Search Results - "Lane, Denis"

Prognostic significance of IL-6 and IL-8 ascites levels in ovarian cancer patients by Lane, Denis, Matte, Isabelle, Rancourt, Claudine, Piché, Alain

“…The acellular fraction of epithelial ovarian cancer (EOC) ascites promotes de novo resistance of tumor cells and thus supports the idea that tumor cells may…”
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Ovarian cancer ascites increase Mcl-1 expression in tumor cells through ERK1/2-Elk-1 signaling to attenuate TRAIL-induced apoptosis by Goncharenko-Khaider, Nadzeya, Matte, Isabelle, Lane, Denis, Rancourt, Claudine, Piché, Alain

“…Ascites may affect the progression of ovarian cancer (OC). In particular, soluble factors present in OC ascites can create a protective environment for tumor…”
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Malignant ascites protect against TRAIL‐induced apoptosis by activating the PI3K/Akt pathway in human ovarian carcinoma cells by Lane, Denis, Robert, Véronique, Grondin, Roxanne, Rancourt, Claudine, Piché, Alain

“…Ascites are commonly found in ovarian cancer patients with advanced disease and are rich in cellular components and growth‐promoting factors. The purpose of…”
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Osteoprotegerin (OPG) protects ovarian cancer cells from TRAIL-induced apoptosis but does not contribute to malignant ascites-mediated attenuation of TRAIL-induced apoptosis by Lane, Denis, Matte, Isabelle, Rancourt, Claudine, Piché, Alain

“…Resistance to apoptosis is a major problem in ovarian cancer and correlates with poor prognosis. Osteoprotegerin (OPG) is a secreted factor in malignant…”
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Antiapoptotic Proteins Bcl-2 and Bcl-XL Inhibit Clostridium difficile Toxin A-Induced Cell Death in Human Epithelial Cells by Matte, Isabelle, Lane, Denis, Côté, Élodie, Asselin, Ann-Élise, Fortier, Louis-Charles, Asselin, Claude, Piché, Alain

“…It has been well established that Clostridium difficile toxin A (TcdA) induces cell death in human epithelial cells. However, the mechanism of TcdA-induced…”
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The prosurvival activity of ascites against TRAIL is associated with a shorter disease-free interval in patients with ovarian cancer by Lane, Denis, Matte, Isabelle, Rancourt, Claudine, Piché, Alain

“…The production of ascites is a common complication of ovarian cancer. Ascites constitute a unique tumor microenvironment that may affect disease progression…”
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Acquired resistance to TRAIL-induced apoptosis in human ovarian cancer cells is conferred by increased turnover of mature caspase-3 by Denis Lane, Marceline Côté, Roxanne Grondin, Marie-Christine Couture, Alain Piché

“…Little is known on how cancer cells can acquire resistance to tumor necrosis factor–related apoptosis-inducing ligand (TRAIL). In this study, we established…”
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CA125 (MUC16) tumor antigen selectively modulates the sensitivity of ovarian cancer cells to genotoxic drug-induced apoptosis by Boivin, Marianne, Lane, Denis, Piché, Alain, Rancourt, Claudine

“…Abstract Objective Little is known about the biological functions of CA125/MUC16 tumor antigen. Here, we examined the role of CA125/MUC16 in regulating the…”
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Inflammation-regulating factors in ascites as predictive biomarkers of drug resistance and progression-free survival in serous epithelial ovarian cancers by Lane, Denis, Matte, Isabelle, Garde-Granger, Perrine, Laplante, Claude, Carignan, Alex, Rancourt, Claudine, Piché, Alain

“…Platinum-based combination therapy is the standard first-line treatment for women with advanced serous epithelial ovarian carcinoma (EOC). However, about 20 %…”
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CCL18 from ascites promotes ovarian cancer cell migration through proline-rich tyrosine kinase 2 signaling by Lane, Denis, Matte, Isabelle, Laplante, Claude, Garde-Granger, Perrine, Carignan, Alex, Bessette, Paul, Rancourt, Claudine, Piché, Alain

