Search Results - "Lang, Pauline A."

High-throughput screen with the l,d-transpeptidase LdtMt2 of Mycobacterium tuberculosis reveals novel classes of covalently reacting inhibitors by de Munnik, Mariska, Lang, Pauline A, De Dios Anton, Francisco, Cacho, Mónica, Bates, Robert H, Brem, Jürgen, Beatriz Rodríguez Miquel, Schofield, Christopher J

“…Disruption of bacterial cell wall biosynthesis in Mycobacterium tuberculosis is a promising target for treating tuberculosis. The l,d-transpeptidase LdtMt2,…”
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Biochemical and crystallographic studies of l,d-transpeptidase 2 from Mycobacterium tuberculosis with its natural monomer substrate by de Munnik, Mariska, Lang, Pauline A., Calvopiña, Karina, Rabe, Patrick, Brem, Jürgen, Schofield, Christopher J.

“…The essential l,d -transpeptidase of Mycobacterium tuberculosis (Ldt Mt2 ) catalyses the formation of 3 → 3 cross-links in cell wall peptidoglycan and is a…”
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Bicyclic Boronates as Potent Inhibitors of AmpC, the Class C β-Lactamase from Escherichia coli by Lang, Pauline A, Parkova, Anete, Leissing, Thomas M, Calvopiña, Karina, Cain, Ricky, Krajnc, Alen, Panduwawala, Tharindi D, Philippe, Jules, Fishwick, Colin W G, Trapencieris, Peteris, Page, Malcolm G P, Schofield, Christopher J, Brem, Jürgen

“…Resistance to β-lactam antibacterials, importantly via production of β-lactamases, threatens their widespread use. Bicyclic boronates show promise as…”
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Anaerobic fixed-target serial crystallography by Rabe, Patrick, Beale, John H, Butryn, Agata, Aller, Pierre, Dirr, Anna, Lang, Pauline A, Axford, Danny N, Carr, Stephen B, Leissing, Thomas M, McDonough, Michael A, Davy, Bradley, Ebrahim, Ali, Orlans, Julien, Storm, Selina L.S, Orville, Allen M, Schofield, Christopher J, Owen, Robin L

“…Cryogenic X-ray diffraction is a powerful tool for crystallographic studies on enzymes including oxygenases and oxidases. Amongst the benefits that…”
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Will morphing boron-based inhibitors beat the β-lactamases? by Krajnc, Alen, Lang, Pauline A, Panduwawala, Tharindi D, Brem, Jürgen, Schofield, Christopher J

“…The β-lactams remain the most important antibacterials, but their use is increasingly compromised by resistance, importantly by β-lactamases. Although β-lactam…”
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Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases by Krajnc, Alen, Brem, Jürgen, Hinchliffe, Philip, Calvopiña, Karina, Panduwawala, Tharindi D, Lang, Pauline A, Kamps, Jos J. A. G, Tyrrell, Jonathan M, Widlake, Emma, Saward, Benjamin G, Walsh, Timothy R, Spencer, James, Schofield, Christopher J

“…The bicyclic boronate VNRX-5133 (taniborbactam) is a new type of β-lactamase inhibitor in clinical development. We report that VNRX-5133 inhibits…”
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Molecular Basis of Class A β-Lactamase Inhibition by Relebactam by Tooke, Catherine L, Hinchliffe, Philip, Lang, Pauline A, Mulholland, Adrian J, Brem, Jürgen, Schofield, Christopher J, Spencer, James

“…β-Lactamase production is the major β-lactam resistance mechanism in Gram-negative bacteria. β-Lactamase inhibitors (BLIs) efficacious against serine…”
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Studies on enmetazobactam clarify mechanisms of widely used β-lactamase inhibitors by Lang, Pauline A, Raj, Ritu, Tumber, Anthony, Lohans, Christopher T, Rabe, Patrick, Robinson, Carol V, Brem, Jürgen, Schofield, Christopher J

