Search Results - "Langdon, Wallace Y"

Regulation of C-Type Lectin Receptor-Mediated Antifungal Immunity by Tang, Juan, Lin, Guoxin, Langdon, Wallace Y, Tao, Lijian, Zhang, Jian

“…Of all the pathogen recognition receptor families, C-type lectin receptor (CLR)-induced intracellular signal cascades are indispensable for the initiation and…”
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Sequential ubiquitination of NLRP3 by RNF125 and Cbl-b limits inflammasome activation and endotoxemia by Tang, Juan, Tu, Sha, Lin, Guoxin, Guo, Hui, Yan, Chengkai, Liu, Qingjun, Huang, Ling, Tang, Na, Xiao, Yizhi, Pope, R Marshall, Rajaram, Murugesan V S, Amer, Amal O, Ahmer, Brian M, Gunn, John S, Wozniak, Daniel J, Tao, Lijian, Coppola, Vincenzo, Zhang, Liwen, Langdon, Wallace Y, Torrelles, Jordi B, Lipkowitz, Stanley, Zhang, Jian

“…Aberrant NLRP3 inflammasome activation contributes to the development of endotoxemia. The importance of negative regulation of NLRP3 inflammasomes remains…”
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Lymphoid Tissue and Plasmacytoid Dendritic Cells and Macrophages Do Not Share a Common Macrophage-Dendritic Cell-Restricted Progenitor by Sathe, Priyanka, Metcalf, Donald, Vremec, David, Naik, Shalin H., Langdon, Wallace Y., Huntington, Nicholas D., Wu, Li, Shortman, Ken

“…The relationship between dendritic cells (DCs) and macrophages is often debated. Here we ask whether steady-state, lymphoid-tissue-resident conventional DCs…”
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Negative regulation of receptor tyrosine kinases by ubiquitination: Key roles of the Cbl family of E3 ubiquitin ligases by Tang, Rong, Langdon, Wallace Y., Zhang, Jian

“…Receptor tyrosine kinases (RTKs) serve as transmembrane receptors that participate in a broad spectrum of cellular processes including cellular growth,…”
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Inhibition of CBLB protects from lethal Candida albicans sepsis by Wirnsberger, Gerald, Zwolanek, Florian, Asaoka, Tomoko, Kozieradzki, Ivona, Tortola, Luigi, Wimmer, Reiner A, Kavirayani, Anoop, Fresser, Friedrich, Baier, Gottfried, Langdon, Wallace Y, Ikeda, Fumiyo, Kuchler, Karl, Penninger, Josef M

“…Wirnsberger et al . report that an E3 ubiquitin ligase, CBLB, impairs immune control of Candida albicans and that targeting CBLB protects mice from lethal…”
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The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells by Paolino, Magdalena, Choidas, Axel, Wallner, Stephanie, Pranjic, Blanka, Uribesalgo, Iris, Loeser, Stefanie, Jamieson, Amanda M., Langdon, Wallace Y., Ikeda, Fumiyo, Fededa, Juan Pablo, Cronin, Shane J., Nitsch, Roberto, Schultz-Fademrecht, Carsten, Eickhoff, Jan, Menninger, Sascha, Unger, Anke, Torka, Robert, Gruber, Thomas, Hinterleitner, Reinhard, Baier, Gottfried, Wolf, Dominik, Ullrich, Axel, Klebl, Bert M., Penninger, Josef M.

“…The E3 ligase Cbl-b acts on TAM tyrosine kinase receptors and has a critical role in the regulation of natural killer (NK) cell rejection of metastatic…”
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Cytosolic LPS-induced caspase-11 oligomerization and activation is regulated by extended synaptotagmin 1 by Ma, Yilei, Zhao, Ru, Guo, Hui, Tong, Qingchao, Langdon, Wallace Y., Liu, Weiwei, Zhang, Jun, Zhang, Jian

“…Caspase-11 (Casp-11) is known to induce pyroptosis and defends against cytosol-invading bacterial pathogens, but its regulation remains poorly defined. Here,…”
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Targeting CBLB as a potential therapeutic approach for disseminated candidiasis by Xiao, Yun, Tang, Juan, Guo, Hui, Zhao, Yixia, Tang, Rong, Ouyang, Song, Zeng, Qiuming, Rappleye, Chad A, Rajaram, Murugesan V S, Schlesinger, Larry S, Tao, Lijian, Brown, Gordon D, Langdon, Wallace Y, Li, Belinda T, Zhang, Jian

“…Jian Zhang and colleagues identify the E3 ubiquitin ligase CBLB as a major inhibitor of host defense against Candida albicans infection and show that targeting…”
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CBL family E3 ubiquitin ligases control JAK2 ubiquitination and stability in hematopoietic stem cells and myeloid malignancies by Lv, Kaosheng, Jiang, Jing, Donaghy, Ryan, Riling, Christopher R, Cheng, Ying, Chandra, Vemika, Rozenova, Krasimira, An, Wei, Mohapatra, Bhopal C, Goetz, Benjamin T, Pillai, Vinodh, Han, Xu, Todd, Emily A, Jeschke, Grace R, Langdon, Wallace Y, Kumar, Suresh, Hexner, Elizabeth O, Band, Hamid, Tong, Wei

