Search Results - "Lane, E.L"

The Impact of Ghrelin on the Survival and Efficacy of Dopaminergic Fetal Grafts in the 6-OHDA-Lesioned Rat by Elabi, O.F., Duskova, K., Davies, J.S., Lane, E.L.

“…•GHSR1a was detected on E14 ventral mesencephalic cells.•Expression persists in an intrastriatal graft into 6-OHDA rats.•Ghrelin and JMV-2894 had no effect on…”
Get full text

Neuroinflammation in the generation of post-transplantation dyskinesia in Parkinson's disease by Lane, E.L, Soulet, D, Vercammen, L, Cenci, M.A, Brundin, P

“…Abstract The observation that neural grafts can induce dyskinesias has severely hindered the development of a transplantation therapy for Parkinson's disease…”
Get full text

Context-driven changes in l -DOPA-induced behaviours in the 6-OHDA lesioned rat by Lane, E.L, Daly, C.S, Smith, G.A, Dunnett, S.B

“…Abstract Both contralateral rotational behaviour and dyskinetic abnormal involuntary movements (AIMs) are induced by the administration of l -DOPA in the…”
Get full text

The impact of graft size on the development of dyskinesia following intrastriatal grafting of embryonic dopamine neurons in the rat by Lane, E.L., Winkler, C., Brundin, P., Cenci, M.A.

“…Intrastriatal transplants of embryonic ventral mesencephalon can cause dyskinesia in patients with Parkinson's disease (PD). We assessed the impact of…”
Get full text

Increased efficacy of the 6-hydroxydopamine lesion of the median forebrain bundle in small rats, by modification of the stereotaxic coordinates by Torres, E.M., Lane, E.L., Heuer, A., Smith, G.A., Murphy, E., Dunnett, S.B.

“…► Decreasing efficacy of the 6-hydroxydopamine MFB lesion is documented. ► Commercial pressures on suppliers and researchers mean rats are smaller. ►…”
Get full text

Priming for L-DOPA-induced abnormal involuntary movements increases the severity of amphetamine-induced dyskinesia in grafted rats by Lane, E.L., Vercammen, L., Cenci, M.A., Brundin, P.

“…In some patients, graft-induced dyskinesia develops following intrastriatal transplantation of embryonic neural tissue for the treatment of Parkinson's…”
Get full text

Does contraversive circling in the 6-OHDA-lesioned rat indicate an ability to induce motor complications as well as therapeutic effects in Parkinson's disease? by Lane, E.L., Cheetham, S.C., Jenner, P.

“…Circling behaviour in unilateral 6-OHDA-lesioned rats is interpreted as being opposite in direction to the side of the brain with highest striatal dopaminergic…”
Get full text