Search Results - "Langbehn, Douglas R."

Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington's disease in the TRACK-HD study: analysis of 36-month observational data by Tabrizi, Sarah J, Prof, Scahill, Rachael I, PhD, Owen, Gail, PhD, Durr, Alexandra, MD, Leavitt, Blair R, MDCM, Roos, Raymund A, Prof, Borowsky, Beth, PhD, Landwehrmeyer, Bernhard, Prof, Frost, Chris, Prof, Johnson, Hans, PhD, Craufurd, David, MD, Reilmann, Ralf, MD, Stout, Julie C, Prof, Langbehn, Douglas R, Prof

“…Summary Background TRACK-HD is a multinational prospective observational study of Huntington's disease (HD) that examines clinical and biological findings of…”
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Huntington disease: natural history, biomarkers and prospects for therapeutics by Ross, Christopher A., Aylward, Elizabeth H., Wild, Edward J., Langbehn, Douglas R., Long, Jeffrey D., Warner, John H., Scahill, Rachael I., Leavitt, Blair R., Stout, Julie C., Paulsen, Jane S., Reilmann, Ralf, Unschuld, Paul G., Wexler, Alice, Margolis, Russell L., Tabrizi, Sarah J.

“…Key Points No disease-modifying treatments are currently available for Huntington disease (HD), but clinical trials of potential compounds are imminent;…”
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Biological and clinical changes in premanifest and early stage Huntington's disease in the TRACK-HD study: the 12-month longitudinal analysis by Tabrizi, Sarah J, Prof, Scahill, Rachael I, PhD, Durr, Alexandra, MD, Roos, Raymund AC, MD, Leavitt, Blair R, FRCPC, Jones, Rebecca, MSc, Landwehrmeyer, G Bernhard, MD, Fox, Nick C, MD, Johnson, Hans, PhD, Hicks, Stephen L, PhD, Kennard, Christopher, FRCP, Craufurd, David, FRCPsych, Frost, Chris, PhD, Langbehn, Douglas R, MD, Reilmann, Ralf, MD, Stout, Julie C, PhD

“…Summary Background TRACK-HD is a prospective observational study of Huntington's disease (HD) that examines disease progression in premanifest individuals…”
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Potential endpoints for clinical trials in premanifest and early Huntington's disease in the TRACK-HD study: analysis of 24 month observational data by Tabrizi, Sarah J, Prof, Reilmann, Ralf, MD, Roos, Raymund AC, MD, Durr, Alexandra, MD, Leavitt, Blair, FRCP, Owen, Gail, PhD, Jones, Rebecca, MSc, Johnson, Hans, PhD, Craufurd, David, FRCPsych, Hicks, Stephen L, PhD, Kennard, Christopher, FRCP, Landwehrmeyer, Bernhard, MD, Stout, Julie C, PhD, Borowsky, Beth, PhD, Scahill, Rachael I, PhD, Frost, Chris, MA, Langbehn, Douglas R, PhD

“…Summary Background TRACK-HD is a prospective observational biomarker study in premanifest and early Huntington's disease (HD). In this report we define a…”
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Psychiatric Symptoms in Huntington’s Disease before Diagnosis: The Predict-HD Study by Duff, Kevin, Paulsen, Jane S, Beglinger, Leigh J, Langbehn, Douglas R, Stout, Julie C

“…Background Psychiatric disturbances are relatively common in manifest Huntington’s disease (HD), but less is known about these symptoms in the earliest phase…”
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Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data by Tabrizi, Sarah J, Langbehn, Douglas R, Leavitt, Blair R, Roos, Raymund AC, Durr, Alexandra, Craufurd, David, Kennard, Christopher, Hicks, Stephen L, Fox, Nick C, Scahill, Rachael I, Borowsky, Beth, Tobin, Allan J, Rosas, H Diana, Johnson, Hans, Reilmann, Ralf, Landwehrmeyer, Bernhard, Stout, Julie C

“…Summary Background Huntington's disease (HD) is an autosomal dominant, fully penetrant, neurodegenerative disease that most commonly affects adults in…”
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CAG-repeat length and the age of onset in Huntington disease (HD): A review and validation study of statistical approaches by Langbehn, Douglas R., Hayden, Michael R., Paulsen, Jane S.

“…CAG‐repeat length in the gene for HD is inversely correlated with age of onset (AOO). A number of statistical models elucidating the relationship between CAG…”
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Operationalizing compensation over time in neurodegenerative disease by Gregory, Sarah, Long, Jeffrey D, Klöppel, Stefan, Razi, Adeel, Scheller, Elisa, Minkova, Lora, Papoutsi, Marina, Mills, James A, Durr, Alexandra, Leavitt, Blair R, Roos, Raymund A C, Stout, Julie C, Scahill, Rachael I, Langbehn, Douglas R, Tabrizi, Sarah J, Rees, Geraint

“…In pre-clinical Huntington's disease, normal behaviour is maintained despite neurodegeneration, suggesting a mechanism of compensation. Gregory, Long et al …”
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A genetic association study of glutamine-encoding DNA sequence structures, somatic CAG expansion, and DNA repair gene variants, with Huntington disease clinical outcomes by Ciosi, Marc, Maxwell, Alastair, Cumming, Sarah A., Hensman Moss, Davina J., Alshammari, Asma M., Flower, Michael D., Durr, Alexandra, Leavitt, Blair R., Roos, Raymund A.C., Holmans, Peter, Jones, Lesley, Langbehn, Douglas R., Kwak, Seung, Tabrizi, Sarah J., Monckton, Darren G.

