Search Results - "Lane, B C"

Nonsteroidal Selective Glucocorticoid Modulators:  the Effect of C-5 Alkyl Substitution on the Transcriptional Activation/Repression Profile of 2,5-Dihydro-10-methoxy-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines by Elmore, Steven W, Coghlan, Michael J, Anderson, David D, Pratt, John K, Green, Brian E, Wang, Alan X, Stashko, Michael A, Lin, Chun W, Tyree, Curtis M, Miner, Jeffery N, Jacobson, Peer B, Wilcox, Denise M, Lane, Benjamin C

“…The preparation and characterization of a series of selective glucocorticoid receptor modulators are described. The preliminary structure−activity relationship…”
Get full text

Synthesis and Characterization of Non-Steroidal Ligands for the Glucocorticoid Receptor:  Selective Quinoline Derivatives with Prednisolone-Equivalent Functional Activity by Coghlan, Michael J, Kym, Philip R, Elmore, Steven W, Wang, Alan X, Luly, Jay R, Wilcox, Denise, Stashko, Michael, Lin, Chun-Wei, Miner, Jeffrey, Tyree, Curtis, Nakane, Masaki, Jacobson, Peer, Lane, Benjamin C

“…A novel class of functional ligands for the human glucocorticoid receptor is described. Substituents in the C-10 position of the tetracyclic core are essential…”
Get full text

Chemoattractant receptor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate in human polymorphonuclear leukocyte membranes. Requirement for a guanine nucleotide regulatory protein by Smith, C D, Lane, B C, Kusaka, I, Verghese, M W, Snyderman, R

“…Incubation of plasma membranes from human polymorphonuclear leukocytes (PMNs) with [gamma-32P]ATP in the presence of MgCl2 resulted in the formation of…”
Get full text

32-Ascomycinyloxyacetic Acid Derived Immunosuppressants. Independence of Immunophilin Binding and Immunosuppressive Potency by Wagner, Rolf, Rhoades, Teresa A, Or, Yat Sun, Lane, Benjamin C, Hsieh, Gin, Mollison, Karl W, Luly, Jay R

“…The potent immunosuppressant ascomycin (1b) was selectively alkylated at the C-32 carbinol, thus providing esters and amides of 32-ascomycinyloxyacetic acid…”
Get full text

A Macrolactam Inhibitor of T Helper Type 1 and T Helper Type 2 Cytokine Biosynthesis for Topical Treatment of Inflammatory Skin Diseases by MOLLISON, K. W, FEY, T. A, CANNON, J, MARSH, K, CARTER, G. W, OR, Y.-S, CHEN, Y.-W, HSIEH, G. C, LULY, J. R, GAUVIN, D. M, KOLANO, R. M, SHEETS, M. P, SMITH, M. L, PONG, M, NIKOLAIDIS, N. M, LANE, B. C, TREVILLYAN, J. M

“…T lymphocytes play a critical part in inflammatory skin diseases but are targeted by available therapies that have only partial efficacy, significant…”
Get full text

Retention of Immunosuppressant Activity in an Ascomycin Analogue Lacking a Hydrogen-Bonding Interaction with FKBP12 by Wiedeman, Paul E, Fesik, Stephen W, Petros, Andrew M, Nettesheim, David G, Mollison, Karl W, Lane, Benjamin C, Or, Yat Sun, Luly, Jay R

“…C24-Deoxyascomycin was prepared in a two-step process from ascomycin and evaluated for its immunosuppressant activity relative to ascomycin and FK506. An…”
Get full text

Induction of selective biological responses to chemoattractants in a human monocyte-like cell line by KAY, G. E, LANE, B. C, SNYDERMAN, R

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Studies on an immunosuppressive macrolactam, ascomycin: Synthesis of a C-33 hydroxyl derivative by Kawai, Megumi, Gunawardana, Indrani W.K., Mollison, Karl W., Hsieh, Gin C., Lane, Benjamin C., Luly, Jay R.

“…Ascomycin 2, a close analogue of the immunosuppressant FK506 1, was modified to incorporate a hydroxyl group at the C-33 position. This increased the aqueous…”
Get full text

Discovery of FK 506 analogues that are nontoxic to mouse pancreatic beta cells in vitro but show diabetogenic potential when administered to the rat by Mollison, K W, Andrews, J M, Fey, T A, Miller, L N, Krause, R A, Bretheim, P T, Brandt, J A, Wagner, R, Lane, B C, Hsieh, G C, Luly, J R

Get more information

High-level synthesis of the 12-kDa human FK506-binding protein in Escherichia coli using translational coupling by Pilot-Matias, T J, Pratt, S D, Lane, B C

“…The gene encoding the 12-kDa cytosolic form of human FK506-binding protein (hFKBP-12) was isolated from a Jurkat T-cell cDNA library and expressed in three…”
Get more information

Evaluation of calcineurin's role in the immunosuppressive activity of FK 506, related macrolactams, and cyclosporine by Lane, B C, Miller, L N, Kawai, M, Or, Y S, Wiedeman, P, Holzman, T F, Luly, J R

Get more information

Fc receptors of mouse cell lines. I. Distinct proteins mediate the IgG subclass-specific Fc binding activities of macrophages by Lane, BC, Cooper, SM

“…To determine the biochemical basis for the two distinct IgG subclass binding specificities on mouse macrophage-like cell lines, Fc-binding proteins were…”
Get full text

Characterization of the cell wall and cell wall proteins of Chromatium vinosum by Lane, B C, Hurlbert, R E

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Isolation and partial characterization of the major outer membrane protein of Chromatium vinosum by Lane, B C, Hurlbert, R E

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Spoilage of hydrogel contact lenses by lipid deposits. Tear-film potassium depression, fat, protein, and alcohol consumption by Hart, D E, Lane, B C, Josephson, J E, Tisdale, R R, Gzik, M, Leahy, R, Dennis, R

“…"Jelly-bump" deposits, which are composed mainly of lipids, on high water content, extended-wear hydrogel lenses, are a clinically significant problem of…”
Get more information

Two schools of desire : Nature and marriage in seventeenth-century Puritanism : Biblical interpretation and the construction of Christian sexualities by LANE, B. C

Get full text

Structural evidence for distinct IgG subclass-specific Fc receptors on mouse peritoneal macrophages by Lane, B C, Kan-Mitchell, J, Mitchell, M S, Cooper, S M

“…Membrane proteins which selectively bind to the Fc portion of IgG were identified in the Nonidet P-40 extracts of radiolabeled thioglycollate- elicited mouse…”
Get full text

Fc receptors of mouse cell lines. II: IgG binding specificity and identification of the Fc receptor on a lymphoid leukemia by LANE, B. C, BRICKER, M. D, COOPER, S. M

“…The authors determined the binding specificity of the Fc receptors on the murine lymphoid leukemia, L1210, which bears several surface antigens characteristic…”
Get full text

Cytolysis of actinomycin D-treated target cells by cell-free supernatants from human monocytes by McKinnon, K P, Chen, A R, Argov, S, Lane, B C, Koren, H S

“…The lytic mechanism of human peripheral blood monocytes was studied by using as targets actinomycin D-treated WEHI-164, an NK-insensitive murine fibrosarcoma…”
Get more information

Structure-activity profiles of macrolactam immunosuppressant FK-506 analogues by Kawai, Megumi, Lane, Benjamin C., Hsieh, Gin C., Mollison, Karl W., Carter, George W., Luly, Jay R.

“…The immunosuppressive agent FK-506 has received much attention due to its efficacy and potency in the areas of transplant rejection and autoimmune disease…”
Get full text