Search Results - "Langdon, Ryan J"

Influence of puberty timing on adiposity and cardiometabolic traits: A Mendelian randomisation study by Bell, Joshua A, Carslake, David, Wade, Kaitlin H, Richmond, Rebecca C, Langdon, Ryan J, Vincent, Emma E, Holmes, Michael V, Timpson, Nicholas J, Davey Smith, George

“…Earlier puberty is widely linked with future obesity and cardiometabolic disease. We examined whether age at puberty onset likely influences adiposity and…”
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Circulating Selenium and Prostate Cancer Risk: A Mendelian Randomization Analysis by Yarmolinsky, James, Bonilla, Carolina, Haycock, Philip C, Langdon, Ryan J Q, Lotta, Luca A, Langenberg, Claudia, Relton, Caroline L, Lewis, Sarah J, Evans, David M, Davey Smith, George, Martin, Richard M

“…In the Selenium and Vitamin E Cancer Prevention Trial (SELECT), selenium supplementation (causing a median 114 μg/L increase in circulating selenium) did not…”
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Causal Inference in Cancer Epidemiology: What Is the Role of Mendelian Randomization? by Yarmolinsky, James, Wade, Kaitlin H, Richmond, Rebecca C, Langdon, Ryan J, Bull, Caroline J, Tilling, Kate M, Relton, Caroline L, Lewis, Sarah J, Davey Smith, George, Martin, Richard M

“…Observational epidemiologic studies are prone to confounding, measurement error, and reverse causation, undermining robust causal inference. Mendelian…”
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Clinical judgement by primary care physicians for the diagnosis of all-cause dementia or cognitive impairment in symptomatic people by Creavin, Samuel T, Noel-Storr, Anna H, Langdon, Ryan J, Richard, Edo, Creavin, Alexandra L, Cullum, Sarah, Purdy, Sarah, Ben-Shlomo, Yoav

“…In primary care, general practitioners (GPs) unavoidably reach a clinical judgement about a patient as part of their encounter with patients, and so clinical…”
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Epigenetic modelling of former, current and never smokers by Langdon, Ryan J, Yousefi, Paul, Relton, Caroline L, Suderman, Matthew J

“…DNA methylation (DNAm) performs excellently in the discrimination of current and former smokers from never smokers, where AUCs > 0.9 are regularly reported…”
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A Phenome-Wide Mendelian Randomization Study of Pancreatic Cancer Using Summary Genetic Data by Langdon, Ryan J, Richmond, Rebecca C, Hemani, Gibran, Zheng, Jie, Wade, Kaitlin H, Carreras-Torres, Robert, Johansson, Mattias, Brennan, Paul, Wootton, Robyn E, Munafo, Marcus R, Smith, George Davey, Relton, Caroline L, Vincent, Emma E, Martin, Richard M, Haycock, Philip

“…The 5-year mortality rate for pancreatic cancer is among the highest of all cancers. Greater understanding of underlying causes could inform population-wide…”
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Clinical judgement by primary care physicians for the diagnosis of all-cause dementia or cognitive impairment in symptomatic people: a Cochrane Review by Creavin, Samuel T., Noel-Storr, Anna H, Langdon, Ryan J., Richard, Edo, Creavin, Alexandra L., Cullum, Sarah, Purdy, Sarah, Ben-Shlomo, Yoav

“…The target conditions were dementia and cognitive impairment (mild cognitive impairment and dementia) and we included studies with any appropriate reference…”
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Epigenetic prediction of complex traits and mortality in a cohort of individuals with oropharyngeal cancer by Langdon, Ryan J, Beynon, Rhona A, Ingarfield, Kate, Marioni, Riccardo E, McCartney, Daniel L, Martin, Richard M, Ness, Andy R, Pawlita, Michael, Waterboer, Tim, Relton, Caroline, Thomas, Steven J, Richmond, Rebecca C

“…DNA methylation (DNAm) variation is an established predictor for several traits. In the context of oropharyngeal cancer (OPC), where 5-year survival is ~ 65%,…”
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Genetic and Epigenetic Data as a Tool to Augment Understanding of Oropharyngeal Cancer by Langdon, Ryan J

“…Genetic and epigenetic data provide the opportunity to robustly appraise the causal effect of an exposure on an outcome of interest, improve understanding of…”
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