Search Results - "Lane, Emma L."

Defining the unknowns for cell therapies in Parkinson's disease by Lane, Emma L, Lelos, Mariah J

“…First-in-human clinical trials have commenced to test the safety and efficacy of cell therapies for people with Parkinson's disease (PD). Proof of concept that…”
Get full text

L-dopa-Dependent Effects of GLP-1R Agonists on the Survival of Dopaminergic Cells Transplanted into a Rat Model of Parkinson Disease by Elabi, Osama F, Davies, Jeffrey S, Lane, Emma L

“…Cell therapy is a promising treatment for Parkinson's disease (PD), however clinical trials to date have shown relatively low survival and significant…”
Get full text

Impaired cognitive and motor function are coincident with l-DOPA-induced dyskinesia in a model of Parkinson’s disease by Lelos, Mariah J., Murphy, Ellen M., Lindgren, Hanna S., Dunnett, Stephen B., Lane, Emma L.

“…Dopamine transmission has been implicated in motor and cognitive function. In Parkinson’s disease (PD), dopamine replacement using the precursor drug l -DOPA…”
Get full text

Unilateral nigrostriatal 6-hydroxydopamine lesions in mice I: Motor impairments identify extent of dopamine depletion at three different lesion sites by Heuer, Andreas, Smith, Gaynor A., Lelos, Mariah J., Lane, Emma L., Dunnett, Stephen B.

“…► A full characterisation of 6-OHDA lesion mouse models with a screen of behavioural hand tests. ► Mice lesioned to the striatum, MFB and SN have different…”
Get full text

Comparison of rating scales used to evaluate l -DOPA-induced dyskinesia in the 6-OHDA lesioned rat by Breger, Ludivine S, Dunnett, Stephen B, Lane, Emma L

“…Abstract Abnormal involuntary movement (AIM) rating scales are frequently used to study the mechanisms underlying l -DOPA-induced dyskinesia (LID) in 6-OHDA…”
Get full text

L‐DOPA for Parkinson's disease—a bittersweet pill by Lane, Emma L.

“…3,4‐dihydroxy‐L‐phenylalanine (L‐DOPA) is the gold standard treatment for Parkinson's disease. It has earned that title through its highly effective treatment…”
Get full text

Factors affecting the choice of first-line therapy in Parkinson’s disease patients in Wales: A population-based study by Orayj, Khalid, Akbari, Ashley, Lacey, Arron, Smith, Mathew, Pickrell, Owen, Lane, Emma L.

“…First line treatment for Parkinson’s disease (PD) is typically either L-dopa or a non-ergot dopamine agonist (DA). However, the options for the treatment of…”
Get full text

Dopaminergic Progenitors Derived From Epiblast Stem Cells Function Similarly to Primary VM-Derived Progenitors When Transplanted Into a Parkinson's Disease Model by Precious, Sophie V, Smith, Gaynor A, Heuer, Andreas, Jaeger, Ines, Lane, Emma L, Dunnett, Stephen B, Li, Meng, Kelly, Claire M, Rosser, Anne E

“…Neural transplantation in neurodegenerative diseases such as Parkinson's disease (PD) offers to replace cells lost during the progression of the disease…”
Get full text

Pharmacological modulation of amphetamine-induced dyskinesia in transplanted hemi-parkinsonian rats by Smith, Gaynor A., Breger, Ludivine S., Lane, Emma L., Dunnett, Stephen B.

“…Foetal cell transplantation in patients with Parkinson’s disease can induce motor complications independent of l-DOPA administration, known as graft-induced…”
Get full text

Brain repair in a unilateral rat model of Huntington's disease: new insights into impairment and restoration of forelimb movement patterns by Klein, Alexander, Lane, Emma L, Dunnett, Stephen B

“…Huntington's disease (HD) produces severe neurodegeneration in the striatum leading to disabling motor impairments, including the loss of control of skilled…”
Get full text