“…Huntington disease (HD) is caused by an unstable CAG/CAA repeat expansion encoding a toxic polyglutamine tract. Here, we tested the hypotheses that HD outcomes…”
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Longer CAG repeat length is associated with shorter survival after disease onset in Huntington disease by Langbehn, Douglas R.

“…It is well known that the length of the CAG trinucleotide expansion of the huntingtin gene is associated with many aspects of Huntington disease progression…”
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The impact of occipital lobe cortical thickness on cognitive task performance: An investigation in Huntington's Disease by Johnson, Eileanoir B., Rees, Elin M., Labuschagne, Izelle, Durr, Alexandra, Leavitt, Blair R., Roos, Raymund A.C., Reilmann, Ralf, Johnson, Hans, Hobbs, Nicola Z., Langbehn, Douglas R., Stout, Julie C., Tabrizi, Sarah J., Scahill, Rachael I.

“…The occipital lobe is an important visual processing region of the brain. Following consistent findings of early neural changes in the occipital lobe in…”
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Cerebral cortex structure in prodromal Huntington disease by Nopoulos, Peggy C, Aylward, Elizabeth H, Ross, Christopher A, Johnson, Hans J, Magnotta, Vincent A, Juhl, Andrew R, Pierson, Ronald K, Mills, James, Langbehn, Douglas R, Paulsen, Jane S

“…Abstract Neuroimaging studies of subjects who are gene-expanded for Huntington Disease, but not yet diagnosed (termed prodromal HD), report that the cortex is…”
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Early atrophy of pallidum and accumbens nucleus in Huntington’s disease by van den Bogaard, Simon J. A., Dumas, Eve M., Acharya, Tanka P., Johnson, Hans, Langbehn, Douglas R., Scahill, Rachael I., Tabrizi, Sarah J., van Buchem, Mark A., van der Grond, Jeroen, Roos, Raymund A. C.

“…In Huntington’s disease (HD) atrophy of the caudate nucleus and putamen has been described many years before clinical manifestation. Volume changes of the…”
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Response to Lee et al by Langbehn, Douglas R

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Progressive alterations in white matter microstructure across the timecourse of Huntington's disease by Estevez‐Fraga, Carlos, Elmalem, Michael S., Papoutsi, Marina, Durr, Alexandra, Rees, Elin M., Hobbs, Nicola Z., Roos, Raymund A. C., Landwehrmeyer, Bernhard, Leavitt, Blair R., Langbehn, Douglas R., Scahill, Rachael I., Rees, Geraint, Tabrizi, Sarah J., Gregory, Sarah

“…Background Whole‐brain longitudinal diffusion studies are crucial to examine changes in structural connectivity in neurodegeneration. Here, we investigated the…”
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Behavioral features in child and adolescent huntingtin gene‐mutation carriers by Reasoner, Erin E., Plas, Ellen, Al‐Kaylani, Hend M., Langbehn, Douglas R., Conrad, Amy L., Schultz, Jordan L., Epping, Eric A., Magnotta, Vincent A., Nopoulos, Peggy C.

“…Introduction We compared neuropsychiatric symptoms between child and adolescent huntingtin gene‐mutation carriers and noncarriers. Given previous evidence of…”
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Self-Paced Timing Detects and Tracks Change in Prodromal Huntington Disease by Rowe, Kelly C, Paulsen, Jane S, Langbehn, Douglas R, Duff, Kevin, Beglinger, Leigh J, Wang, Chiachi, O'Rourke, Justin J. F, Stout, Julie C, Moser, David J

“…Objective: This study compares self-paced timing performance (cross-sectionally and longitudinally) between participants with prodromal Huntington's disease (…”
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Clinical Outcomes and Selection Criteria for Prodromal Huntington's Disease Trials by Langbehn, Douglas R., Hersch, Steven

“…Background Huntington's disease (HD) develops in individuals with extended cytosine‐adenine‐guanine (CAG) repeats within the huntingtin (HTT) gene, causing…”
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Utility of the Huntington's Disease Prognostic Index Score for a Perimanifest Clinical Trial by Langbehn, Douglas R., Fine, Elisabeth M., Meier, Andreas, Hersch, Steven

“…Background Subtle neurodegenerative motor and cognitive impairments accumulate over a prodromal period several years before clinical diagnosis of Huntington's…”
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Abnormal brain development in child and adolescent carriers of mutant huntingtin by van der Plas, Ellen, Langbehn, Douglas R, Conrad, Amy L, Koscik, Timothy R, Tereshchenko, Alexander, Epping, Eric A, Magnotta, Vincent A, Nopoulos, Peggy C

“…OBJECTIVEThe huntingtin gene is critical for the formation and differentiation of the CNS, which raises questions about the neurodevelopmental effect of CAG…”
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