“…β-Lactams are the most important class of antibacterials, but their use is increasingly compromised by resistance, most importantly via serine β-lactamase…”
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Structural Investigations of the Inhibition of Escherichia coli AmpC β-Lactamase by Diazabicyclooctanes by Lang, Pauline A, Leissing, Thomas M, Page, Malcolm G P, Schofield, Christopher J, Brem, Jürgen

“…β-Lactam antibiotics are presently the most important treatments for infections by pathogenic , but their use is increasingly compromised by β-lactamases,…”
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High-throughput screen with the l,d-transpeptidase Ldt Mt2 of Mycobacterium tuberculosis reveals novel classes of covalently reacting inhibitors by de Munnik, Mariska, Lang, Pauline A, De Dios Anton, Francisco, Cacho, Mónica, Bates, Robert H, Brem, Jürgen, Rodríguez Miquel, Beatriz, Schofield, Christopher J

“…Disruption of bacterial cell wall biosynthesis in is a promising target for treating tuberculosis. The l,d-transpeptidase Ldt , which is responsible for the…”
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How Clavulanic Acid Inhibits Serine β‐Lactamases by Lang, Pauline A., Munnik, Mariska, Oluwole, Abraham O., Claridge, Timothy D. W., Robinson, Carol V., Brem, Jürgen, Schofield, Christopher J.

“…Clavulanic acid is a medicinally important inhibitor of serine β‐lactamases (SBLs). We report studies on the mechanisms by which clavulanic acid inhibits…”
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Pretargeted PET Imaging with a TCO-Conjugated Anti-CD44v6 Chimeric mAb U36 and [ 89 Zr]Zr-DFO-PEG 5 -Tz by Lumen, Dave, Vugts, Danielle, Chomet, Marion, Imlimthan, Surachet, Sarparanta, Mirkka, Vos, Ricardo, Schreurs, Maxime, Verlaan, Mariska, Lang, Pauline A, Hippeläinen, Eero, Beaino, Wissam, Windhorst, Albert D, Airaksinen, Anu J

“…The recent advances in the production of engineered antibodies have facilitated the development and application of tailored, target-specific antibodies…”
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An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography by Butryn, Agata, Simon, Philipp S., Aller, Pierre, Hinchliffe, Philip, Massad, Ramzi N., Leen, Gabriel, Tooke, Catherine L., Bogacz, Isabel, Kim, In-Sik, Bhowmick, Asmit, Brewster, Aaron S., Devenish, Nicholas E., Brem, Jürgen, Kamps, Jos J. A. G., Lang, Pauline A., Rabe, Patrick, Axford, Danny, Beale, John H., Davy, Bradley, Ebrahim, Ali, Orlans, Julien, Storm, Selina L. S., Zhou, Tiankun, Owada, Shigeki, Tanaka, Rie, Tono, Kensuke, Evans, Gwyndaf, Owen, Robin L., Houle, Frances A., Sauter, Nicholas K., Schofield, Christopher J., Spencer, James, Yachandra, Vittal K., Yano, Junko, Kern, Jan F., Orville, Allen M.

“…Serial femtosecond crystallography has opened up many new opportunities in structural biology. In recent years, several approaches employing light-inducible…”
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Pretargeted PET Imaging with a TCO-Conjugated Anti-CD44v6 Chimeric mAb U36 and [89Zr]Zr-DFO-PEG5‑Tz by Lumen, Dave, Vugts, Danielle, Chomet, Marion, Imlimthan, Surachet, Sarparanta, Mirkka, Vos, Ricardo, Schreurs, Maxime, Verlaan, Mariska, Lang, Pauline A., Hippeläinen, Eero, Beaino, Wissam, Windhorst, Albert D., Airaksinen, Anu J.

