Search Results - "Lange, Herwig W."

Grasping premanifest Huntington's disease - shaping new endpoints for new trials by Reilmann, Ralf, Bohlen, Stefan, Klopstock, Thomas, Bender, Andreas, Weindl, Adolf, Saemann, Philipp, Auer, Dorothee P., Ringelstein, Erich B., Lange, Herwig W.

“…Future clinical trials in subjects with premanifest Huntington's disease (preHD) may depend on the availability of biomarkers. It was previously shown in…”
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Tongue force analysis assesses motor phenotype in premanifest and symptomatic Huntington's disease by Reilmann, Ralf, Bohlen, Stefan, Klopstock, Thomas, Bender, Andreas, Weindl, Adolf, Saemann, Philipp, Auer, Dorothee P., Ringelstein, E. Bernd, Lange, Herwig W.

“…Motor symptoms in Huntington's Disease (HD) are commonly assessed by the Unified Huntington's Disease Rating Scale‐Total Motor Score (UHDRS‐TMS). However, the…”
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Assessment of involuntary choreatic movements in Huntington's disease-Toward objective and quantitative measures by Reilmann, Ralf, Bohlen, Stefan, Kirsten, Florian, Ringelstein, E. Bernd, Lange, Herwig W.

“…Objective measures of motor impairment may improve the sensitivity and reliability of motor end points in clinical trials. In Huntington's disease, involuntary…”
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Huntington's Disease (HD): Neurodegeneration of Brodmann's Primary Visual Area 17 (BA17) by Rüb, Udo, Seidel, Kay, Vonsattel, Jean Paul, Lange, Herwig W., Eisenmenger, Wolfgang, Götz, Monika, Del Turco, Domenico, Bouzrou, Mohamed, Korf, Horst-Werner, Heinsen, Helmut

“…Huntington's disease (HD), an autosomal dominantly inherited polyglutamine or CAG repeat disease along with somatomotor, oculomotor, psychiatric and cognitive…”
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Huntington's disease: Objective assessment of posture-A link between motor and functional deficits by Reilmann, Ralf, Rumpf, Silke, Beckmann, Heike, Koch, Raphael, Ringelstein, Erich B., Lange, Herwig W.

“…Background: Postural deficits in Huntington's disease are linked to functional impairment. We investigated whether assessment of center‐of‐mass variability…”
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Genetic analysis of candidate genes modifying the age-at-onset in Huntington's disease by METZGER, Silke, BAUER, Peter, SEPPI, Klaus, MELEGH, Bela, HAVASI, Viktoria, BALIKO, Laszlo, WIECZOREK, Stefan, ZAREMBA, Jacek, HOFFMAN-ZACHARSKA, Dorota, SULEK, Anna, NAZLI BASAK, A, SOYDAN, Esra, TOMIUK, Jürgen, ZIDOVSKA, Jana, KEBRDLOVA, Vera, PANDOLFO, Massimo, RIBÏ, Pascale, KADASI, Ludovit, KVASNICOVA, Marta, WEBER, Bernhard H. F, KREUZ, Friedmar, DOSE, Matthias, STUHRMANN, Manfred, LACCONE, Franco, RIESS, Olaf, DIDONATO, Stefano, GELLERA, Cinzia, MARIOTTI, Caterina, LANGE, Herwig W, WEIRICH-SCHWAIGER, Helga, WENNING, Gregor K

“…The expansion of a polymorphic CAG repeat in the HD gene encoding huntingtin has been identified as the major cause of Huntington's disease (HD) and determines…”
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Velocity modulation and rhythmic synchronization of gait in Huntington's disease by Thaut, Michael H., Miltner, Rgina, Lange, Herwig W., Hurt, Corene P., Hoemberg, Volker

“…This study analyzed the ability of patients with Huntington's disease (HD) to modulate gait velocity without external sensory cues and in response to an…”
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Differential effect of Huntington's and Parkinson's diseases in programming motor sequences of varied lengths by YAGÜEZ, Lidia, LANGE, Herwig W, HÖMBERG, Volker

