Search Results - "Lang, Yinzhi"

In Vivo Anti-Cancer Mechanism of Low-Molecular-Weight Fucosylated Chondroitin Sulfate (LFCS) from Sea Cucumber Cucumaria frondosa by Liu, Xiaoxiao, Liu, Yong, Hao, Jiejie, Zhao, Xiaoliang, Lang, Yinzhi, Fan, Fei, Cai, Chao, Li, Guoyun, Zhang, Lijuan, Yu, Guangli

“…The low-molecular-weight fucosylated chondroitin sulfate (LFCS) was prepared from native fucosylated chondroitin sulfate (FCS), which was extracted and…”
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Applications of mass spectrometry to structural analysis of marine oligosaccharides by Lang, Yinzhi, Zhao, Xia, Liu, Lili, Yu, Guangli

“…Marine oligosaccharides have attracted increasing attention recently in developing potential drugs and biomaterials for their particular physical and chemical…”
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Next generation antibiotic combinations to combat pan-drug resistant Klebsiella pneumoniae by Kaur, Jan Naseer, Singh, Navaldeep, Smith, Nicholas M., Klem, Jack F., Cha, Raymond, Lang, Yinzhi, Chen, Liang, Kreiswirth, Barry, Holden, Patricia N., Bulitta, Jürgen B., Tsuji, Brian T.

“…Antimicrobial resistance has emerged as one of the leading public health threats of the twenty-first century. Gram-negative pathogens have been a major…”
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Why Molnupiravir Fails in Hospitalized Patients by Brown, Ashley N, Lang, Yinzhi, Zhou, Jieqiang, Franco, Evelyn J, Hanrahan, Kaley C, Bulitta, Juergen B, Drusano, George L

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has radically altered daily life…”
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Analysis of structural heterogeneity of fucoidan from Hizikia fusiforme by ES-CID-MS/MS by Wang, Peipei, Zhao, Xiaoliang, Lv, Youjing, Liu, Yanan, Lang, Yinzhi, Wu, Jiandong, Liu, Xin, Li, Miaomiao, Yu, Guangli

“…► A heterogeneous fucoidan was isolated and purified from brown alga Hizikia fusiforme. ► The sequence of oligosaccharides prepared by partial acid hydrolysis…”
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Comparison of Different Labeling Techniques for the LC-MS Profiling of Human Milk Oligosaccharides by Lang, Yinzhi, Zhang, Yongzhen, Wang, Chen, Huang, Limei, Liu, Xiaoxiao, Song, Ni, Li, Guoyun, Yu, Guangli

“…Human milk oligosaccharides (HMOs) exhibit various biological activities for infants, such as serving as prebiotics, blocking pathogens, and aiding in brain…”
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Extraction, Isolation, Structural Characterization and Anti-Tumor Properties of an Apigalacturonan-Rich Polysaccharide from the Sea Grass Zostera caespitosa Miki by Lv, Youjing, Shan, Xindi, Zhao, Xia, Cai, Chao, Zhao, Xiaoliang, Lang, Yinzhi, Zhu, He, Yu, Guangli

“…An apigalacturonan (AGA)-rich polysaccharide, ZCMP, was isolated from the sea grass Zostera caespitosa Miki. The depolymerized fragments derived from ZCMP were…”
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Effect of Different Piperacillin-Tazobactam Dosage Regimens on Synergy of the Combination with Tobramycin against Pseudomonas aeruginosa for the Pharmacokinetics of Critically Ill Patients in a Dynamic Infection Model by Tait, Jessica R, Bilal, Hajira, Rogers, Kate E, Lang, Yinzhi, Kim, Tae-Hwan, Zhou, Jieqiang, Wallis, Steven C, Bulitta, Jürgen B, Kirkpatrick, Carl M J, Paterson, David L, Lipman, Jeffrey, Bergen, Phillip J, Roberts, Jason A, Nation, Roger L, Landersdorfer, Cornelia B

“…We evaluated piperacillin-tazobactam and tobramycin regimens against isolates from critically ill patients. Static-concentration time-kill studies (SCTK)…”
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Population pharmacokinetics of enrofloxacin and florfenicol in the giant danio (Devario aequipinnatus) following oral administration of both antibiotics and bath administration of enrofloxacin by Vorbach, Bryan S., Zhou, Jieqiang, Lang, Yinzhi, Bulitta, Jürgen B., Yanong, Roy P.E.

