard H., Crawford, John R., Pomeroy, Scott L., Rich, Jeremy N., Zhang, Xinlian, Chang, Howard Y., Dixon, Jesse R., Bagchi, Anindya, Deshpande, Aniruddha J., Carter, Hannah, Fraenkel, Ernest, Mischel, Paul S., Wechsler-Reya, Robert J., Bafna, Vineet, Mesirov, Jill P., Chavez, Lukas

“…Circular extrachromosomal DNA (ecDNA) in patient tumors is an important driver of oncogenic gene expression, evolution of drug resistance and poor patient…”
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