“…Parkinson's disease (PD) and Huntington's disease (HD) patients have difficulties executing sequential movements. Attention control and short-term memory…”
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The S18Y polymorphism in the UCHL1 gene is a genetic modifier in Huntington's disease by METZGER, Silke, BAIUER, Peter, MELEGH, Bela, HAVASI, Victoria, BALIKO, Lazlo, WIECZOREK, Stefan, ARNING, Larissa, ZAREMBA, Jacek, SUIEK, Anna, HOFFMAN-ZACHARSKA, Dorota, BASAK, A. Nazli, ERSOY, Nagehan, TOMIUK, Juergen, ZIDOVSKA, Jana, KEBRDLOVA, Vera, PANDOLFO, Massimo, RIBAÏ, Pascale, KADASI, Ludovit, KVASNICOVA, Marta, WEBER, Bernhard H. F, KREUZ, Friedmar, DOSE, Matthias, STUHRMANN, Manfred, LACCONE, Franco, RIESS, Olaf, DIDONATO, Stefano, GELLERA, Cinzia, SOLIVERI, Paola, LANGE, Herwig W, WEIRICH-SCHWAIGER, Helga, WENNING, Gregor K

“…An expanded polyglutamine stretch in the huntingtin protein has been identified as the pathogenetic cause of Huntington's disease (HD). Although the length of…”
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Motor learning by imagery is differentially affected in Parkinson’s and Huntington’s diseases by Yágüez, Lidia, Canavan, Anthony G.M, Lange, Herwig W, Hömberg, Völker

“…Studies of motor imagery and motor learning have thus far been concerned only with its effects on healthy subjects. Therefore, in order to investigate the…”
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Neurophysiological abnormalities in the westphal variant of Huntington's disease by Töpper, Rudolf, Schwarz, Michael, Lange, Herwig W., Hefter, Harald, Noth, Johannes

“…The Westphal variant of Huntington's disease (HD) is a distinct clinical entity of HD characterized by a rigid‐hypokinetic syndrome and is often associated…”
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Language functions in Huntington's disease by Podoll, K, Caspary, P, Lange, H W, Noth, J

“…A comprehensive language test battery (Aachen Aphasia Test) was administered to 45 patients in the early, middle or later stages of Huntington's disease (HD)…”
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Frequency dependent effects of rTMS on motor and cognitive functions in Huntington’s disease by Groiss, Stefan J., Netz, Johannes, Lange, Herwig W., Buetefisch, Cathrin M.

“…► Repetitive transcranial magnetic stimulation (rTMS) effectively modulates behavior. ► We tested rTMS of motor cortex in patients with Huntington disease…”
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Cortical and subcortical glucose consumption measured by PET in patients with Huntington's disease by Kuwert, T, Lange, H W, Langen, K J, Herzog, H, Aulich, A, Feinendegen, L E

“…In 23 patients with moderate to severe Huntington's disease (HD) and 21 normal volunteers, the regional cerebral metabolic rate of glucose consumption…”
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Impairment of rapid movement in Huntington's disease by Hefter, H, Hömberg, V, Lange, H W, Freund, H J

“…Patients with Huntington's disease (HD) and relatives at risk were examined with respect to their capacity to produce rapid voluntary motor activity. For this…”
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Huntington's Disease:N-Methyl-d-Aspartate Receptor Coagonist Glycine Is Increased in Platelets by Reilmann, Ralf, Rolf, Ludger H., Lange, Herwig W.

“…Experiments in vertebrates and striatal tissue cultures have provided evidence for a neuroexcitotoxic cause for the neurodegeneration in Huntington's disease…”
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Huntington's disease: the neuroexcitotoxin aspartate is increased in platelets and decreased in plasma by Reilmann, R, Rolf, L H, Lange, H W

“…The neural degeneration observed in the striata of patients with Huntington's disease (HD) can be reproduced by excitatory NMDA receptor agonists such as…”
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SPECT with HMPAO compared to PET with FDG in Huntington disease by Boecker, H, Kuwert, T, Langen, K J, Lange, H W, Czech, N, Ziemons, K, Herzog, H, Shikare, S, Weindl, A, Feinendegen, L E

“…It is the aim of this study to compare the performance of 99mTc-d,l-hexamethylpropyleneamine oxime (HMPAO) SPECT with that of [18F]fluorodeoxyglucose (FDG) PET…”
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Motor responses evoked by magnetic brain stimulation in Huntington's disease by Meyer, B U, Noth, J, Lange, H W, Bischoff, C, Machetanz, J, Weindl, A, Röricht, S, Benecke, R, Conrad, B

“…In 34 patients with manifest Huntington's disease (HD), and in 21 first-degree offspring without clinical signs or symptoms, the sizes, central motor latencies…”
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