Search Results - "Lang, Charles"

The PAR proteins: from molecular circuits to dynamic self-stabilizing cell polarity by Lang, Charles F, Munro, Edwin

“…PAR proteins constitute a highly conserved network of scaffolding proteins, adaptors and enzymes that form and stabilize cortical asymmetries in response to…”
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Importance of the Innate Immune Response in Skeletal Muscle to Sepsis-Induced Alterations in Protein Balance by Lang, Charles H.

“…There is growing appreciation that skeletal muscle is a fully functional component of the body's innate immune system with the potential to actively…”
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Dysregulation of skeletal muscle protein metabolism by alcohol by Steiner, Jennifer L, Lang, Charles H

“…Alcohol abuse, either by acute intoxication or prolonged excessive consumption, leads to pathological changes in many organs and tissues including skeletal…”
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Etiology of alcoholic cardiomyopathy: Mitochondria, oxidative stress and apoptosis by Steiner, Jennifer L., Lang, Charles H.

“…Putative mechanisms leading to the development of alcoholic cardiomyopathy (ACM) include the interrelated cellular processes of mitochondria metabolism,…”
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Mechanisms Underlying Muscle Protein Imbalance Induced by Alcohol by Kimball, Scot R, Lang, Charles H

“…Both acute intoxication and longer-term cumulative ingestion of alcohol negatively impact the metabolic phenotype of both skeletal and cardiac muscle,…”
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Oligomerization of peripheral membrane proteins provides tunable control of cell surface polarity by Lang, Charles F., Munro, Edwin M.

“…Asymmetric distributions of peripheral membrane proteins define cell polarity across all kingdoms of life. Non-linear positive feedback on membrane binding is…”
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Alcohol, Adipose Tissue and Lipid Dysregulation by Steiner, Jennifer L, Lang, Charles H

“…Chronic alcohol consumption perturbs lipid metabolism as it increases adipose tissue lipolysis and leads to ectopic fat deposition within the liver and the…”
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Mechanisms and Disease Associations of Haplotype-Dependent Allele-Specific DNA Methylation by Do, Catherine, Lang, Charles F., Lin, John, Darbary, Huferesh, Krupska, Izabela, Gaba, Aulona, Petukhova, Lynn, Vonsattel, Jean-Paul, Gallagher, Mary P., Goland, Robin S., Clynes, Raphael A., Dwork, Andrew, Kral, John G., Monk, Catherine, Christiano, Angela M., Tycko, Benjamin

“…Haplotype-dependent allele-specific methylation (hap-ASM) can impact disease susceptibility, but maps of this phenomenon using stringent criteria in…”
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Resistin production does not affect outcomes in a mouse model of acute surgical sepsis by Bonavia, Anthony S, Chroneos, Zissis C, Ruiz-Velasco, Victor, Lang, Charles H

“…Because of the strong correlation between the blood concentration of circulating resistin and the illness severity of septic patients, resistin has been…”
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Control of skeletal muscle atrophy in response to disuse: clinical/preclinical contentions and fallacies of evidence by Atherton, Philip J, Greenhaff, Paul L, Phillips, Stuart M, Bodine, Sue C, Adams, Christopher M, Lang, Charles H

“…Muscle wasting resulting wholly or in part from disuse represents a serious medical complication that, when prolonged, can increase morbidity and mortality…”
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Alcohol impairs skeletal muscle protein synthesis and mTOR signaling in a time-dependent manner following electrically stimulated muscle contraction by Steiner, Jennifer L, Lang, Charles H

“…Alcohol (EtOH) decreases protein synthesis and mammalian target of rapamycin (mTOR)-mediated signaling and blunts the anabolic response to growth factors in…”
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Impact of Alcohol on Glycemic Control and Insulin Action by Steiner, Jennifer L, Crowell, Kristen T, Lang, Charles H

“…Alcohol has profound effects on tissue and whole-body fuel metabolism which contribute to the increased morbidity and mortality in individuals with alcohol use…”
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Delayed recovery of skeletal muscle mass following hindlimb immobilization in mTOR heterozygous mice by Lang, Susan M, Kazi, Abid A, Hong-Brown, Ly, Lang, Charles H

“…The present study addressed the hypothesis that reducing mTOR, as seen in mTOR heterozygous (+/-) mice, would exaggerate the changes in protein synthesis and…”
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Contractility and Myofibrillar Content in Skeletal Muscle are Decreased During Post-Sepsis Recovery, But Not During the Acute Phase of Sepsis by Crowell, Kristen T., Lang, Charles H.

“…ABSTRACTConvalescence in humans after severe sepsis occurs over weeks to months and is associated with prolonged functional disabilities and impaired…”
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Simulated space radiation sensitizes bone but not muscle to the catabolic effects of mechanical unloading by Krause, Andrew R, Speacht, Toni L, Zhang, Yue, Lang, Charles H, Donahue, Henry J

“…Deep space travel exposes astronauts to extended periods of space radiation and mechanical unloading, both of which may induce significant muscle and bone…”
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Ethanol acutely antagonizes the refeeding-induced increase in mTOR-dependent protein synthesis and decrease in autophagy in skeletal muscle by Steiner, Jennifer L., Lang, Charles H.

“…The purpose of this study was to determine the impact of acute ethanol administration on the major signal transduction pathways in skeletal muscle responsible…”
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Alcoholic Cardiomyopathy: Disrupted Protein Balance and Impaired Cardiomyocyte Contractility by Steiner, Jennifer L., Lang, Charles H.

“…Alcoholic cardiomyopathy (ACM) can develop after consumption of relatively large amounts of alcohol over time or from acute binge drinking. Of the many factors…”
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Leucine and Protein Metabolism in Obese Zucker Rats by She, Pengxiang, Olson, Kristine C, Kadota, Yoshihiro, Inukai, Ayami, Shimomura, Yoshiharu, Hoppel, Charles L, Adams, Sean H, Kawamata, Yasuko, Matsumoto, Hideki, Sakai, Ryosei, Lang, Charles H, Lynch, Christopher J, Blachier, François

“…Branched-chain amino acids (BCAAs) are circulating nutrient signals for protein accretion, however, they increase in obesity and elevations appear to be…”
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Interdependence of Muscle Atrophy and Bone Loss Induced by Mechanical Unloading by Lloyd, Shane A, Lang, Charles H, Zhang, Yue, Paul, Emmanuel M, Laufenberg, Lacee J, Lewis, Gregory S, Donahue, Henry J

“…ABSTRACT Mechanical unloading induces muscle atrophy and bone loss; however, the time course and interdependence of these effects is not well defined. We…”
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Regulation of muscle protein synthesis during sepsis and inflammation by Lang, Charles H, Frost, Robert A, Vary, Thomas C

“…Prolonged sepsis and exposure to an inflammatory milieu decreases muscle protein synthesis and reduces muscle mass. As a result of its ability to integrate…”
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