“…Ovarian cancer (OC) ascites consist in a proinflammatory tumor environment that is characterized by the presence of various cytokines, chemokines and growth…”
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Ovarian cancer ascites enhance the migration of patient‐derived peritoneal mesothelial cells via cMet pathway through HGF‐dependent and ‐independent mechanisms by Matte, Isabelle, Lane, Denis, Laplante, Claude, Garde‐Granger, Perrine, Rancourt, Claudine, Piché, Alain

“…Ovarian cancer ascites consist of a proinflammatory environment that is characterized by the presence of abundant human peritoneal mesothelial cells (HPMCs)…”
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Profiling of cytokines in human epithelial ovarian cancer ascites by Matte, Isabelle, Lane, Denis, Laplante, Claude, Rancourt, Claudine, Piché, Alain

“…The behavior of tumor cells is influenced by the composition of the surrounding tumor environment. The importance of ascites in ovarian cancer (OC) progression…”
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Ascites IL-10 Promotes Ovarian Cancer Cell Migration by Lane, Denis, Matte, Isabelle, Garde-Granger, Perrine, Bessette, Paul, Piché, Alain

“…Ovarian cancer (OC) ascites is an inflammatory and immunosuppressive tumor environment characterized by the presence of various cytokines, chemokines and…”
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Role of malignant ascites on human mesothelial cells and their gene expression profiles by Matte, Isabelle, Lane, Denis, Bachvarov, Dimcho, Rancourt, Claudine, Piché, Alain

“…Malignant ascites is often present at diagnostic in women with advanced ovarian cancer (OC) and its presence is associated with a worse outcome. Human…”
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MUC16 mucin (CA125) attenuates TRAIL-induced apoptosis by decreasing TRAIL receptor R2 expression and increasing c-FLIP expression by Matte, Isabelle, Lane, Denis, Boivin, Marianne, Rancourt, Claudine, Piché, Alain

“…MUC16 (CA125) is a large transmembrane mucin protein (> 200 kDa) aberrantly expressed in approximately 80% of human epithelial ovarian cancers (EOC). MUC16…”
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Osteoprotegerin (OPG) activates integrin, focal adhesion kinase (FAK), and Akt signaling in ovarian cancer cells to attenuate TRAIL-induced apoptosis by Lane, Denis, Matte, Isabelle, Laplante, Claude, Garde-Granger, Perrine, Rancourt, Claudine, Piché, Alain

“…Resistance to apoptosis is a major problem in ovarian cancer (OC) and correlates with poor prognosis. Osteoprotegerin (OPG) is a soluble secreted factor that…”
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Targeted ovarian cancer treatment: the TRAILs of resistance by Khaider, Nadzeya Goncharenko, Lane, Denis, Matte, Isabelle, Rancourt, Claudine, Piché, Alain

“…Ovarian cancer (OC) is the leading cause of death from gynecological malignancies. Although most patients respond to the initial therapy when presenting with…”
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Antiapoptotic Proteins Bcl-2 and Bcl-X L Inhibit Clostridium difficile Toxin A-Induced Cell Death in Human Epithelial Cells by Matte, Isabelle, Lane, Denis, Côté, Élodie, Asselin, Ann-Élise, Fortier, Louis-Charles, Asselin, Claude, Piché, Alain

“…It has been well established that Clostridium difficile toxin A (TcdA) induces cell death in human epithelial cells. However, the mechanism of TcdA-induced…”
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Osteoprotegerin , and Akt signaling in ovarian cancer cells to attenuate TRAIL-induced apoptosis by Lane, Denis, Matte, Isabelle, Laplante, Claude, Garde-Granger, Perrine, Rancourt, Claudine, Pichñ, Alain

“…Background Resistance to apoptosis is a major problem in ovarian cancer (OC) and correlates with poor prognosis. Osteoprotegerin (OPG) is a soluble secreted…”
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Differential induction of apoptosis by tumor necrosis factor-related apoptosis-inducing ligand in human ovarian carcinoma cells by Lane, Denis, Cartier, Andréanne, L'Espérance, Sylvain, Côté, Marceline, Rancourt, Claudine, Piché, Alain

“…Objectives. In this study, we examine the sensitivity of a panel of ovarian carcinoma cells, which includes four primary ovarian cancer cell samples, and four…”
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