Inhibition of 7α,26-dihydroxycholesterol biosynthesis promotes midbrain dopaminergic neuron development by Hennegan, James, Bryant, Aled H., Griffiths, Lauren, Trigano, Matthieu, Bartley, Oliver J.M., Bartlett, Joanna J., Minahan, Carys, Abreu de Oliveira, Willy Antoni, Yutuc, Eylan, Ntikas, Sotirios, Bartsocas, Christos S., Markouri, Margarita, Antoniadou, Eleni, Laina, Ioanna, Howell, Owain W., Li, Meng, Wang, Yuqin, Griffiths, William J., Lane, Emma L., Lelos, Mariah J., Theofilopoulos, Spyridon

“…Dysregulated cholesterol metabolism has been linked to neurodegeneration. We previously found that free, non-esterified, 7α,(25R)26-dihydroxycholesterol…”
Get full text

Spontaneous Graft‐Induced Dyskinesias Are Independent of 5‐HT Neurons and Levodopa Priming in a Model of Parkinson's Disease by Lane, Emma L., Harrison, David J., Ramos‐Varas, Elena, Hills, Rachel, Turner, Sophie, Lelos, Mariah J.

“…ABSTRACT Background The risk of graft‐induced dyskinesias (GIDs) presents a major challenge in progressing cell transplantation as a therapy for Parkinson's…”
Get full text

PINK1-Dependent Mitophagy Inhibits Elevated Ubiquitin Phosphorylation Caused by Mitochondrial Damage by Lambourne, Olivia A., Bell, Shane, Wilhelm, Léa P., Yarbrough, Erika B., Holly, Gabriel G., Russell, Oliver M., Alghamdi, Arwa M., Fdel, Azeza M., Varricchio, Carmine, Lane, Emma L., Ganley, Ian G., Jones, Arwyn T., Goldberg, Matthew S., Mehellou, Youcef

“…Ubiquitin phosphorylation by the mitochondrial protein kinase PTEN-induced kinase 1 (PINK1), upon mitochondrial depolarization, is an important intermediate…”
Get full text

Influence of chronic L-DOPA treatment on immune response following allogeneic and xenogeneic graft in a rat model of Parkinson’s disease by Breger, Ludivine S, Kienle, Korbinian, Smith, Gaynor A, Dunnett, Stephen B, Lane, Emma L

“…Abstract Although intrastriatal transplantation of fetal cells for the treatment of Parkinson’s disease had shown encouraging results in initial open-label…”
Get full text

Unilateral nigrostriatal 6-hydroxydopamine lesions in mice II: Predicting l-DOPA-induced dyskinesia by Smith, Gaynor A., Heuer, Andreas, Dunnett, Stephen B., Lane, Emma L.

“…► Behavioural characterisation of l-DOPA induced dyskinesia in 6-OHDA lesion mouse models. ► l-DOPA induced dyskinesia had distinct profiles in striatal, MFB…”
Get full text

Neural grafting in Parkinson's disease unraveling the mechanisms underlying graft-induced dyskinesia by Lane, Emma L, Björklund, Anders, Dunnett, Stephen B, Winkler, Christian

“…The development of neural transplantation as a treatment for Parkinson's disease has been compromised by a lack of functional efficacy and the appearance of…”
Get more information

Potential cellular and regenerative approaches for the treatment of Parkinson's disease by Lane, Emma L, Handley, Olivia J, Rosser, Anne E, Dunnett, Stephen B

“…Parkinson's disease is most commonly treated with a range of pharmacotherapeutics, with the more recent introduction of surgical techniques including…”
Get full text

L-DOPA- and graft-induced dyskinesia following transplantation by Lane, Emma L, Winkler, Christian

“…Recent clinical and preclinical data are shedding greater light on the nuances of transplantation of fetal tissue for the treatment of Parkinson's disease. The…”
Get more information

Human stem cells for CNS repair by Zietlow, Rike, Lane, Emma L., Dunnett, Stephen B., Rosser, Anne E.

“…Although most peripheral tissues have at least a limited ability for self-repair, the central nervous system (CNS) has long been known to be relatively…”
Get full text

Clinical and experimental experiences of graft-induced dyskinesia by Lane, Emma L

“…Clinical trials evaluating transplantation of fetal tissue for the treatment of Parkinson's disease identified the unexpected side effect of abnormal movements…”
Get more information