Search Results - "Lange, Jeffrey"

Notch signalling drives synovial fibroblast identity and arthritis pathology by Wei, Kevin, Korsunsky, Ilya, Marshall, Jennifer L., Gao, Anqi, Watts, Gerald F. M., Major, Triin, Croft, Adam P., Watts, Jordan, Blazar, Philip E., Lange, Jeffrey K., Thornhill, Thomas S., Filer, Andrew, Raza, Karim, Donlin, Laura T., Siebel, Christian W., Buckley, Christopher D., Raychaudhuri, Soumya, Brenner, Michael B.

“…The synovium is a mesenchymal tissue composed mainly of fibroblasts, with a lining and sublining that surround the joints. In rheumatoid arthritis the synovial…”
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A suppressor of a wtf poison-antidote meiotic driver acts via mimicry of the driver's antidote by Bravo Núñez, María Angélica, Lange, Jeffrey J, Zanders, Sarah E

“…Meiotic drivers are selfish alleles that subvert gametogenesis to increase their transmission into progeny. Drivers impose a fitness cost, putting pressure on…”
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Dramatically diverse Schizosaccharomyces pombe wtf meiotic drivers all display high gamete-killing efficiency by Bravo Núñez, María Angélica, Sabbarini, Ibrahim M, Eickbush, Michael T, Liang, Yue, Lange, Jeffrey J, Kent, Aubrey M, Zanders, Sarah E

“…Meiotic drivers are selfish alleles that can force their transmission into more than 50% of the viable gametes made by heterozygotes. Meiotic drivers are known…”
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Satisfaction Rates and Quality of Life Changes Following Total Knee Arthroplasty in Age-Differentiated Cohorts by Lange, Jeffrey K., Lee, Yuo-Yu, Spiro, Sara K., Haas, Steven B.

“…Comparisons of satisfaction rates following total knee arthroplasty (TKA) among large, age-differentiated, rigorously matched cohorts are lacking. Therefore,…”
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Quantifying Nucleation In Vivo Reveals the Physical Basis of Prion-like Phase Behavior by Khan, Tarique, Kandola, Tejbir S., Wu, Jianzheng, Venkatesan, Shriram, Ketter, Ellen, Lange, Jeffrey J., Rodríguez Gama, Alejandro, Box, Andrew, Unruh, Jay R., Cook, Malcolm, Halfmann, Randal

“…Protein self-assemblies modulate protein activities over biological timescales that can exceed the lifetimes of the proteins or even the cells that harbor…”
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Anesthesia and Analgesia Practices in Total Joint Arthroplasty: A Survey of the American Association of Hip and Knee Surgeons Membership by Hannon, Charles P., Keating, Timothy C., Lange, Jeffrey K., Ricciardi, Benjamin F., Waddell, Bradford S., Della Valle, Craig J.

“…The purpose of this study is to survey the current analgesia and anesthesia practices used by total joint arthroplasty surgeon members of the American…”
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rRNA transcription is integral to phase separation and maintenance of nucleolar structure by Dash, Soma, Lamb, Maureen C, Lange, Jeffrey J, McKinney, Mary C, Tsuchiya, Dai, Guo, Fengli, Zhao, Xia, Corbin, Timothy J, Kirkman, MaryEllen, Delventhal, Kym, Moore, Emma L, McKinney, Sean, Shiang, Rita, Trainor, Paul A

“…Transcription of ribosomal RNA (rRNA) by RNA Polymerase (Pol) I in the nucleolus is necessary for ribosome biogenesis, which is intimately tied to cell growth…”
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Genome-wide quantification of contributions to sexual fitness identifies genes required for spore viability and health in fission yeast by Billmyre, R Blake, Eickbush, Michael T, Craig, Caroline J, Lange, Jeffrey J, Wood, Christopher, Helston, Rachel M, Zanders, Sarah E

“…Numerous genes required for sexual reproduction remain to be identified even in simple model species like Schizosaccharomyces pombe. To address this, we…”
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Dual-Mobility vs Fixed-Bearing Total Hip Arthroplasty in Patients Under 55 Years of Age: A Single-Institution, Matched-Cohort Analysis by Rowan, Fiachra E., MD, FRCS, Salvatore, Anthony J., MS, Lange, Jeffrey K., MD, Westrich, Geoffrey H., MD

“…Abstract Background Prosthetic dislocation of total hip arthroplasty (THA) is a common cause for revision surgery. Dual-mobility (DM) bearings were introduced…”
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Correlation Between Patient-Reported Outcome Measures and Health Insurance Provider Types in Patients with Hip Osteoarthritis by Greene, Brady D., Lange, Jeffrey K., Heng, Marilyn, Melnic, Christopher M., Smith, Jeremy T.

