Search Results - "Lange, Ingo"

A minimal regulatory domain in the C terminus of STIM1 binds to and activates ORAI1 CRAC channels by Kawasaki, Takumi, Lange, Ingo, Feske, Stefan

“…Store-operated Ca 2+ entry (SOCE) is a universal mechanism to increase intracellular Ca 2+ concentrations in non-excitable cells. It is initiated by the…”
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Protein Kinase C-induced Phosphorylation of Orai1 Regulates the Intracellular Ca2+ Level via the Store-operated Ca2+ Channel by Kawasaki, Takumi, Ueyama, Takehiko, Lange, Ingo, Feske, Stefan, Saito, Naoaki

“…Ca2+ signals through store-operated Ca2+ (SOC) channels, activated by the depletion of Ca2+ from the endoplasmic reticulum, regulate various physiological…”
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Dendritic cell maturation and chemotaxis is regulated by TRPM2‐mediated lysosomal Ca2+ release by Sumoza‐Toledo, Adriana, Lange, Ingo, Cortado, Hanna, Bhagat, Harivadan, Mori, Yasuo, Fleig, Andrea, Penner, Reinhold, Partida‐Sánchez, Santiago

“…ABSTRACT Chemokines induce calcium (Ca2+) signaling and chemotaxis in dendritic cells (DCs), but the molecular players involved in shaping intracellular Ca2+…”
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Assessing the weather conditions for urban cyclists by spatially dense measurements with an agent‐based approach by Schmitt, Amelie U., Burgemeister, Finn, Dorff, Henning, Finn, Tobias, Hansen, Akio, Kirsch, Bastian, Lange, Ingo, Radtke, Jule, Ament, Felix

“…Convincing commuters to use a bike is a timely contribution to reach sustainability goals. However, more than other modes of transportation, cycling is heavily…”
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STIM1 and STIM2 Mediate Cancer-Induced Inflammation in T Cell Acute Lymphoblastic Leukemia by Saint Fleur-Lominy, Shella, Maus, Mate, Vaeth, Martin, Lange, Ingo, Zee, Isabelle, Suh, David, Liu, Cynthia, Wu, Xiaojun, Tikhonova, Anastasia, Aifantis, Iannis, Feske, Stefan

“…T cell acute lymphoblastic leukemia (T-ALL) is commonly associated with activating mutations in the NOTCH1 pathway. Recent reports have shown a link between…”
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Atmospheric boundary layer measurements at the 280 m high Hamburg weather mast 1995-2011: mean annual and diurnal cycles by Burghard Brümmer, Ingo Lange, Heike Konow

“…In this paper, the 280 m high Hamburg weather mast and its instrumentation are introduced. Digital data recorded since 1995 are used to calculate the mean…”
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Dual Beneficial Effects of Methylnissolin-3-O-β-d-Glucopyranoside on Obesity-Induced Inflammatory Responses in Adipocyte-Macrophage Co-Culture by Lee, Dahae, Wu, Xiaohua, Lange, Ingo, Cao, Shugeng, Kang, Ki Sung

“…Methylnissolin-3-O-β-d-glucopyranoside (MNG) is a pterocarpan analog, which protects EA.hy926 cells against oxidative damage through the Nrf2/HO-1 pathway…”
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Synthesis and Characterization of Lipophilic Salts of Metformin to Improve Its Repurposing for Cancer Therapy by Saeed, Hiwa K, Sutar, Yogesh, Patel, Pratikkumar, Bhat, Roopal, Mallick, Sudipta, Hatada, Alyssa E, Koomoa, Dana-Lynn T, Lange, Ingo, Date, Abhijit A

“…Epidemiological evidence has accentuated the repurposing of metformin hydrochloride for cancer treatment. However, the extreme hydrophilicity and poor…”
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MycN promotes TRPM7 expression and cell migration in neuroblastoma through a process that involves polyamines by Lange, Ingo, Koomoa, Dana-Lynn T.

