Search Results - "Lane, Karen A"

Predicting synthetic lethal interactions using conserved patterns in protein interaction networks by Benstead-Hume, Graeme, Chen, Xiangrong, Hopkins, Suzanna R, Lane, Karen A, Downs, Jessica A, Pearl, Frances M G

“…In response to a need for improved treatments, a number of promising novel targeted cancer therapies are being developed that exploit human synthetic lethal…”
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The role of the SWI/SNF chromatin remodelling complex in the response to DNA double strand breaks by Harrod, Alison, Lane, Karen A., Downs, Jessica A.

“…Mammalian cells possess multiple closely related SWI/SNF chromatin remodelling complexes. These complexes have been implicated in the cellular response to DNA…”
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PBAF loss leads to DNA damage-induced inflammatory signaling through defective G2/M checkpoint maintenance by Feng, Hugang, Lane, Karen A, Roumeliotis, Theodoros I, Jeggo, Penny A, Somaiah, Navita, Choudhary, Jyoti S, Downs, Jessica A

“…The PBRM1 subunit of the PBAF (SWI/SNF) chromatin remodeling complex is mutated in ∼40% of clear cell renal cancers. PBRM1 loss has been implicated in…”
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