“…The recent advances in the production of engineered antibodies have facilitated the development and application of tailored, target-specific antibodies…”
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Mapping the Hydrophobic Substrate Binding Site of Phenylalanine Ammonia-Lyase from Petroselinum crispum by Nagy, Emma Z. A, Tork, Souad D, Lang, Pauline A, Filip, Alina, Irimie, Florin D, Poppe, László, Toşa, Monica I, Schofield, Christopher J, Brem, Jürgen, Paizs, Csaba, Bencze, László C

“…Modification of the hydrophobic binding pocket of phenylalanine ammonia-lyase from Petroselinum crispum (PcPAL) enables increased activity and selectivity…”
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Targeting the Mycobacterium tuberculosis transpeptidase Ldt Mt2 with cysteine-reactive inhibitors including ebselen by de Munnik, Mariska, Lohans, Christopher T, Lang, Pauline A, Langley, Gareth W, Malla, Tika R, Tumber, Anthony, Schofield, Christopher J, Brem, Jürgen

“…The l,d-transpeptidases (Ldts) are promising antibiotic targets for treating tuberculosis. We report screening of cysteine-reactive inhibitors against LdtMt2…”
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X-ray free-electron laser studies reveal correlated motion during isopenicillin N synthase catalysis by Rabe, Patrick, Kamps, Jos J A G, Sutherlin, Kyle D, Linyard, James D S, Aller, Pierre, Pham, Cindy C, Makita, Hiroki, Clifton, Ian, McDonough, Michael A, Leissing, Thomas M, Shutin, Denis, Lang, Pauline A, Butryn, Agata, Brem, Jürgen, Gul, Sheraz, Fuller, Franklin D, Kim, In-Sik, Cheah, Mun Hon, Fransson, Thomas, Bhowmick, Asmit, Young, Iris D, O'Riordan, Lee, Brewster, Aaron S, Pettinati, Ilaria, Doyle, Margaret, Joti, Yasumasa, Owada, Shigeki, Tono, Kensuke, Batyuk, Alexander, Hunter, Mark S, Alonso-Mori, Roberto, Bergmann, Uwe, Owen, Robin L, Sauter, Nicholas K, Claridge, Timothy D W, Robinson, Carol V, Yachandra, Vittal K, Yano, Junko, Kern, Jan F, Orville, Allen M, Schofield, Christopher J

“…Isopenicillin synthase (IPNS) catalyzes the unique reaction of l-δ-(α-aminoadipoyl)-l-cysteinyl-d-valine (ACV) with dioxygen giving isopenicillin (IPN), the…”
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Cover Feature: How Clavulanic Acid Inhibits Serine β‐Lactamases (ChemBioChem 22/2024) by Lang, Pauline A., Munnik, Mariska, Oluwole, Abraham O., Claridge, Timothy D. W., Robinson, Carol V., Brem, Jürgen, Schofield, Christopher J.

“…Clavulanic acid is a densely functionalized low mass (C8H9NO5) drug, which is used to protect penicillins and other β‐lactam antibiotics from hydrolysis by…”
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High-throughput screen with the -transpeptidase Ldt of reveals novel classes of covalently reacting inhibitors by de Munnik, Mariska, Lang, Pauline A, De Dios Anton, Francisco, Cacho, Mónica, Bates, Robert H, Brem, Jürgen, Rodríguez Miquel, Beatriz, Schofield, Christopher J

“…Disruption of bacterial cell wall biosynthesis in Mycobacterium tuberculosis is a promising target for treating tuberculosis. The l,d -transpeptidase Ldt Mt2 ,…”
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Bicyclic Boronates as Potent Inhibitors of AmpC, the Class C [beta]-Lactamase from Escherichia coli by Lang, Pauline A, Parkova, Anete, Leissing, Thomas M, Calvopina, Karina, Cain, Ricky, Krajnc, Alen, Panduwawala, Tharindi D, Philippe, Jules, Fishwick, Colin W.G, Trapencieris, Peteris, Page, Malcolm G.P, Schofield, Christopher J, Brem, Jurgen

“…Resistance to [beta]-lactam antibacterials, importantly via production of [beta]-lactamases, threatens their widespread use. Bicyclic boronates show promise as…”
Get full text