“…•MycN expression correlates with TRPM7 expression in neuroblastoma (NB) tumors.•Expression of the transmembrane protein TRPM7 correlates with lower overall…”
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DFMO/eflornithine inhibits migration and invasion downstream of MYCN and involves p27Kip1 activity in neuroblastoma by KOOMOA, DANA-LYNN T, GEERTS, DIRK, LANGE, INGO, KOSTER, JAN, PEGG, ANTHONY E, FEITH, DAVID J, BACHMANN, ANDRÉ S

“…Neuroblastoma (NB) is the most common extracranial pediatric tumor. NB patients over 18 months of age at the time of diagnosis are often in the later stages of…”
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TRPM2 functions as a lysosomal Ca2+-release channel in beta cells by Lange, Ingo, Yamamoto, Shinichiro, Partida-Sanchez, Santiago, Mori, Yasuo, Fleig, Andrea, Penner, Reinhold

“…TRPM2 is a Ca2+-permeable cation channel that is specifically activated by adenosine diphosphoribose (ADPR). Channel activation in the plasma membrane leads to…”
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In vitro efficacy of anthelmintics on Angiostrongylus cantonensis L3 larvae by Jacob, John, Tan, Ghee, Lange, Ingo, Saeed, Hiwa, Date, Abhijit, Jarvi, Susan

“…Angiostrongylus cantonensis is the leading cause of eosinophilic meningitis worldwide, with life-threatening complications if not managed correctly. Previous…”
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Calcium signaling regulates fundamental processes involved in Neuroblastoma progression by Lange, Ingo, Koster, Jan, Koomoa, Dana-Lynn T.

“…•This review focuses on the current understanding of the role of calcium signaling on the malignant progression of Neuroblastoma.•Few channels so far have been…”
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Abstract LB-68: MYCN-induced TRPM7 expression and channel activity occurs through a mechanism that involves ornithine decarboxylase by Koomoa, Dana-Lynn T., Lange, Ingo

“…Neuroblastoma (NB) is an extra-cranial solid cancer in children. MYCN is a transcription factor that regulates the expression of genes that are involved in…”
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Synergistic regulation of endogenous TRPM2 channels by adenine dinucleotides in primary human neutrophils by Lange, Ingo, Penner, Reinhold, Fleig, Andrea, Beck, Andreas

“…Summary The Ca2+ -permeable TRPM2 channel is a dual function protein that is activated by intracellular ADPR through its enzymatic pyrophosphatase domain with…”
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Abstract 3781: MYCN-induced TRPM7 mediates calcium influx and promotes neuroblastoma cell migration by Lange, Ingo, Koomoa, Dana-Lynn T.

“…Neuroblastoma (NB) is the most common extra-cranial solid cancer in children. One of the genetic characteristics of advanced stage NB is MYCN gene…”
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Potential anti-neuroblastoma agents from Juniperus oblonga by Qiao, Yilin, Sunada, Nathan K., Hatada, Alyssa E., Lange, Ingo, Khutsishvili, Manana, Alizade, Valida, Atha, Daniel, Ko'omoa-Lange, Dana-Lynn, Borris, Robert P.

“…Neuroblastoma (NB) is a neuroendocrine tumor derived from neural crest cells. Approximately 90% of cases occur in children less than 5 years old. The…”
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Novel Interaction of Ornithine Decarboxylase with Sepiapterin Reductase Regulates Neuroblastoma Cell Proliferation by Lange, Ingo, Geerts, Dirk, Feith, David J., Mocz, Gabor, Koster, Jan, Bachmann, André S.

“…Ornithine decarboxylase (ODC) is the sentinel enzyme in polyamine biosynthesis. Both ODC and polyamines regulate cell division, proliferation, and apoptosis…”
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FTY-720 induces apoptosis in neuroblastoma via multiple signaling pathways by Lange, Ingo, Espinoza-Fuenzalida, Italo, Ali, Mourad Wagdy, Serrano, Laura Espana, Koomoa, Dana-Lynn T

“…Neuroblastoma (NB) is the most common extra-cranial pediatric solid tumor. High-risk NB is difficult to treat due to the lack of response to current therapies…”
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TRPM2 ion channels regulate macrophage polarization and gastric inflammation during Helicobacter pylori infection by Beceiro, S, Radin, J N, Chatuvedi, R, Piazuelo, M B, Horvarth, D J, Cortado, H, Gu, Y, Dixon, B, Gu, C, Lange, I, Koomoa, D-LT, Wilson, K T, Algood, H M S, Partida-Sánchez, S

“…Calcium signaling in phagocytes is essential for cellular activation, migration, and the potential resolution of infection or inflammation. The generation of…”
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