“…The lack of pharmacokinetic and drug exposure data, even for commonly utilized antibiotics, in freshwater ornamental teleost fish species magnifies the…”
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Glycosaminoglycanomic profiling of human milk in different stages of lactation by liquid chromatography-tandem mass spectrometry by Wang, Chen, Lang, Yinzhi, Li, Qinying, Jin, Xin, Li, Guoyun, Yu, Guangli

“…•Using LC-MS to rapidly determine trace concentrations (pg/μL) of GAGs in human milk.•Compare composition difference of complex GAGs in human milk in different…”
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Low anticoagulant heparin oligosaccharides as inhibitors of BACE-1, the Alzheimer’s β-secretase by Zhang, Xiao, Zhao, Xiaoliang, Lang, Yinzhi, Li, Qinying, Liu, Xiaoxiao, Cai, Chao, Hao, Jiejie, Li, Guoyun, Yu, Guangli

“…•A novel and natural low anticoagulant heparin (LAH) was isolated and purified.•Low molecular weight derivatives of LAH were prepared and…”
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Improved characterization of aminoglycoside penetration into human lung epithelial lining fluid via population pharmacokinetics by Shin, Eunjeong, Zhang, Yongzhen, Zhou, Jieqiang, Lang, Yinzhi, Sayed, Alaa R M, Werkman, Carolin, Jiao, Yuanyuan, Kumaraswamy, Monika, Bulman, Zackery P, Luna, Brian M, Bulitta, Jürgen B

“…Aminoglycosides are important treatment options for serious lung infections, but modeling analyses to quantify their human lung epithelial lining fluid (ELF)…”
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Mechanistic Insights to Combating NDM- and CTX-M-Coproducing Klebsiella pneumoniae by Targeting Cell Wall Synthesis and Outer Membrane Integrity by Smith, Nicholas M, Boissonneault, Katie Rose, Chen, Liang, Petraitis, Vidmantas, Petraitiene, Ruta, Tao, Xun, Zhou, Jieqiang, Lang, Yinzhi, Kavaliauskas, Povilas, Bulman, Zackery P, Holden, Patricia N, Cha, Raymond, Bulitta, Jürgen B, Kreiswirth, Barry N, Walsh, Thomas J, Tsuji, Brian T

“…Metallo-β-lactamase (MBL)-producing Gram-negative bacteria cause infections associated with high rates of morbidity and mortality. Currently, a leading regimen…”
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Generating Genotype-Specific Aminoglycoside Combinations with Ceftazidime/Avibactam for KPC-Producing Klebsiella pneumoniae by Huang, Yanqin, Sokolowski, Karol, Rana, Amisha, Singh, Nidhi, Wang, Jiping, Chen, Ke, Lang, Yinzhi, Zhou, Jieqiang, Kadiyala, Neera, Krapp, Fiorella, Ozer, Egon A, Hauser, Alan R, Li, Jian, Bulitta, Jürgen B, Bulman, Zackery P

“…Antibiotic combinations, including ceftazidime/avibactam (CAZ/AVI), are frequently employed to combat KPC-producing Klebsiella pneumoniae (KPC-Kp), though such…”
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Comprehensive stability analysis of 13 β-lactams and β-lactamase inhibitors in in vitro media, and novel supplement dosing strategy to mitigate thermal drug degradation by Zhou, Jieqiang, Qian, Yuli, Lang, Yinzhi, Zhang, Yongzhen, Tao, Xun, Moya, Bartolome, Sayed, Alaa R M, Landersdorfer, Cornelia B, Shin, Eunjeong, Werkman, Carolin, Smith, Nicholas M, Kim, Tae Hwan, Kumaraswamy, Monika, Shin, Beom Soo, Tsuji, Brian T, Bonomo, Robert A, Lee, Richard E, Bulitta, Jürgen B