“…Background: Patient-reported outcome measures (PROMs) are frequently utilized to assess patient perceptions of health and function. Numerous factors influence…”
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Lola-I is a promoter pioneer factor that establishes de novo Pol II pausing during development by Ramalingam, Vivekanandan, Yu, Xinyang, Slaughter, Brian D., Unruh, Jay R., Brennan, Kaelan J., Onyshchenko, Anastasiia, Lange, Jeffrey J., Natarajan, Malini, Buck, Michael, Zeitlinger, Julia

“…While the accessibility of enhancers is dynamically regulated during development, promoters tend to be constitutively accessible and poised for activation by…”
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The disordered regions of the methyltransferase SETD2 govern its function by regulating its proteolysis and phase separation by Bhattacharya, Saikat, Lange, Jeffrey J., Levy, Michaella, Florens, Laurence, Washburn, Michael P., Workman, Jerry L.

“…SETD2 is an important methyltransferase that methylates crucial substrates such as histone H3, tubulin, and STAT1 and also physically interacts with…”
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Wnt and TGFβ coordinate growth and patterning to regulate size-dependent behaviour by Arnold, Christopher P., Benham-Pyle, Blair W., Lange, Jeffrey J., Wood, Christopher J., Sánchez Alvarado, Alejandro

“…Differential coordination of growth and patterning across metazoans gives rise to a diversity of sizes and shapes at tissue, organ and organismal levels…”
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Regulators of rDNA array morphology in fission yeast by Cockrell, Alexandria J, Lange, Jeffrey J, Wood, Christopher, Mattingly, Mark, McCroskey, Scott M, Bradford, William D, Conkright-Fincham, Juliana, Weems, Lauren, Guo, Monica S, Gerton, Jennifer L

“…Nucleolar morphology is a well-established indicator of ribosome biogenesis activity that has served as the foundation of many screens investigating ribosome…”
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Racial and Ethnic Minority Patients Have Increased Complication Risks When Undergoing Surgery While Not Meeting Clinical Guidelines by Liimakka, Adriana P, Amen, Troy B, Weaver, Michael J, Shah, Vivek M, Lange, Jeffrey K, Chen, Antonia F

“…Clinical guidelines for performing total joint arthroplasty (TJA) have not been uniformly adopted in practice because research has suggested that they may…”
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Hox genes regulate asexual reproductive behavior and tissue segmentation in adult animals by Arnold, Christopher P., Lozano, Analí Migueles, Mann, Frederick G., Nowotarski, Stephanie H., Haug, Julianna O., Lange, Jeffrey J., Seidel, Chris W., Alvarado, Alejandro Sánchez

“…Hox genes are highly conserved transcription factors renowned for their roles in the segmental patterning of the embryonic anterior-posterior (A/P) axis. We…”
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Mechanistic Inferences From Analysis of Measurements of Protein Phase Transitions in Live Cells by Posey, Ammon E., Ruff, Kiersten M., Lalmansingh, Jared M., Kandola, Tejbir S., Lange, Jeffrey J., Halfmann, Randal, Pappu, Rohit V.

“…[Display omitted] •Automated methods for classifying and analyzing protein phase transitions are needed.•DAmFRET is a high-throughput technique to study phase…”
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S. pombe wtf drivers use dual transcriptional regulation and selective protein exclusion from spores to cause meiotic drive by Nuckolls, Nicole L, Nidamangala Srinivasa, Ananya, Mok, Anthony C, Helston, Rachel M, Bravo Núñez, María Angélica, Lange, Jeffrey J, Gallagher, Todd J, Seidel, Chris W, Zanders, Sarah E

“…Meiotic drivers bias gametogenesis to ensure their transmission into more than half the offspring of a heterozygote. In Schizosaccharomyces pombe, wtf meiotic…”
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Are There More Radiolucent Lines in Patients Who Underwent Total Knee Arthroplasty With or Without a Tourniquet During Cementation at 5 to 8 Years After Surgery? by Xu, Haijun, Chen, Antonia F., Shoji, Monica M., Fitz, Wolfgang, Lange, Jeffrey K.

“…This study investigated the presence and progression of radiolucent lines (RLLs) after cemented total knee arthroplasty (TKA) with or without tourniquet use…”
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Patient-Specific Safe Zones for Acetabular Component Positioning in Total Hip Arthroplasty: Mathematically Accounting for Spinopelvic Biomechanics by Ramkumar, Prem N., Pang, Michael, Vigdorchik, Jonathan M., Chen, Antonia F., Iorio, Richard, Lange, Jeffrey K.

“…Despite a growing understanding of spinopelvic biomechanics in total hip arthroplasty (THA), there is no validated approach for executing patient-specific…”
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