“…Janus kinase 2 (JAK2) is a central kinase in hematopoietic stem/progenitor cells (HSPCs), and its uncontrolled activation is a prominent oncogenic driver of…”
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c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses by Thien, Christine B F, Langdon, Wallace Y

“…The activation of signalling pathways by ligand engagement with transmembrane receptors is responsible for determining many aspects of cellular function and…”
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Ubiquitin Ligases CBL and CBL-B Maintain the Homeostasis and Immune Quiescence of Dendritic Cells by Tong, Haijun, Li, Xin, Zhang, Jinping, Gong, Liying, Sun, Weili, Calderon, Virginie, Zhang, Xiaochen, Li, Yue, Gadzinski, Adeline, Langdon, Wallace Y, Reizis, Boris, Zou, Yongrui, Gu, Hua

“…Dendritic cells (DCs) are composed of multiple lineages of hematopoietic cells and orchestrate immune responses upon detecting the danger and inflammatory…”
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E3 Ubiquitin Ligase Cbl-b Suppresses Proallergic T Cell Development and Allergic Airway Inflammation by Qiao, Guilin, Ying, Haiyan, Zhao, Yixia, Liang, Yanran, Guo, Hui, Shen, Huifeng, Li, Zhenping, Solway, Julian, Tao, Enxiang, Chiang, Y. Jeffrey, Lipkowitz, Stanley, Penninger, Josef M., Langdon, Wallace Y., Zhang, Jian

“…E3 ubiquitin ligase Cbl-b has emerged as a gatekeeper that controls the activation threshold of the T cell antigen receptor and maintains the balance between…”
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E3 Ubiquitin Ligase Cbl-b Regulates Pten via Nedd4 in T Cells Independently of Its Ubiquitin Ligase Activity by Guo, Hui, Qiao, Guilin, Ying, Haiyan, Li, Zhenping, Zhao, Yixia, Liang, Yanran, Yang, Lifen, Lipkowitz, Stanley, Penninger, Josef M., Langdon, Wallace Y., Zhang, Jian

“…E3 ubiquitin ligase Cbl-b plays a crucial role in T cell activation and tolerance induction. However, the molecular mechanism by which Cbl-b inhibits T cell…”
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Mechanisms of NKT Cell Anergy Induction Involve Cbl-b-Promoted Monoubiquitination of CARMA1 by Kojo, Satoshi, Elly, Chris, Harada, Yohsuke, Langdon, Wallace Y., Kronenberg, Mitchell, Liu, Yun-Cai

“…Repeated injection of α-galactosylceramide, an agonistic ligand for natural killer T (NKT) cells, results in long-term unresponsiveness or anergy, which…”
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Cbl-b restrains priming of pathogenic Th17 cells via the inhibition of IL-6 production by macrophages by Zeng, Qiuming, Tang, Na, Ma, Yilei, Guo, Hui, Zhao, Yixia, Tang, Rong, Yan, Chengkai, Ouyang, Song, Langdon, Wallace Y., Yang, Huan, O’Brien, Matthew C., Zhang, Jian

“…E3 ubiquitin ligase Cbl-b is involved in the maintenance of a balance between immunity and tolerance. Mice lacking Cbl-b are highly susceptible to experimental…”
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Dasatinib promotes the activation of quiescent hematopoietic stem cells in mice by Duyvestyn, Johanna M, Taylor, Samuel J, Dagger, Samantha A, Langdon, Wallace Y

“…Dasatinib is an orally available broad-spectrum tyrosine kinase inhibitor that is widely used to treat chronic myeloid leukemia. It is also in clinical trials…”
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The E3 ubiquitin ligase c-Cbl restricts development and functions of hematopoietic stem cells by Rathinam, Chozhavendan, Thien, Christine B F, Langdon, Wallace Y, Gu, Hua, Flavell, Richard A

“…Hematopoietic stem cells (HSCs) are multipotent progenitors that give rise to all types of blood cells. In the present study, we document that HSC development…”
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Flt3 inhibitor AC220 is a potent therapy in a mouse model of myeloproliferative disease driven by enhanced wild-type Flt3 signaling by Taylor, Samuel J., Dagger, Samantha A., Thien, Christine B.F., Wikstrom, Matthew E., Langdon, Wallace Y.

“…High levels of expression of wild-type Flt3 characterize many hematopoietic proliferative diseases and neoplasms, providing a potential therapeutic target…”
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Regulation of immune responses by E3 ubiquitin ligase Cbl-b by Tang, Rong, Langdon, Wallace Y., Zhang, Jian

“…•Cbl-b is a member of RING finger family E3 ubiquitin ligases.•By targeting different substrates in innate and adaptive immune cells, Cbl-b acts as a gate…”
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A TNF- and c-Cbl-dependent FLIPS-degradation pathway and its function in Mycobacterium tuberculosis–induced macrophage apoptosis by Kundu, Manikuntala, Pathak, Sushil Kumar, Kumawat, Kuldeep, Basu, Sanchita, Chatterjee, Gargi, Pathak, Shresh, Noguchi, Takuya, Takeda, Kohsuke, Ichijo, Hidenori, Thien, Christine B F, Langdon, Wallace Y, Basu, Joyoti

“…Apoptosis of Mycobacterium tuberculosis (Mtb)-infected macrophages restricts the spread of infection. Basu and colleagues delineate the signaling pathway…”
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