“…Non-clinical antibiotic development relies on susceptibility and infection model studies. Validating the achievement of the targeted drug concentrations is…”
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Simulated Intravenous versus Inhaled Tobramycin with or without Intravenous Ceftazidime Evaluated against Hypermutable Pseudomonas aeruginosa via a Dynamic Biofilm Model and Mechanism-Based Modeling by Bilal, Hajira, Tait, Jessica R, Lang, Yinzhi, Zhou, Jieqiang, Bergen, Phillip J, Peleg, Anton Y, Bulitta, Jürgen B, Oliver, Antonio, Nation, Roger L, Landersdorfer, Cornelia B

“…Acute exacerbations of chronic respiratory infections in patients with cystic fibrosis are highly challenging due to hypermutable Pseudomonas aeruginosa,…”
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First Penicillin-Binding Protein Occupancy Patterns for 15 β-Lactams and β-Lactamase Inhibitors in Mycobacterium abscessus by Sayed, Alaa R M, Shah, Nirav R, Basso, Kari B, Kamat, Manasi, Jiao, Yuanyuan, Moya, Bartolome, Sutaria, Dhruvitkumar S, Lang, Yinzhi, Tao, Xun, Liu, Weiguo, Shin, Eunjeong, Zhou, Jieqiang, Werkman, Carolin, Louie, Arnold, Drusano, George L, Bulitta, Jürgen B

“…causes serious infections that often require over 18 months of antibiotic combination therapy. There is no standard regimen for the treatment of infections,…”
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Ceftolozane-Tazobactam against Pseudomonas aeruginosa Cystic Fibrosis Clinical Isolates in the Hollow-Fiber Infection Model: Challenges Imposed by Hypermutability and Heteroresistance by Tait, Jessica R, Harper, Marina, Cortés-Lara, Sara, Rogers, Kate E, López-Causapé, Carla, Smallman, Thomas R, Lang, Yinzhi, Lee, Wee Leng, Zhou, Jieqiang, Bulitta, Jürgen B, Nation, Roger L, Boyce, John D, Oliver, Antonio, Landersdorfer, Cornelia B

“…Pseudomonas aeruginosa remains a challenge in chronic respiratory infections in cystic fibrosis (CF). Ceftolozane-tazobactam has not yet been evaluated against…”
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Synergistic effects of inhaled aztreonam plus tobramycin on hypermutable cystic fibrosis Pseudomonas aeruginosa isolates in a dynamic biofilm model evaluated by mechanism-based modelling and whole genome sequencing by Breen, Siobhonne K.J., Harper, Marina, López-Causapé, Carla, Rogers, Kate E., Tait, Jessica R., Smallman, Thomas R., Lang, Yinzhi, Lee, Wee L., Zhou, Jieqiang, Zhang, Yongzhen, Bulitta, Jurgen B., Nation, Roger L., Oliver, Antonio, Boyce, John D., Landersdorfer, Cornelia B.

“…•Hypermutable biofilm-forming P. aeruginosa in the lungs of patients with cystic fibrosis is a major treatment challenge.•Simulated lung fluid exposure of…”
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Ceftolozane/tazobactam plus tobramycin against free-floating and biofilm bacteria of hypermutable Pseudomonas aeruginosa epidemic strains: Resistance mechanisms and synergistic activity by Agyeman, Akosua A., López-Causapé, Carla, Rogers, Kate E., Lucas, Deanna Deveson, Cortés-Lara, Sara, Gomis-Font, Maria A., Fraile-Ribot, Pablo, Figuerola, Joan, Lang, Yinzhi, Franklyn, Eva R.T., Lee, Wee Leng, Zhou, Jieqiang, Zhang, Yongzhen, Bulitta, Jurgen B., Boyce, John D., Nation, Roger L., Oliver, Antonio, Landersdorfer, Cornelia B.

“…•Hypermutable biofilm-forming Pseudomonas aeruginosa in lungs of cystic fibrosis patients is a major treatment challenge.•Simulated exposures to…”
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